LDN | The Force Multiplier for Peptides and HRT

Hey everybody, this is Hunter Williams. I hope you're doing amazing wherever you might be in the world. Today's video is going to be all about low dose now. Trexon. This is something that I've made a video out about before and I've talked. I know pretty good length on different podcasts and different live streams and things I've done in the past. But today for 2026 and it's April 2026 right now. I wanted to do an updated video with LDN again, aka low dose now. Trexon. This is one of my favorite compounds out out there. Obviously, it's a pharmaceutical and it's been around for a long time. Now Trexon itself is actually a drug that is used to help people come off of opioids to help with opioid withdrawal. But when we use it at very low doses, it actually has a very different effect on the body and actually kind of works as like an immune system modulator. So it helps bring our immune system into balance, whether we have an overactive immune system, like an auto immune disease, where we have a very suppressed immune system. It kind of helps bring back into balance. And what I wanted to today is talk about specifically about what LDN can do just for the health benefits of it because even if it didn't relate to peptides and hormones and that stuff, I think there are many health benefits that we can get from LDN. But then also we're going to talk specifically about how it relates to our peptide use and our hormone units. And that's one thing I've not really heard anyone other than myself talk about. And I kind of want to help get this information out there because I think it's a very underutilized tool, especially when we look at all the chronic disease and all of these weird immune slash auto immune type diseases that we have out there because those are very relevant when we talk about the peptide conversation. So that's what we're going to cover today. As always, thank you guys so much for being here. I'm always overwhelmed with gratitude for the support that I get from you guys. So thank you for that. As always, just make sure you're there on the email list. Censorship again is out there right now. And so please make sure you're on the email list. There's always going to be a link to sign up wherever you're watching this video. Just to stay in touch with you again, I don't spam you guys. I just send out different studies or things that I'm reading about or also content that I am publishing and working on. So make sure you check that out and join the email list. And also too, if you want to be in my private group, make sure you have all of your questions answered. The best place to do that is inside the action collective, which is my private groups to check that out as well. We got over 200 people in there right now. And it's a really cool place to be with you. I've coaching calls every Thursday night at 8 PM Eastern. So not further do I'm going to share my screen and today we're going to talk about low dose and no trexone. All right, let's get into it today is going to be all about low dose now trexone. And actually the cool thing about this is even if you're getting it prescribed from a doctor, which there's a lot of really good anti aging telemed services out there. Now that we do that, it's only $1 per day in most cases. So pretty cheap. But why does LDN deserve a spot in our protocol? First of all, it has a 40 year safety record. So it's been around like I said for a really long time. We've never really seen any adverse events in any published clinical trial, especially on the low dose. And then there's obviously broad clinical benefits. So when we look at the benefits, we get autoimmune disease benefit, pain benefit benefits for the gut benefits for depression and mood disorders. We even see benefits in cancer. We also see benefits in PCOS for women, which side note, there's actually a big push right now to rename PCOS from a clinical perspective amongst practitioners to actually change it to re I think we're calling it female reproductive metabolic syndrome or something like that because it really is related to our metabolic health. And then we have obviously fertility, it being a benefit for fertility. Again, it's off Pat generic. You can usually get a 90 day supply for like somewhere between 30 and 80 bucks. That's about how much I pay for it. And again, when we talk about LDN, not only does it work really well for the things that we just talked about, but it also pairs really synergistically with HRT peptides and all of the things that we love to talk about in our world and actually can amplify the effects that we get from those. And so that's what we're going to look at today. To give you a little bit of background on it, there was this guy named Dr. Bernard Bahari, hopefully I'm pronouncing that right. But it was now trexone itself, so not the Lotus version, but now trexone itself was FDA approved in 1984 at 50 milligrams for opioid addiction. And it was a full 24 hour receptor blocker. However, 1985, this Harvard trainer, neurologist Dr. Bernard Bihari found that HIV and AIDS patients had less than 20% of normal endorphine levels. So what he does, he ran a dose ranging experiment from one milligram to four and a half milligrams of bedtime to see how they responded. And counterintuitively, he found that a tiny dose blocker suffers for only three to six hours instead of a full 24 hours. And the body compensates with around a 200 to 300% surgeon endorphins. And in Kaffalens, probably heard of this peptide called metin Kaffalens, which kind of acts like I don't know specifically because I haven't read enough on it. Basically acts as an anti-pain peptide. Then the drug clears and leaves the enhanced opioid signaling for around 18 to 20 hours. Basically to allow us to have a low inflammatory state in the body because we're getting the surge of endorphins. And so when we look at the results that he got from his trial around in the 1985 to 86 placebo HIV controlled trials around 50 patients, only 8% of them died. Whereas the ones that didn't receive it around 33% of them died. So it was a drastic difference. Again, a small trial, but we see a drastic difference in the amount of people that died that not have LDN, the ones that did have LDN. And since then, Bahari history, thousands of patients with autoimmune disease cancer and chronic pain before his death in 2010. And LDN remains entirely off label. It must be obtained from a compounding pharmacy. Most times, with a ballot prescription. Again, in most cases, you're not going to see this for sale. It doesn't come from a compounding pharmacy because it's a generic. It's so cheap. And the most common form is a capsule. You do see liquid sublingual or topical formulations, but I would recommend just the capsules to take. So let's look at the four mechanisms that LDN is actually working on to create these effects in the body. They're doing these simultaneously, but I think these are the four most important benefits that we get that it's going to confer. One is the endorphin rebound. So again, to go back to Dr. Bahari, what he was talking about, the bedtime dose triggers a common commonsentory surge in beta endorphin and met in caliphon. Again, you've probably heard of that peptide circulating around there on the wild called met in caliphon and receptor density and sensitivity also increase. Now, when the blockade wears off, more endorphins hit more sensitive receptors, enhancing pain modulation, mood and immune surveillance for the rest of the day. So again, we get this blockade of bedtime, a surge of endorphins and then a clearance of rebound, which again helps with immune surveillance and all of those things that we're talking about. The next mechanism is going to be the OGF and OGFR axis. So this goes back to 35 years of research, doctors Ian Zagon and Patricia McLaughlin at Penn State characterized his pathway. Again, OGF, which is met in caliphon, binds to OGFR on the outer nuclear envelope, triggering the upregulation of P16 and P21 cyclin-dependent kinase inhibitors, not to be confused with the peptide P20. This slows cell replication at the G1S checkpoint, which means that it's purely anti-prolifitive and not cytotoxic and LDN transonly blocks receptors, causing the body to produce more OGF and upregulate more OGFR. So this is the mechanism most relevant to cancer applications. But as you see in this diagram here, we take naltrexone or lodo naltrexone, it increases OGF, which is met in caliphon and then we get this cycle with P16 and P21 and then P16 and P21, lead to the things that would end up conferring anti-cancer effects from the LDN. We also have TL-TLR4 antagonism and this is where we see a lot of the immune benefits come in around lodo naltrexone. So in 2008, they discovered that naltrexone directly blocks total like receptor four on microglia and macrophages completely independent of opioid receptor activity. So even the isomort was zero, zero opioid activity blocks TL-LR4 and this oppresses microglial activation shifts microglia from pro-inflammatory M1 to anti-inflammatory M2 and reduces neuroinflammation via the TRAF, IRF3 pathway. So this is most relevant to chronic pain and neurological conditions. This is where we see those pain benefits come in and it gets that shifting from the M1 state to the M2 state. The naltrexone induces that really helps the body. And then when we look at the fourth mechanism, it's just basically going to be broad anti-inflammatory signaling. I would think and most people agree that anti-inflammatory things are going to be good for us obviously within a very specific context. Obviously you want the inflammatory cascade that comes after exercise because that helps with repair. But in 2017, Parkitney and Younger showed eight weeks of LDN significantly reduced 17 pro-inflammatory markers in fibromyalgia patients. So we have TH1 and TH2 rebalancing. Again, this goes into immune system. LDN will shift the immune response away from chronic inflammatory dominance, which a lot of people struggle with. I've struggled with that myself in the past. It also helps with regulatory T cells. So it increases T-regs, reducing autoimmune and inflammatory activity. And then we also have a normalization of the HPA axis. So it modulates the stress response towards normalized function, not chronic activation. And then this mechanism is this is what makes LDN really a force multiplier for everything else in the stack. And then also is going to layer on top of those peptides and hormones that we're taking to really get more of a benefit out of them. So we are to as LDN shine. Let's look at some of these use cases where we're really going to see a noted benefit. So all of these trials are small, but the direction of the effect is remarkably consistent. So benefit after benefit with essentially no downside. They were seeing and people using them. So let's look at autoimmune pain and gut. So there's been benefits shown and Hashimoto's MS, Crohn's, rheumatoid arthritis and lupus. So immune modulation without immune suppression around 40% of Hashimoto's patients. See meaningful improvement with significant antibody reductions, which is going to be Again, those thyroid antibodies being weighed up in Hashimoto's LDN is going to help bring those down. And again, you talk about that synergizing with a peptide like thymus and alpha-1, thymolin and L-37 could do really well. We see benefits in chronic pain in fibromyalgia. So a Stanford randomized controlled trial, 28.8% pain reduction versus 18% reduction from placebo. We also have a diabetic neuropathy RCT with similar efficacy to amatryptoline, but eight adverse events versus 52 from the amatryptoline. So for significant for significantly lower adverse events to the LDN than the neuropathy medication with similar efficacy, which is pretty cool. And again, not something I get asked about neuropathy all the time. What's the best peptide for neuropathy? Well, we have LDN. And again, it's going to work on top of some of these peptides who enhance the response. Then we look at gut health, Dr. Jill Smith and IH-funded RCT, 78% endoscopic response versus 28% placebo. So documented mucosal healing on endoscopy, not just symptom relief, which was pretty cool. When we look at Crohn's and again, that's one of the larger use cases. You see really good benefits of people experience with LDN. Now, let's look at a couple more depression. There was a Harvard RCT with an effect size of 1.45 and treatment resistant repression, which is a very large psychiatric effect when they use that scale measured in psychiatric disorders, cancer support. So the OGF and OGFR axis is present in 31 human cancer cell lines and LDN enhances chemotherapy efficacy while reducing side effects. So again, whether or not you believe in chemotherapy that comes up a lot in the conversation with peptides, I think a lot of peptides can help in relation to chemotherapy if you are doing chemotherapy. LDN is another one of those agents that works alongside it to kind of help some of the bad side effects that are coming from the chemotherapy. When we look at PCOS and fertility, menstrual cycles normalize an 80% of obese PCOS women when they used LDN in one trial. And then 49 out of 66 women with hypothalamic ovarian failure achieved normalization of their cycle and 18 of those women got pregnant. So again, when we talk about this, in relation to nothing else being controlled or everything else being controlled for, that's a pretty big jump when we look at some of those things. So we see benefits in psoriasis, eczema and different skin issues, the jama dormitology, systemic, systematic review found LDN safe and effective across multiple inflammatory skin conditions. So again, I'm not saying that if you have acne or if you have eczema, psoriasis, that LDN will absolutely heal everything, but it's absolutely something I would make sure that anyone dealing with those things would absolutely. I could say that's a someone that has struggled with acne as a young person and also as an adult person on my face when I was younger and then on my back as I've been an older person, LDN is absolutely a game changer when it comes to acne. And I notice a much, much better response from LDN in terms of suppressing acne. And for the most part, I'm acne free now, but I will have like little flare-ups here and there. I think a lot of times that's related to just hygiene around like maybe I trained to the gym one day. And if a gym that I went to didn't have showers had to drive my car 20 minutes home to get in the shower. And so sometimes there's like kind of that best ring of sweat. But anyway, let's talk about dosage. So you got to be kind of careful with the dosage because if you start too high too fast and get some weird side effects, again, nothing dangerous, but just something that's probably not pleasant. So you really have to allow one to three months to see meaningful results. Stanford based on their trials recommends at least two months at Target Dose before assessing the efficacy of hasn't done anything at all. And most people right away you're going to get some vivid dreams, although those tend to subside after you normalize to the use. Morning dosing is a good alternative for those people. I will say in my experience having worked a lot of people, I say like 80 to 90% of people do really well with it at night. And then there's like 10 to 20% of people, probably one or two out of 10. They just don't do well with the night. But if they take it in the morning, they're fine. They don't get sleepy. I wouldn't say that no, Tractone necessarily makes you sleepy, but I would say if if you do, like if you if you could pick one night would be a little bit better because you tend to get again that cycle of the endorphin release that kind of carries over into the next day and helps you. Feel well. So typically what most people do, the titration schedules are different. Most people start at 1.5 milligrams. You want to do that for at least one to four weeks before you jump up to three milligrams. And again, that another one to four weeks. And then if you do well with that, you could try to go up to five milligrams. And then just stay there. I personally have gone from 1.5 to three to 4.5. I find three milligrams to be my sweet spot. So for me, 4.5 milligrams tends to be a little too stimulating at nighttime. For me, where's three milligrams is perfect. I fall right asleep. And then again, always use immediate release. So never slow release. The rebound mechanism depends on it clearing in those short hour windows for the cascade to happen after that. And then again, just make sure if you're sensitive to fillers, if you're getting compounded, that you don't have any. Since of that, especially in the case of LDN, when a lot of the people using it might have some sort of a action going on there, looking at side effects, I'd say when you've documented about 37% of people get vivid dreams, that's a very common thing to see 0% adverse events. So again, when we look at this, even a 2019 meta analysis confirmed no excess adverse events versus placebo, which is pretty interesting. Again, for people that get mild headache and nausea, that usually resolves within two weeks. I would say any of the weirdness usually goes away after two weeks. FDA hepatocyticity warnings based on 300 milligrams a day. Again, that's way higher than even the dose being used for opioid withdrawal, which is 50 milligrams. The one heart of contraindications, because I do ask this question more than you would think, the concurrent sustained release opioid use requires a seven to 10 to day washout. So if you are using opioids, the recommendation is to not use those concurrently. You want to make sure those are out of your system and then transition over to LDN. Also, there was a doctor. He used LDN through 37 weeks of gestation and over 2000 pregnancies without reporting complications. I'm not going to tell you if you're pregnant, whether or not to take it. And so just use your discretion and work with your doctor. Now, onto the fun part, talking about LDN and hormone replacement therapy. Not only is LDN okay to take with your hormone replacement therapy, but it's actually potentially synergistic through multiple pathways. So let's look at what those are. When we look at inflammation, so chronic inflammation disrupts receptor sensitivity to the exogenous hormones we're taking. It can also increase SHBG. That's another thing for men and women. It can be a massive, I would say interrupt or a disruptor of their hormone therapy is how high their SHBG is or even it being too low. And so we can we can modulate that with LDN because of helping with inflammation. We can also for people that are overexpressing to a rheumatase, which I will acknowledge can be a real thing. And some people, although I'm a proponent of estrogen, I will acknowledge that people that have lots of inflammation and inflammatory visceral fat, they can overexpress a rheumatase, which can lead to not so good side effects from their hormones. And also some of this inflammation can impair thyroid conversion. So LDN's reduction of interleukin six TNF alpha interleukin one beta and 14 other markers, clears the road for hormones to signal properly. So again, just going to be one of those things. It kind of heals the environment for the hormones to help do what they're supposed to do in the right way. When we look at Hashimoto's and thyroid optimization, so LDN addresses the autoimmune component directly. It reduces antibodies and slows thyroid destruction. So again, a phase two RCT with LDN was registered in 2025 looking at thyroid. So again, we don't have the data back on that. We are seeing a lot of correlative good data between LDN and thyroid. We look at estrogen and progesterone. Women show greater HPA, which is their hypothalamic pituitary adrenal axis response to now trex on the men. So again, men can use it. I use it personally, but it just seems to have an a more outsized effect in women because of this effect. Especially at high estrogen phases of their cycle and LDN's anti inflammatory benefits, complement estrogen's own properties and may improve receptor efficiency for their estrogen. We also look at PCOS and fertility, LDN blocks, opioid tone driving abnormal LH pulse utility. And it normalizes LH and FSH ratios, reduces, reduces if for people that have PCOS where there are androgens and estrogen drought out of balance, it will help normalize that ratio and also ford is all and improves insulin sensitivity. So again, it's going to help a lot of cases with that. We look at LDN for HRT and men. It's going to help disenhibit the HPG axis, which is the hypothalamic pituitary gonatal axis, stimulating LH and endogenous testosterone and a male recess monkeys. All those is significantly stimulated LH and testosterone within 20 to 60 men X and it's mechanistically complementary to clomophenin and clomophenin. Again, whether you're maybe just using a clomophenin or you're on TRT, you're or going to get benefit from it. Interestingly, for sexual function, there was one study that 11 out of 15 men with idiopathic impotent showed improved erectile function from LDN via the central endorphine mediated or worse signaling, not the hormone change. The hormone stayed stable. So it's usual for men with good testosterone levels, but suboptimal sexual function. I would say that's one thing. You hear a lot about guys on TRT not necessarily having the best sexual function or maybe it's really good for year two and then their sexual function tends to decline. I think LDN, although not in every case, is it going to be a savior? No, but it could be very beneficial for sex drive for some of those men that deal that way. Also, for chronic inflammation, again, to go back to SHBG, the drives impaired oromatase conversion, impaired angiogen receptor sensitivity. LDN cytokine reduction helps testosterone work more effectively at the receptor level. If levels look good on paper, but you feel suboptible inflammation may be the bottleneck. A lot of guys don't realize that they think, and rightfully so, that all of their illness can be solved with hormones. And that's true in a lot of cases, but sometimes there's still this lingering inflammation, again, whether it's from obesity or environmental toxins or autoimmune disease or whatever, that LDN can help address to make the hormones work better. And then at low doses, the endorphin rebound is proposed to normalize HPA axis function rather than chronically stimulated, especially relevant for men whose testosterone issues are secondary to chronic stress. So again, I've dealt with this in the past like no amount of hormone therapy for me can change the fact that sometimes I'm stressed out and sometimes I can have impaired adrenal function. And so LDN is one of those things that can help modulate and normalize some of that adrenal function because my cortisol will be completely shot, you know, especially depending on different things that I have gone past with stress. So I've found LDN to be very beneficial in those cases. Now, when we look at peptides, it's pretty cool. So again, there's no published RCTs for LDN plus peptide combos. However, what we're going to talk about is individual agent data with some of the more common peptides. So one, we have TL4 or agonism, remember, or TL4 antagonism, which dials down the overactive innate immune director. So we get less injections, site inflammation and mass cell degradation from our peptides. We see increased T regs, which shift the adaptive immune system toward tolerance, reducing anti drug antibody formation. What that means in principle is that a lot of times LDN can extend the efficacy of our peptides, whereas maybe like eight to 12 weeks after using a peptide, we completely down regulate to it. LDN is actually going to help modulate that immune response to the peptide, potentially extending the shelf life or the window that we can use a peptide on. And I wouldn't recommend into getting this game of using LDN just to extend the life of peptide that you're using. However, it can be very beneficial for that in some cases. We also get lower systemic inflammation, which raises the threshold for triggering unnecessary immune responses to our peptides that we're injecting. It also enhances dendritic cell maturation, making the immune system more discerning and better at tolerating non-pathogenic antigen. So let's look at some specific peptides. And again, the I talk about every peptide with LDN would be outside the concept or the scope of this video. However, I just took some pretty common ones and talked about like, okay, what can we do with these? So we look at LDN and BPC 157. This is a very compelling pairing when we look at peptides and what they can do. Both improve gut barrier function through complementary pathways. LDN reduces stress and BPC upregulates tight junction proteins. And there's complementary nitric oxide modulation, which is ideal for gut permeability and inflammatory bowel disease. And we have LDN and TB 500. Complementary at different levels, TB 500 drive cellular repair via actin sequestration and angiogenesis, which is the formation of new blood vessels. And then LDN operates at the neuroimmune level. So LDN provides the anti-inflammatory environment. Then TB 500 handles the tissue repair when it's at LDN. It helps bring down the information. I think that's a very important thing to talk about because I get a lot of people that are like, hey, I did this to my shoulder and BPC and TB 500 don't work. What's going on? And a lot of times, all those those can be very helpful. And sometimes they're the only thing we need. Sometimes there's still too much inflammation at the side of the injury or the pain. Then these would be brought down. That's why KPV pairs really well. That's why LDN helps kind of accentuate those peptides. So we look at G8s of creatiogs. So separate dosing by two to three hours. LDN at 9pm and then peptides, maybe closer to bedtime if you're going to bed at like, you know, 10 to 11. So LDN may translate blunt the GH pulse during blockade, but amplify subsequent pulse utility. So again, you might not want to take them right together. But they can be enhanced response to the IGF 1 and IGF BP 3 appear unaffected by LDN. So again, they work synergistically there. Just bring you down inflammation. And then we look at GLP 1 agonist. There was rationale for contrary, which is FDA-proofed naltrexone. Plus be proper for obesity, LDN blocks, hedonic eating. GLP 1 targets homeostatic hunger. And together, they address both both types of hunger systems when we talk about overeating. And then over overlapping anti-inflammatory metabolic benefits, I would say actually if there's like one peptide or two peptides that LDN is very comparable to and just in terms of what it does, it's the GLPs and your immune peptides. So GLPs are going to help with a lot of the same things that LDN is helping with. Same thing with your thymus and alpha ones of the world because that's what helps bring down this immune response. And the cool thing about LDN that I've noticed from my GLP use is that I can stay at a lot lower dose and just get those benefits at a longer clip than most people. So there's most people say they start two milligrams of TERS or RETA. They use it for a while, let's say four to a week and all of a sudden the two milligrams doesn't do anything. Soft losing fat, they stop getting appetite suppression. Well, introduced LDN, it may be 1.5 milligrams or three milligrams. And now all of the sudden, you're better able to get the appetite suppression of fat loss at that dose for longer. Now does that mean you still won't have to titrate up no, but maybe it takes like 12 to 16 weeks before you get to that point that may be for you. And I think that's powerful because it allows us to you are lower to use a lower dose because we're healing the environment and the body, we're modulating the immune response to the peptide, which again, keeps us at a lower dose and then maybe it helps us avoid some of the side effects that people get from doing higher doses. Again, thymus and alpha one, another great pairing. This is the most immunologically logical combination for autoimmune conditions in TA1, stimulate CD4 plus T cell differentiation LDN shifts TH2 to TH1 balance and both reduce TNF alpha and interleukin 6, which addresses immune dysregulation and neuroimmune levels at the same time. We have LDN and KPV, like I mentioned a second ago. So this is the most direct mechanistic convergence via NF capa B inhibition. So KPV targets inflamed intestinal cells via PEPT1 transporter and LDN inhibits NF capa B through TLR4. So LDN's blockade may also increase in dodginous alpha melanocyte, hormone, melanocyte stimulating hormone, which is KPV's parent molecule. Pretty cool. So we do see mechanistically that LDN actually raises alpha MSH, which again, KPV is kind of like a fragment of it above. And we see LDN and C-link and C-max. So C-link actually inhibits in K-in-Kefelin, always mispronounce, however, in Kefelin degrading enzymes, LDN upregulates in Kefelin production. So more production, E-golast degradation, which results in significantly higher sustained in Kefelin levels and both reduce pro-inflammatory cytokines and modulate GABA urge signaling. So we have a clean combination for anxiety, cognition, and neuro inflammation. I think that's one thing that a lot of people don't realize or talk about enough with LDN is how much it moved. An anxiety. Then we have SS31 with LDN. Again, SS31 is one of my favorite peptides. I would say a top three or top two peptide targets by the control function via cardiolipin binding. LDN reduces the cytokine, and burn it, and damages the damages might occur, it impairs electron transport chain efficiency, so non-overlapping pathways addressing cellular energy energetics and neuroimmune dysregulation. Again, you see a lot of improvement around chronic fatigue, long COVID, and with those two combos. And then just to sum up, LDN is the definition of a support molecule. Is it going to do all the things that our peptides do? Absolutely not. However, it does one dramatic thing. It's 20 subtle things that make the rest of your protocol work better. And I think for the person that is optimizing that is using peptides in an intelligent manner, that is using hormones in an intelligent manner, LDN can be one thing that maybe you feel better, but maybe there's like that last five to 10 percent that LDN can come in and just make everything better. And I know in my life, it has, and I would even say for the person, most of you guys out there or what I would call high for high performing people, you wouldn't be in this world if you weren't, you wouldn't be seeking all the things that you're seeking in the peptide world. I know a lot of people come at it from like having to heal something major in their life, but then a lot of people too are always looking for the next best thing, which hey, I get I'm one of those people too. And that's where LDN is going to come in and maybe be that last five to 10 percent. They're not only has its effects, but also makes everything work better. So again, just to sum up, clear side inflammation modulates our immune system, upregulates endorphins and reduces neuroinflammation. So again, we don't have a ton of trials specifically with HRT and peptides. However, it is something that I think is highly beneficial. So that is it for the slides and those are the studies. If you want to look those up, you can look at that. And that is my update for LDN and 2026. Hopefully that was helpful to you. I did go a lot deeper on this presentation than the last one I made just because I wanted to bring in some more data to kind of support those things and also talk about it more in the context of hormones of peptides. Now, I mentioned the fact that you can use LDN to kind of extend the response that you're having to a peptide. I would advise against going into the LDN game just to say, hey, I want my redder or my tears to work longer and not have to titrate up the dose as fast. You could do that, but I just would not recommend playing that game. I would think of LDN as something that you would bring in to help everything do better. Now, the one question I specifically didn't include in the slides because I just wanted to share my personal experiences. The idea of cycling. So the last couple of years that I've been using LDN, I've gone back and forth between using it three months on and three months off. And I felt great doing that, but I just noticed that when I was on, I felt so much better. It's not that I felt bad when I was off. I just felt so much better when I was on. And so what I've been doing, I've been, it's probably been the last eight months. I've just been using a consecutive consecutively every night, three milligrams. And I have only noticed benefits. So I'm going to try it probably for about a year total and then maybe come off just to see if I notice any difference. But I do think in the past, I was probably more of the opinion, use it three months on, use it three months off. But now looking at a lot of the literature is out there and just my own personal experience. And then a lot of other people that I talk to inside my group who use it all the time. I think it is one of those things that I would kind of move into the category as something that I would use every day. So again, that's just me personally. I would recommend that if you're going to try it, maybe try both, use it for three months. three months on, three months off the start, see how you feel, and then you can kind of play with it over time and see. Again, the great thing about it is that it's very affordable, very easy to find. If you know what you're doing, and it can be used to enhance all the things that we're already doing. So, again, thank you guys so much and closing. I am so blessed and honored to get to bring these messages to you. You have no idea what a dream come true. It is for me to be able to do these and kind of bring these things to you. So thank you guys so much, you know, whatever shape, form, or fashion it is that you support me, whether it's through just using my code of places, being on the email list, sharing this with friends and family, liking, commenting, and all that stuff. I promise you that goes so much further. You know and helping support me to bring these messages to you. So thank you guys for that. I know it gets a little redundant if you listen to all my stuff, but I just want to always make sure you know that because without you guys, I don't know. So that's it for this one. Let me know your comments, thoughts, and feedback in this, whether this has been helpful I will see you guys in the next one. Peace.