Managing Side Effects of HER2 Targeted Therapy - Zanidatamab & Trastuzumab deruxtecan (T-DXd)

This is an I Heart Podcast. Guaranteed Human. There was no anything inside those eyes. They turned black. It scared the hell out of me. Evil wake up and the one that saw the murder take place by Kriveth Indepipo. Anthony Depipo showed no signs of remorse appearing unfazed after being sentenced to the maximum. I said I'm not guilty, I'll take it to the grave. Listen to the devil's quarry in the bone valley feed on the I Heart Radio app or podcast or wherever you get your podcasts. If you're seeking to try to understand the forensic science behind these cases that we hear about in the news, body bags is where you need to turn. There's no fluff. We do a deep dive into the forensics. Listen to body bags with Joseph Scott Morgan on America's number one podcast network. I Heart. Open your free I Heart app and search body bags with Joseph Scott Morgan and start listening. Every family has its secrets. But what happens when you discover that your dad has been living a double life. That is not the look of an innocent man. Is everyone lying to me about who they are? I felt such desperation. I felt it was what I had to do. Listen to Deep Cover, The Family Man. I'm the I Heart Radio app, Apple podcasts, or wherever you get your podcasts. I've been hearing for decades that the markets can solve climate change. Today we have more incentives for market solutions than ever and emissions are rising. On this season of drilled, carbon cowboys, the story of three market solutions colliding in one multinational boom-dougal. You got to get a crucial, the guy is pregnant. They're Republicans. They don't give a f***ing amount of news. Listen on the I Heart Radio app, Apple podcasts, or wherever you get your podcasts. [Music] Amy Robock and TJ Holmes present Killer Thriller with your host, Alisa Donovan. Hey everyone, it's Alisa Donovan, host of Killer Thriller. And I am here with my friend Jen Fessler from Killer Thriller. Docu. Hi my friend. Hi, love you. So, while most people are celebrating with backyard barbecues, beach days and fireworks, we are doing what we do best, which is diving into some unbelievable true crime stories connected to America's birthday. Fun. From shocking murders to mysteries tied to the 4th of July celebrations, these cases prove that sometimes the most explosive events of the holiday aren't happening in the sky. So, whether you're heading to a barbecue, sitting in traffic on a holiday road trip, or waiting for the fireworks to begin, settle in as we explore the darker side of the 4th of July. Now, before we get into these cases, Jen, what's your favorite 4th of July tradition? I mean, I don't really have 4th of July traditions per se. Like, when I was young, I was always at sleep-way camp. And so, that was really fun. Yes. It was to be with friends and fireworks and burgers and hot dogs. And my daughter's there right now. Oh, she is. Okay. That's another discussion. Now, I want to know where she is. Okay. Anyway. So, yeah. So, that was always where I was for, you know, the 4th of July. As I got older with my kids, they were at camp for a lot of that, unless they were babies. But there have been, obviously, there's always a parade. There's four couples we got together for a few years. A couple of friends every 4th of July, that was fun. Barbecue, you know, burgers and hot dogs and all of that. But I don't have necessarily traditions to you. Well, no, this kind of leads me into my next question for you, which is going to be, has anything ever gone wrong at the 4th of July? Yeah. And I'd like to share how my least favorite tradition, which couples with something going terribly awry, is that. I broke my radius and all the bones, doing backhand springs on wet grass and emerald bay after a day of light drinking. Really? So. Don't do something like this when you were a ch- Well, I guess not when you were a ch- No, I was 30. And I was also wearing flip flops. And I wanted to impress my then boyfriend by telling him, "Did you know I could do backhand springs?" And he was like, "What?" This is a nightmare, embarrassing, horrible, painful. Yeah, it was sort of the beginning of the end of our relationship. It went on another year, but I loved him dearly anyway. Yeah, so I said, "Yeah, I could do backhand springs." And he was like, "What?" And so he puts the flashlight, I'm wearing flip flops, and I started, I did a round off, and then I stopped short, and I was like, "Oh, this doesn't feel right." And he said, "Don't be scared. You can do it." And I. So I was like, "You're right." And I went to do it, and I went up so high instead of going backwards, because I had forgotten, because I haven't done it in length 20 years. And boy, that crack was heard round the world, and then my screams all the way down the one trying to get to Newport emergency room. So anyway. That's my fourth of July. My story is from last year, more recently, where we, bunch of friends, came, we have a place at the beach, and we probably had 15 people or something, and we went to the beach to watch the fireworks, and we might have been smoking a little something, we might have been drinking a little something, and maybe, maybe, maybe, maybe, allegedly. And we drove bikes there, got back on the bike. Now, I'm not a bike rider, as it turns out, there's a whole bunch of stories. It's different than that at the point. Different. I shouldn't have been at that point. And got on the bike didn't even begin to pedal when I fell completely down, and blood everywhere. And all my friends were laughing so hard that it was a stranger, actually, that came to me and helped me get up. Blood everywhere, bruises everywhere. Well, this is why you and I are doing this instead of celebrating the fourth of July. That's why we're like staying, and we're going to have these conversations. It's not our favorite holiday. Right. It is not the favorite holiday for many of people that we're about to discuss. Exactly. It's not our favorite holiday at all. That's right. So, yeah, should we start with Marilyn Shepard? Yes. So, this is one of the most infamous American murder cases. 31-year-old Marilyn Shepard, who was four months pregnant, was brutally bludgeoned to death in her Bay Village, Ohio home, in the early hours of the fourth of July. Her husband, Dr. Shepard, claimed he was asleep downstairs. When he heard his wife's screams and encountered a "bushy-haired intruder" inside their home. So, this quickly became a national media sensation, and all the newspapers were implying very heavily that Sam was guilty long before his trial, and he was convicted in 1954. But years later, the US Supreme Court overturned the conviction ruling that media coverage had made a fair trial impossible. And then he was later acquitted in 1966. So, this is the case that went on to inspire the story behind the fugitive. The only thing I think is when you hear those dates, right? Like, what would it have been like now? Who knows, right? Exactly. Right. It's hard to know. So, what does all of this mean? Was Sam Shepard guilty? And would he get a fair trial? I think about so many people that once the media has made a decision, and they have kind of told the public that today, it's like, you can't recover because it's all encompassing. It's just everywhere. And then, I don't know, would you think that he would? Would he get a more fair trial today? Yeah. I mean, I don't know, more fair or less fair, right? More information. Right. Maybe DNA. Things that really can determine proof. And still, the guy still went to prison for 20 years. Yeah. So, if he didn't do it, it's not like that becomes erased. Right. Right. So, here's the case of Megan Barrasso. And so, from more park, California, this is back in 2001, and after spending the evening watching Fourth of July fireworks with friends, 20-year-old college student, Megan Barrasso was driving home and she became the victim of a violent attack. Investigators later determined she was pursued in shot from another vehicle in what appeared to be a completely random act of holiday violence. Her abandoned car was found the following day, shocking the Ventura County community and the senseless nature of the crime combined with its timing after a holiday celebration made the case especially haunting. You know, I think about New Year's Eve, and I absolutely hate the holiday and don't want to be out. And I think crazy things happen on New Year's Eve because everyone's wasted. Right. And everybody has this feeling like I have to have a good time. That's exactly right. Like this pressure of you need to tell a story about it later and have kind of the most intense joy ever or something. Yeah. That's really, that's actually a great way of putting it. Yes. That is how it feels. There's a pressure to have the best time ever. And I randomly, well, Kirli, you and I don't on the Fourth of July. But even like a New Year's. But then for her to be so randomly shot. This is what's so scary to me is that it's literally it was a random act of violence. Which I wonder now is this was it gang related in somewhere like it's I don't know anything about more park I don't know how close that is to as soon as you hear that right like yeah like that you think was it was a gang related You know like one of those what is it called when someone has to and they're initiated and I have to kill someone Yeah, right, but it's I mean I don't need a lot to keep me up at night and make me afraid and Just thinking about that. I mean does it make you think like oh, maybe I shouldn't drive at night. Yeah Maybe I shouldn't drive it all right. I mean I don't drive at night because I can't see anymore. I can't really either But I still I do but but yeah, it's totally scary I get very afraid if I feel like somebody is driving a little too close or the fact following me, right? And you hear so many stories about you know specifically women but getting Carjacked and right that always freaks me out. I'm always looking for okay, so if what's the exit route right when I first moved to LA Now that you say that I remember that being my one of my biggest fears because coming from I move from New York City Where I never drove right and they would this was just like a whole other set of concerns right so then at night If you're at a red light and someone next to you I remember having this real fear of like oh my god. I gotta get home. Yep. Me too In the moment it felt like it was going on forever. I didn't think I was gonna live. I was terrified There was no Anything inside those eyes they turned black It scared the hell out of me That was your first murder case. Yes, yeah Fear to say this was the biggest case of your career. Yes, sir. Red but murder for sure. 12 year old child's balance it gets everything so People wake up and the woman saw the murder take place by Cree that in the pippo Anthony de Pippo showed no signs of remorse appearing unfazed after being sentenced to the maximum. I said I'm not guilty. I'll take it to the grief Listen to the devil's quarry on the I heart radio app Apple podcasts or wherever you get your podcasts and To hear the devil's quarry add free with exclusive content subscribe to love of for good plus on Apple podcasts If you're seeking to try to understand the forensic science behind these cases that we hear about in the news Body bags is where you need to turn there's no fluff. We do a deep dive into the forensics Listen to body bags with Joseph Scott Morgan on America's number one podcast network I heart open your free I heart app and search body bags with Joseph Scott Morgan and start listening Keith Jim Anko seemed like a mild mannered suburban dad But secretly he became someone else a master of disguise who went on a crime spree At the time did it seem like a crazy idea? It seemed very crazy But I felt so desperate that I felt it was The quickest easiest way out. Did you allow yourself to think about how we could go wrong and what that might look like? No, I didn't want to manifest that. I wonder I was trying to manifest success Every family has its secrets But what happens when you discover that your dad has been living a double life? That is not the look of an innocent This is going to change my life and my family dynamic forever because Everything that had existed prior in my reality is now untrue Listen to deep cover the family man. I mean I heart radio app Apple podcasts or wherever you get your podcasts A Decade ago the ethanol kingpin of Iowa became the king of corn in Brazil So we met with a lot of larger farmers went from Bahia to Tokyo teens to Montagro so he brought a team of executives They were gonna help the country get in on a gold rush carbon and its derivatives are gonna be really the next great Come on, he's gonna trade but back home in Iowa trouble was brewing If you live in Iowa your land your water and your voice could all be at risk thanks to a man named Bruce Rastetter now People are questioning if his climate solutions have anything to do with climate at all On this season of drilled carbon cowboys the story of how the ethanol kingpin of Iowa Became the king of corn in Brazil and what it tells us about the limits of technology and markets to solve the climate crisis Listen on the iHeart radio app Apple podcasts or wherever you get your podcasts All right, who do we have next we have next we have Irene Silverman and her disappearance This is an in New York City July of 1998 Irene was an 82 year old Socialite and a real estate owner and she disappeared from her upper east side townhouse shortly after a fourth of July gathering in 1998 and Authority soon focused on two tenants who had recently moved into her building and They turned out to be notorious con artists Kenneth Kymes Jr and Sante Kymes and investigators undercover this elaborate scheme involving identity theft financial fraud and These this alleged plan to take over Silverman's life and property So although her body was never recovered they were ultimately convicted based on overwhelming circumstantial evidence and They became the kind duo became one of the most infamous mother-son Criminal partnerships in American history. We're talking about a violent stranger with a gun and a car and shooting and then a manipulative con artist yes, who moves into your building. Yes, right? Which is more scary something random or something I know I mean who cares? They're both terrifying, but they're both terrifying. I think this idea of someone so Directly manipulating you especially an older person who has probably lived in the same environment for many years and feels very safe There and you know that is like a particular kind of Awfulness that is and that's just brutal. Yeah agreed agreed For listeners that don't know New York that well or like she lived they on the upper east side older Nice Very nice. Yeah, very nice neighborhood Probably I'm guessing the building itself was very nice lots of people with lots of money And you know, I don't know if you feel like this, but the planned out you know doing doing true crime The ones the most chilling for me are always the ones that were planned out Not just the random ones right now. They got into a fight and or you know somebody lost control It's more the calculation of it all yes Yes, I totally agree. I totally agree because that like the amount of time and energy and Use of your mind that it takes to actually methodically plan these things out is That is the is the creepiest and the worst Offends to me also I agree they freak me out All right, well here's another one the Coons family massacre. I had never heard of this and I am like wondering why I had never heard of this I haven't either, but it was it was 1987 so July 4th through the fifth throwing fourth of July celebrations in rural Wisconsin four members of the Coons Family were murdered at their farmhouse Creating one of the states most disturbing homicide cases the following morning authorities discovered the crime scene Which sparked a complex investigation involving questions of motives Evidence and ultimately long-running debate over whether the correct person was ultimately held responsible even years later This case continues to raise questions and divide opinion you know with with cases like this Don't you have to know? I mean that why I don't we don't I don't remember this story either and I Haven't seen it and they you know on a docu on a documentary, but Ultimately long-running debate over whether the correct person was ultimately held responsible how awful to not you know It's the right person in jail So I read some more on this case after I knew we might talk about it today and Apparently the guy who was arrested they couldn't prove that he murdered these people But they could prove that he kidnapped the one family member and then when he was in prison He was released after a certain amount of time and then went back and said I want to go back to prison What but but also said I was was not admitting his own guilt So I was like well, I wouldn't feel so unsettled after that I mean, oh wait he wasn't he just enjoyed prison. What do you mean? I don't I don't know so I think this speaks to maybe that What is it called when you have when you're in inmate and you've become sort of indoctrinated in that life? Yeah, I know what you're doing I know exactly, but you and I just they talk about it in the Shawshank redemption right right institutionalized kind of but there's a more specific So maybe it was that which also that's about a man wrongly accused of murdering his wife right My movie is one of my favorites my absolute one of my absolute favorites as well. Yeah, but I Love that movie. Sorry. I know I just washed it on a plane recently on one of my many We won't get into my travel miss haps as of late. That's for the leather The whole of the episodes the part where they're on the beach on the beach. Oh my god. Oh my god. Sorry guys If you haven't watched it you should watch it on 4th of july and maybe instead of going to big parties just Exactly just a home and watch some yes beautiful movies But I don't know you know what there are some communities that just never recover from from crimes and they're they talk about You know, I know they talk about it. Yes I'm forever, but I always feel badly hearing that there's so many people divided on whether or not somebody's innocent and that person is in jail and Because that right you never have closure. It's just constantly Torturing the surviving people we've talked a lot about things like that when they have been in small communities especially You know that it becomes a part of the fabric of the of the town in the community and the people and Not only those closest, but it becomes sort of known for that Yeah, like when you if something happens in a home And it's well known as harder to say I would think a lot. I don't want to buy a house where some gruesome murder happens Hate right right. They're all sorts of things that that are That happened as a result of this not just the actual Crimes, you know right I listen to have a great 4th of july well thanks you too you eat yourself a lot of hot dogs I'm gonna not break any bones nor am I going to Murder anyone my girl. Yeah, I plan on not breaking any bones bleeding. Hopefully I'd rather for not to bleed no blood no blood Early night in Shawshin redemption. Yeah situation same same. All right. Well, I love you. I love you This is super fun happy for all right honey talk soon. Okay. Bye. Bye You There was no Those eyes they turned black It scared the hell out of me Evil wake up and the woman saw the murder take place by creamette and the pippo Anthony de pippo showed no signs of remorse appearing unfazed after being sentenced to the maximum I said I'm not guilty I'll take it to the grave Listen to the devil's quarry in the bone valley feed on the iHark radio have apple podcasts or wherever you get your podcasts If you're seeking to try to understand the forensic science behind these cases that we hear about in the news Body bags is where you need to turn there's no fluff we do a deep dive into the forensics Listen to body bags with Joseph Scott Morgan on America's number one podcast network iHard Open your free iHard app and search body bags with Joseph Scott Morgan and start listening Every family has its secrets But what happens when you discover that your dad has been living a double life That is not the look of an innocent man Is everyone lying to me about who they are? I felt it was what I had to do Listen to deep cover the family man. I mean iHard radio app apple podcasts or wherever you get your podcasts I've been hearing for decades that the markets can solve climate change Today we have more incentives for market solutions than ever and emissions are rising On this season of drilled carbon cowboys the story of three market solutions colliding in one multinational boondoggle Listen on the iHard radio app apple podcasts or wherever you get your podcasts This is an iHard podcast guaranteed human