Speaker 1FanDuel is now available everywhere in the U.S. So you can get in on the sports action no matter where you are. Including these places. Make this your most rewarding season ever with FanDuel. Age and location restrictions apply. Product availability varies by market. See FanDuel.com for eligibility. Gambling problem? Call 1-800-GAMBLER.
Speaker 2Late night bites with friends? Already hard to beat. That first too hot bite of fries you couldn't wait for. Followed by ice cold Pepsi. Now that hits different. Suddenly, the energy kicks back in. The night goes longer. And the laughs don't stop. Because Pepsi brings out more flavor, more fun, and more of the moment. Food deserves Pepsi. Grab a Pepsi Zero Sugar today.
Speaker 3Today's talk is very controversial, okay? You're not going to get a cardiologist talking about not eating and fasting. So this is a little unusual, but this is breaking ground. Because we're always looking for new ways to treat old diseases. Treating diseases or illness, nature has to have built something in there. People got better. People got ill, people got better. Some people, of course, died. But there must be mechanisms built into the body that make you better. And what I'm trying to do here is to tap into nature to see if there's anything in fasting. First, I heard about it going through medical school. I said fasting can't be, fasting can't work. Fasting obviously does nothing. People didn't eat because they didn't have food. They fasted because the priest told them not to fast. They were fasting because they had seven children and food for only five. But the more I studied it. And looking at the biochemistry. Being a scientist, I got to substantiate a lot of the things that I say. And if I'm going to look at the mechanisms, I can't just come up with them. I got to look at the biochemistry behind it. So what I've done here is I've made a summary, pretty much. And I have no slides today because I was in surgery right until late afternoon. I never got a chance to finish off my slides. But I promise you all that just like the last two ones. This is being recorded and we'll put the slides in later on, maybe in the next week. And then we'll put it up as a proper slide presentation with the lecture in the background. So it'll be just like the previous ones. I hope you all enjoyed the previous two that are already on YouTube. So, so with fasting, if we look back in history, we've been fasting all along and Socrates was asked why he fasted and he fasted for many years. And he said he fasted for many years because he needed mental clarity. So do you get mental clarity when you fast? Well, he certainly did. And yet the prevailing wisdom is that when you fast, oh, I'm going to get sleepy, I'm going to get tired. I need energy. And there's energy bars. There's those little drinks, energy drinks. And when you drink that, you're supposed to get energy. And it's not true. When you go and take a candy or an energy bar, you don't get energy. You're supposed to get energy. And it's not true. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy.
Speaker 1When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy.
Speaker 4When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy.
Speaker 1When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy.
Speaker 2When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy.
Speaker 3When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. When you go and take a candy or an energy bar, you don't get energy. We'll be right back.
Speaker 1So you can get in on the sports action no matter where you are, including these places. Make this your most rewarding season ever with FanDuel. Age and location restrictions apply. Product availability varies by market. See FanDuel.com for eligibility. Gambling problem? Call 1-800-GAMBLER.
Speaker 2The perfect lunch combo. That first bite of your favorite sub, followed by ice-cold Pepsi. Add a couple of friends, and now that's next level. Suddenly, the laughs get louder, the stories keep flowing, and the food tastes better. Because Pepsi brings out more flavor, more fun, and more of the moment. Food deserves Pepsi. Grab a Pepsi Zero Sugar today.
Speaker 3It is so processed, and yet now, we consume that like it's going out of style. All of you consume vegetable seed oils, whether you like it, or not, because it's in all processed foods. And yet that food, if you look at your entire evolution as 24 hours, that food only came to you in the last 10 milliseconds. How do you expect your body to respond genetically and hormonally to that food that you only just introduced to your genetics? So before you put anything new in your mouth, you've got to decide, that is this in keeping with my genetics? So really, this is very thought-provoking. Even agricultural products is very thought-provoking. Agricultural products are fine, but what did we do with them? In the year 1880, we invented the steel mill, and we made the flour. And when we made flour, we changed the glycemic index of the food completely. And that was a study that I talked to you all about before also. So we've changed as we've moved along. So our diets have completely changed. The Paleolithic being ate maybe once a day. And he ate during the daytime, by the way. Because if he tried to eat at nighttime with the carcasses outside, the hyenas or some other animal will want to share that with you. Probably make you their meal as well. So at nighttime, you have to crawl into your cage. I mean, into your cave. You've got to crawl into your cave and stay there. And don't come out to drink water either. But no, we take the bottled water with us to bed. So, our body is made to fast and is made to feast. And I will convince you tonight that you should be fasting and feasting as well. Because if you don't fast, you're not going to be able to eat. You're not going to be able to eat. You're not going to be able to eat. You're not going to be able to eat. You're not going to be able to eat. You're not going to be able to eat. You're not going to be able to eat. You're not going to be able to eat. You're not going to be able to eat. You're not going to be able to eat. Because if there was no food around, and if your sugar just went down, down, down, down, down, your energy level went down, down, down, you'll be dead in 24 hours because you'll go into your cave and you'll just crawl in there and you're just going to get terrible because nature doesn't give you any way to come back. Oh, there's been no food for 24 hours. I'm just going to crawl here. I have no energy. I have no nothing. I'm just going to crawl and die. But no, that does not happen to you. Fasting doesn't kill people. And in fact, I, I, I, I, I ask you to fast all the time and I ask you to come for a stress test. Well, you don't come on the stress test and die. So, so this, we are used to fasting and we do it. And when you're sick, you fast, don't you? When you have the flu, you don't eat. When your pets are sick, they don't eat. You don't see your dog running and eating his food when he's sick. He stays in the corner and he does not eat. There's a wisdom in that and that wisdom is, is the physiology. Because the physiology of the body is saying that, hey look, you know, eating is dangerous. Eating takes up a lot of energy. Eating takes up, if you put in about 100 calories of food into your body, it takes about 60 to 70 calories of your body to digest that food and then you get a little excess. So eating is an energy consuming activity. But most of us don't think of it like that. You just think that all that eating is going to go away. It's going to go right in and do me all that good. There's a lot of energy that goes into it. Eating is dangerous. It's true. Eating is dangerous. So, once in a while, when you don't eat, nature has put into you a biochemistry.
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Speaker 4♪ I've been to Georgia, Houston, Cleveland, Minnesota ♪ ♪ Buffalo, Lincoln, Chi-town, Arizona ♪
Speaker 1Make this your most rewarding season ever with Vanduul. Age and location restrictions apply. Product availability varies by market. See Vanduul.com for eligibility. Gambling problem? Call 1-800-GAMBLER.
Speaker 2The perfect lunch combo. That first bite of your favorite sub, followed by ice cold Pepsi. Add a couple of friends, and now that's next level. Suddenly, the laughs get louder, the stories keep flowing, and the food tastes better. Because Pepsi brings out more flavor, more fun, and more of the moment. Food deserves Pepsi. Grab a Pepsi Zero Sugar today.
Speaker 3So let's just dive right into that biochemistry a little bit. So the first thing that's gonna happen is that you stop eating. In the first 12 hours, your body's gonna say, "Hmm, no food coming out." It's gonna wipe up all the glycogen that is in your liver and in your muscles. That's a normal process. It's gonna use glycogen. So your sugar level or your glucose level will be maintained. What about protein? You got plenty protein in your body. What about vitamins? You got at least a month's worth of vitamins in your body. What about energy? How much fat do I have? Do you know that I have enough fat in my body to last me at least 40 days? So I have plenty energy, and I have about 50,000 calories stored inside me, which can be used, but I need to unlock those calories in the form of fat. So you eat, you store in the form of fat, and that fat should be utilized now. So for the first 12 hours, I'm not gonna use the fat. I'm gonna use up my glycogen stores. How am I gonna feel? I'm gonna feel okay, unless I'm a junkie. Then I'm gonna want to eat. That's junkiness because your sugar will never drop. I'm gonna say that again. Your sugar will never drop. You can fast for seven days. Your blood sugar will come down, but you will not become hypoglycemic and have an attack unless you're on insulin or you're taking diabetes medications. So how does the body keep the sugar up? Well, I told you that in the first 12 hours, you get glycogen. After 12 hours, what happens? You get gluconeogenesis. That means new glucose is being made, gluconeogenesis. Where does that glucose come from that comes into the blood? It comes from the blood stream. Where does it come from? Comes from protein. But it's not the protein in the muscles. Protein is always being turned over in your body. But this time, the protein that's normally gonna turn over turns into glucose. So your glucose level is maintained for another 12 hours or so. During this next 12 hours, there's a small increase in ketosis. So let me explain ketosis to you. Where does that come from? So what happens is that the body senses that you have very little food coming in. And I'm gonna explain to you how that happens. How does the body know that there's no food? It's not just the sugar. I'm gonna explain this to you. It's not sugar. So what happens is that now the fats in your body say, "Okay, we are here, utilize us." The only way fat can come into utilization is the insulin levels must drop. Insulin levels are now low, because you're not eating. When your insulin level is high, you store energy. When your insulin levels are low, you pull energy out of the fats. So now, through the hormonal action of hormone-sensitive lipase and the action of LPL, what happens? The fat stores open up, because your insulin level is low. So the fats start being devoured, and the fat gets converted to triglycerides and fatty acids. The fatty acids flood the bloodstream. You can't utilize fatty acids, so they go to your liver. And in the liver, your fatty acids get converted to ketones. There's two ketones, beta-hydroxybutyric acid and acetoacetic acid. These two ketones now go up. Ketones can be utilized by the body. And this is the great breakthrough that I wanna tell you, that ketones can be utilized by every cell of your body, including your brain. You are told that the brain is an obligate glucose utilizer. It can only utilize glucose. It's absolute.
Speaker 1- FanDuel is now available everywhere in the US. ♪ I've been everywhere, man ♪ ♪ I've been everywhere, man ♪ So you can get in on the sports action no matter where you are, including these places.
Speaker 4I've been to Georgia, Houston, Cleveland, Minnesota, Buffalo, Lincoln, Chi-Town, Arizona.
Speaker 1Make this your most rewarding season ever with FanDuel. Age and location restrictions apply. Product availability varies by market. See FanDuel.com for eligibility. Gambling problem? Call 1-800-GAMBLER.
Speaker 2The perfect lunch combo. That first bite of your favorite sub, followed by ice-cold Pepsi. Add a couple of friends, and now that's next level. Suddenly, the laughs get louder, the stories keep flowing, and the food tastes better. Because Pepsi brings out more flavor, more fun, and more of the moment. Food deserves Pepsi. Grab a Pepsi Zero Sugar today.
Speaker 3You can utilize ketones. After a 7-day fast, up to 70% of the energy utilization of the brain is through ketones. And the brain likes it. And there's even studies to show that when the brain utilizes the ketones, it actually is a cleaner burn. It burns more cleanly. So what happens is there's a slow increase in the ketones, which actually starts around 18 hours and gradually goes up, up, up, up, up, up. So by 24 hours, you have some ketones, maybe 10, 15% of your entire energy source is now going to be ketones. How are you going to feel with ketones? Just fine. No problem. You feel okay. Because ketones are giving you all the energy that you need. Then, let's say another 12 hours go by. So you're now at 35 hours, let's say. Now, the ketones go even higher, and higher, and higher. And by three days, your ketone levels are really beginning to get even better and even higher. So by the fifth day of fasting, you will have a lot of ketones. Now, you can measure your ketones in your urine. So you get a little dipstick. And you can buy this, by the way. It only costs a few dollars. And you just test your urine to see when you become ketogenic. And you can test it. Now, if you've been on a low-carb diet, low-sugar diet, you will go into ketogenesis earlier than somebody who eats a lot of sugar, because he's got a whole bunch of glycogen in his liver. Because you've got to remember, go through the glycogen first before you start burning ketones. So someone who's on a very low-carb diet, he'll go into ketogenesis much faster. So it's the ketones. And the ketones will keep getting utilized. The fats will keep burning. So now-- Now, you're doing the right arithmetic. That, OK, fine, I've used up my current account. So I'm going to my deposit account now. And I'm drawing money from my deposit account. Now, what prevents us all from utilizing my deposit account? It's insulin. Because I told you, insulin holds the key to opening up the fat stores. So you want to utilize your fat stores, you have to drop your insulin level. Now, how am I going to drop your insulin level? There's only one way for me to drop your insulin levels. And that's to put you on a fasting program. So now you choose which fasting program you want to be on. Do you want to do alternative day fasting? Do you want to do 18-hour fast? Do you want to do three-day fast? I mean, how do you want to do this? And that's something we'll talk about and see what can. But what am I saying here? What's the trigger here? Which is the hormone in the body that's the elephant in the room? It's insulin, just like my last talk I told you about. Do you see how it's all coming together? The fats, the sugar, the weight, the fasting? It's all insulin. It's all about insulin.
Speaker 5So if somebody is taking insulin, how does that affect them?
Speaker 3You're doomed.
Speaker 6But there will be more.
Speaker 3So somebody who's taking insulin, show me somebody who takes insulin every day. And oh, yeah, I can lose weight just like that. They can't lose weight. They cannot. I've done it. I've given insulin for 25 years to my patients, and I yelled at them, and nothing happens. So long as the insulin levels are high, they cannot lose weight. And let me tell you something else. The mortality is also higher.
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Speaker 8This is US Bank's Cozy Cashformations with your chief financial playmaker, Fernando Mendoza.
Speaker 5Fernando Mendoza: You are worthy of financial security. Budgeting is not restriction, it's freedom. You are smart. You are capable. You are giving your money a purpose. You are learning the language of saving, of growing.
Speaker 8Now streaming. Member FDIC. Copyright 2026, US Bank.
Speaker 3Fernando Mendoza: Now I'm talking about type 2 diabetics, okay? Not type 1 diabetics. Now type 1 diabetics are insulin deficient and they need the insulin replacement. But type 2 diabetics already have a high insulin level and they have insulin resistance. So the insulin levels are already high and now you're giving them more insulin. And that is only going to hurt the patient even more. But your A1C will look better and your glucose will be lower. But show me the data that your survival is going to be better. Show me that you're going to get less Alzheimer's. Show me that you're going to get less inflammation in your body, coronary artery disease, stroke rates. It's all about the insulin, guys. It's all about the insulin. So you've got to, in a chronic state, now when you're in the hospital and you're having DKA or some other medical problems and you're having surgery and you're getting on steroids and your sugar levels are high, I'll give you insulin. But that's a temporary thing to bring it down because I want your sugar levels to be ideal while I'm doing surgery on you because high sugar levels mean poorer recovery. So I want your ideal sugar levels. But that's a different story. I am talking about people who have high insulin levels because they have insulin resistance and you cannot give them more insulin. So you must get your insulin level down. I don't have a drug to give you to bring your insulin level down. But fasting will bring your insulin level down. Because if you don't eat, you're not going to make insulin. Now what's going to happen is that as your insulin level drops and it's nice and low, your body will become sensitive to the insulin. Just like when any level goes down, you become sensitive to it. When there's too much of it, your receptors down-regulate and say, "I'm not going to respond to this." So after you eat in a normal state, you produce a lot of insulin, let's say. Now that you've been down for a good period of time, let's say I'm going to give you an example, 24 hours, your insulin levels have been low. Now you eat that next meal, you're only going to make this much insulin. You're going to make a much lesser amount of insulin. So your body is going to deal with that meal differently than had you eaten in a fed state. So eating after a fast is metabolized totally different than eating in a fed state. It's much more forgiving to you. And what's going to happen is that you'll produce less and less insulin even in the next few days after you've fasted one day. Look at the rewards I'm telling you about. You ought to diet at least one day where you don't eat anything because it will give you a sustained benefit for days because your insulin sensitivity is going to be improved. So what happens here is that insulin stays nice and low, your body becomes more sensitive to the insulin, produces less insulin, so you're not locking the fat stores, and you keep burning fat, which is what you want to do. So here's a reason to fast if you're overweight. You want to get rid of the fat? Fine. This is the way to do it. Well, why don't you just do caloric restriction? So you still eat five times a day, but eat small amounts. You cannot do that. You lose a little bit, but you lose much more muscle, and you lose some fat. You will feel miserable. Your metabolic rate will go down, and your body resets itself, and you'll gain all that weight right back again because that's not natural. A paleolithic being, you don't just go and nibble at the carcass and say, "Okay, I'll come back here and eat five times this little carcass." No, you don't do that. It's just totally unnatural to do that. And the body's physiology is in keeping with that. So the biochemistry is telling me the same thing, that, "Yeah, you're not supposed to do that." So you're supposed to eat when the food is available, which is usually once a day. Now let's say, what other benefit am I going to get? Besides the insulin and utilizing the fat? Well, the body says that, "Okay, this poor person hasn't had a kill today, so he's crawled into his cage. Well, I've got to get him out of there." Can I get him out by decreasing his metabolic rate? No. I increase his metabolic rate. How do I do that? After a fast or during that fast, especially after 18 hours, your epinephrine levels increase. Your adrenaline levels go up. Your cortisol levels go up. Your metabolic rate goes up. You start feeling better. You start feeling more bushy-tailed, bright-eyed because you're looking for your next kill. Because if you walk out there with your eyes half-dry, you're going to get a heart attack. you're not gonna see the kill the deer will roll walk right by you and you won't have any energy to chase it but now you're full of you pumped up your metabolic rate is high you're more alert you're awake and you will get your kill there's another thing that happens when you're fast you produce a stuff called beat brain-derived neurotropic factor so what happens is that the body starts producing a hormone that goes to your brain and tells your brain switch on and you actually make new brain cells you actually make new brain cells show me a drug that's gonna make new brain cells so in a fasting stage you actually make new brain cells because nature wants to teach you that this is how you got into the situation learn from it remember it remember it and now get out and get another kill you see it makes you better it makes your brain better what else does a fasting do growth hormone so do you know how much growth hormone costs a small point one injection is about $400 point one point one is $400 it's so expensive right but did you know that if you fast just a one-and-a-half to today does a two-day fast in the study a two-day fast produced a two thousand percent increase in your growth hormone production in a man and thirteen hundred in a woman so it is the best way to boost your growth hormone level now why would I want growth hormone because growth hormone is the hormone that keeps you young it's the growth hormone that makes your skin better that replaces the dead parts better and your muscles grow and your muscles actually grow so you do you do 10 reps you're gonna put on more muscle than if your growth hormone is low growth hormone is low you could be pumping out all day long and you'll just get achy muscles but you will not grow muscles to grow muscles you need growth hormone you want to stay younger you need growth hormone now there is a condition called adult growth hormone deficiency and of course children have it too and they have short-term stature and slow growth etc and in adults is a similar one and it manifests itself as an elderly person who's just his muscles are all wasted he's got no energy he sees he's got a blank in his in his eye all the time he's just can't think and he's very weak he's just sitting around you measure his growth hormone level it's very low you give him some growth hormone he feels a lot better but the problem with exogenous growth hormone is has a lot of side effects so that's why right now it's not approved by the FDA for me to give people growth hormone but the best way to give yourself growth hormone is do one fast do one fast and your growth hormones will go up what else happens when you're fasting so growth hormone I told you about 20 24 to 48 hours if you really want to get the full benefit of growth hormone now there's a condition called autophagy I'm going to explain to you what autophagy is autophagy starts actually at about 18 hours and then gradually increases and it's maximum at three days sounds terrible it's not fair but you know what even if I get some autophagy after 24 hours I'll be very very very happy but if I want to maximize my autophagy I'll go for a three-day fast so let me explain what autophagy is autophagy the Nobel Prize winner got it you got two years ago got the prize on the top so what happens in autophagy is that when you are nutrient deficient like this the body senses that there's no nutrients coming in and there's a thing thing called mTOR mTOR levels go really really low this is a protein kinase in the body and it goes really really low and that turns on autophagy what turns off autophagy is mTOR levels are high what causes mTOR levels to go high is eating mostly proteins so let's come back again to autophagy so what autophagy does is that it takes your cells and the cell has a lipoprotein membrane around it and there's all the intracellular organelles in it but in the course of time those cells the intracellular organelles some of them become redundant this protein lying around this whenever this work there's gonna be garbage so that's what autophagy does it takes those intracellular organelles and some proteinaceous materials that are just lying around in the cytoplasm so the body says I need energy recycle I need to recycle so the first thing it does the cell stays alive and it takes those intracellular organelles breaks them down packages them into the lysosome and digests it breaks it down into its pieces so whether it's the cytoplasmic reticulum or other intracellular organelles breaks them all down and exports it out of the cell once it's exported from the cell into the bloodstream the bloodstream says aha I've got some new building blocks now and the body reutilizes that okay so the body now starts utilizing your intracellular organelles so you're recycling your cells so your cell is doesn't die it goes into a state of recycling and you recycle your mitochondria as well so mitochondrial parts because there's a lot of oxidative stress going on in the mitochondria so what happens is that it that cell is now going to be deplete of its old non-functional parts and then when you do it guess what gets repaired first all those organelles so you basically rejuvenate your cells now if you're constantly eating you will not rejuvenate those cells and the biochemistry is so beautiful that these cells now are functioning better they're younger and they are going to last longer they're more resilient also to disease I'll come to that in a minute I will come to that in a minute I'll come to that in a minute I'll come to that in a minute so autophagy makes your cells better younger restoration it's like it's like a reset switch so how do those organelles redo themselves well they rebuild themselves because when you then eat because you've had autophagy a signal goes from those cells to the bone marrow to say hey listen I used up my intracellular organelles when you get new ones new supplies send them to me so the bone marrow when you eat makes stem cells have you heard of stem cells now cost you a million dollars just go out and get some it cost you a whole lot of money and it won't work because when you inject stem cells from the outside the residents rates are wrong because they didn't get the message of where to go to it's all artificial so it doesn't know so the brain look I injected brain stem cells in the heart when patients myocardial infarctions I was here doing the study upstairs and what was the residents rate residents rate is how many of the stem cells actually ended up in the muscle where I wanted it to stay and repair the heart less than 0.1% did the ejection fractions go up no change in ejection fraction so injecting stem cells from the outside does nothing for you it was good to study stem cells and it still is for the reason that you need to harness nature's way of giving you stem cells you want a stem cell? transplant right now you're gonna fast it's the fastest way to increase your stem cells so these stem cells come out of the bone marrow it's called refeeding reward and they go into the into the organs and replenish cells that have died and change the machinery in those cells as well so there's a whole rejuvenation process you are a younger better more resilient person than you were before and this has all been documented over and over again but there's no industry that's going to support me because there's no financial gain if you get better and younger and live longer because there's no one there to make money out of no one makes money when you fast they lose money so boost your growth hormone boost your boost your your stem cells this has been very well documented not only in humans in animals too well documented over and over again it's just that nobody's ever heard of it anyone thinks that all fasting is just fasting is starvation is no good but there's so much science behind this so the next benefit of course is stem cell mobilization that occurs and to get the maximum benefit of that you can't just do you know overnight fast no you really need to fast because for the bone marrow to say I'm gonna come in and replace you've got to really have reached that point of replacement so you can't you can't speed it up either so the question is can I do a three-day fast of course I can do a three-day fast you've got to prepare yourself for mentally you got to prepare yourself physically for the environment make sure that you know you're you know you're you're with your best friends it's an environment and you got to have water so that you don't get dehydrated so you can't do it all of us can do it so you can fast for different reasons so when would I want autophagy I would want autophagy one just to live longer number two let me tell you something if you do a seven-day water fast the studies done in Boston at the University showed that your lifetime probability of getting cancer is reduced by more than 70% some studies even higher because the cells that are going to die off in the state of the fast are going to be your cancer cells because your cancer cells are going to die off in the state of the cells look if I want to do a PET scan on you I'm going to give you radioactive material it's got glucose in it excuse me the glucose is really low and the insulin level is very low so the nutrients that the cancer cells want are not there cancer cells do die off so let's talk about cancer for a second so the studies have been done and if you fast a person only for 36 hours that's it and then give them chemotherapy in that state they're going to tolerate the chemotherapy better they're going to have less side effects from the chemotherapy it's going to be death of cancer cells and your normal cells are more resilient now and you're going to get less death of your normal cells do you understand what I'm saying so what happens when you're fasting your normal cells become more resilient so when you give the chemo only the weak guys die which is the cancer cells because you've strengthened through this fasting process your normal cells so I wanted to do this protocol upstairs in in the bone marrow unit where we do a lot of chemotherapy on these patients but no nobody said okay we want to do this project they said it would be inhumane to tell our patients to fast before we give them chemotherapy so what we do we feed them then they get nauseated then they vomit so we give them zofran and then we then they were still don't do that so then we'll put tpn on them because we give them chemotherapy and then we give them tpn on them because we give them tpn on them because we give them tpn on them because we've all been indoctrinated that we have to feed feed feed feed feed I'm just telling you all right now if any of you get a man kind of in function you get admitted to the hospital I'm making your NPO I'll put IV fluids on you I'll give you I'll make you NPO so even if you do vomit you're not going to aspirate you know how much aspiration you see in the hospital over here and pneumonia and all that from aspiration is terrible because I'm force-feeding you in a sense wait a second your body is not hungry don't eat but no the trays get bored to you have to eat you don't have to if you the trays get bored to you have to eat you don't have to if you the trays get bored there's a reason why you have anorexia when you're sick pay attention to your body your body's telling you don't eat then don't eat you won't die you might die from eating so cancer I predict that in the next five to ten years there's going to be major cancer treatments associated with a jump to fasting and that's coming definitely it's on its way what else can be done in the next five to ten years there's going to be major cancer treatments associated with a jump to fasting and that's coming definitely it's going to be major cancer treatments associated with a jump to fasting and be useful or two immune diseases there's numerous studies to say that you have inflammatory bowel disease rheumatoid arthritis lupus any of these conditions and you get a flare-up of it fast for three days it's the most potent thing you can do as an anti-inflammatory because first and foremost your bowels are totally quiet there's no energy being used for digestion your body's energy resources will be utilized to repair yourself a lot of autoimmune diseases start from your gut as well gives your gut a chance to heal so that you get less leaky gut syndrome so that that fast actually heals it gives you your gut a chance to heal as well autoimmune diseases get better then what about diabetes diabetes definitely gets better because I just told you the insulin resistance gets better so that gets better what about Alzheimer's oh yeah you know poor granny we can't pull the tray away from her but sometimes that's the best thing you could actually do give her lots of liquids and don't feed granny for three days if she's got dementia social services will be after you it could be anybody not just the granny but don't feed her for three days just give her lots of water I promise you neurologically she'll start waking up the fog will go away the confusion will get better it can get better and it should get better and there's no harm in trying because she won't die in three days so three day water fast so what I mean by the water fast three day water fast that means you can only drink water for three days so drink lots of water now why do you need to drink so much water because all reactions occur in water and secondly you'll pee a lot when you're fasting I'm not drinking that much I'm not eating and how come I'm peeing so much it's because when you're in insulin levels go down insulin holds on to water now there's no more insulin so that water gets diuresed out of your body so you will notice that you pee a lot so you need to drink more when you're fasting that's number one now what about electrolytes well electrolytes will be conserved by your kidneys your kidneys are very good at holding on to electrolytes so there's plenty of electrolytes in the body do you know that if I have sodium if I don't take in sodium the last molecule of sodium will be reabsorbed by my kidneys not a single molecule will be in my urine that's how good it is so kidneys will take care of everything the kidneys will not allow you to lose sodium or potassium now if you're already starting out with a half empty plate yeah you may get some depletion but you can get that tested and on refeeding you I'll give you some clues on how to improve that when you refeed yourself but it's unusual to get electrolyte imbalance but if you do get it take a pinch of salt in the water and you'll find that your cramps get better and your dizziness gets better and your headaches get better so these are complaints a lot of patients have that oh you know I was fasting but mine after about 15 hours I had a bad headache well go and drink more water with a little bit of salt in it and put Himalayan salt because that also has some magnesium and other things in it and you'll feel a lot better dizziness is usually due to low blood pressure because your blood pressure comes down so you get dizzy when you're fasting it's not because your sugars down is because your blood pressure is lower drink water and cramps some patient gets cramps put the salt again and also in the evening put yourself in a tub of of Epsom salts or you can get some magnesium and there's there's a liquid magnesium you can just put on your skin you can spray it and that'll give you magnesium and that's what it's all about so give yourself salt some magnesium you'll start feeling better patient said oh I get so hungry well hunger comes and goes there's a ghrelin increase and decrease according to the circadian cycle so all you have to do is pay attention yes I'm hungry all right drink some water expand your stomach and you'll feel better half an hour later the hunger is gone keep your mind busy get going do something have your chores get get them done your hunger will go away patients don't continue to be hungry all day long it just doesn't happen if they are craving is again like I told you they've developed a Pavlovian reflex or they've become a junkie so hunger comes hunger goes most patients find the second day the hardest and then from the third day onward they actually feel good and the third and fourth day of fasting fourth day they feel phenomenal on the fifth day they they want to go running you want to go to the gym they feel wonderful so you got to get over that hump if you really want to do that type of a fast you have to know that I'm going to face a problem on the second day is going to be hardest third fourth fifth day I'll do better so who should do the wrong fast and who should just do intermittent fasting so first and foremost if you just want to be healthy eat once a day at the most twice a day in a six to eight hour window period so that's called time-restricted feeding so if you just want general maintenance you want to lose a little bit of weight you want to stay healthy you don't want to become a diabetic you don't want diseases of modern man then start eating less frequently start learning how to eat once a day or twice a day in a six hour window period so if you're gonna have lunch at one o'clock you should have dinner at six or seven o'clock in that sit no snacking in between because every snack will increase your insulin levels and it breaks your fast and your ketogenesis as well so on a daily basis it will give you a little bit of autophagy will give you a little bit of ketosis and you'll burn fat you your body will learn how to take food in when you're eating and then burn the glycogen and then for about four hours or so it will pull out some from the fact so it will there's a nice cycle there then once a week you can extend that skipping the evening meal also so instead of a 24 hour fast it becomes a 36 hour fast once a week that will give you a huge boost in your immunity you'll find you won't get the flu your immunity will get better because your immunocytes are now new because your stem cells have kicked in 36 hours is a magic number and it's doable to tell everybody to do a three day fast is kind of tough for a five day fast but people have done this some of my patients have done seven day fasts there's some people with whom i communicate with my iphone all the time 14 day fasts but they're doing it because they have severe diseases so they have a lot of chronic disease that they want to get rid of and they do it and they're doing don't do it a lot they'll do a seven day fast every six months that's it you don't have to now the rest of the the rest of the day fasts you don't have to now the rest of the day fasts you don't have to now the rest of the the rest of the day fasts you don't have to now the rest of the day fasts you don't have to now the rest of the the rest of the day fasts you don't have to now the rest of the time they're doing time restricted time they're doing time restricted time they're doing time restricted feeding feeding feeding because they have these chronic diseases because they have these chronic diseases because they have these chronic diseases of alzheimer's or diabetes or they get of alzheimer's or diabetes or they get of alzheimer's or diabetes or they get they've had two cancers already or they they've had two cancers already or they they've had two cancers already or they want to just lose a lot of weight and want to just lose a lot of weight and want to just lose a lot of weight and they want to get rid of that high they want to get rid of that high they want to get rid of that high insulin level insulin level insulin level so so so eating eating eating in a time restricted period that's good in a time restricted period that's good in a time restricted period that's good for all of us i think that our life revolves around i think that our life revolves around i think that our life revolves around eating too much eating too much eating too much and we've been we've been bamboozled by and we've been we've been bamboozled by and we've been we've been bamboozled by by industry by industry by industry and and by just all sorts of and and by just all sorts of and and by just all sorts of nonsense out there nonsense out there nonsense out there and there's a growing community that and there's a growing community that and there's a growing community that understands this understands this understands this so i just want to give you a little bit so i just want to give you a little bit so i just want to give you a little bit of a look at how your body know of your body know of your body know that you didn't eat because all of you that you didn't eat because all of you that you didn't eat because all of you think oh it's sugar my sugar never go think oh it's sugar my sugar never go think oh it's sugar my sugar never go down that's how my body knew that i down that's how my body knew that i down that's how my body knew that i didn't eat right i did nothing to do didn't eat right i did nothing to do didn't eat right i did nothing to do that your body knows what you ate how that your body knows what you ate how that your body knows what you ate how did it know what you ate how much did it know what you ate how much did it know what you ate how much protein how much fat how much sugar how much fat how much sugar it's very complicated but one of the it's very complicated but one of the it's very complicated but one of the things is things is things is your nad which is your one of those your nad which is your one of those your nad which is your one of those little molecules inside your cells little molecules inside your cells little molecules inside your cells and it looks at the ratio of nad to nadh and it looks at the ratio of nad to nadh and it looks at the ratio of nad to nadh and that is determined a lot by how much and that is determined a lot by how much and that is determined a lot by how much fat metabolism is going on in your cell fat metabolism is going on in your cell fat metabolism is going on in your cell which occurs in the mitochondria and how which occurs in the mitochondria and how which occurs in the mitochondria and how much glycolysis is occurring in your much glycolysis is occurring in your much glycolysis is occurring in your cytosol cytosol cytosol long and short of it you don't need to long and short of it you don't need to long and short of it you don't need to know all that all you need to know know all that all you need to know know all that all you need to know is your body knows what you ate is your body knows what you ate is your body knows what you ate so so so when you are in a fasting state they when you are in a fasting state they when you are in a fasting state they mobilize a mobilize a mobilize a bunch of bunch of bunch of enzymes or proteins called the cert one enzymes or proteins called the cert one enzymes or proteins called the cert one molecules s-i-r-t-1 molecules they go up molecules s-i-r-t-1 molecules they go up molecules s-i-r-t-1 molecules they go up in your body in your body in your body in a fasting state in a fasting state in a fasting state and in that state it binds to acetyl and in that state it binds to acetyl and in that state it binds to acetyl groups groups groups now what's so important about that now what's so important about that now what's so important about that so when the cert is so when the cert is so when the cert is up it binds with acetyl groups on your up it binds with acetyl groups on your up it binds with acetyl groups on your histones which are on your dna histones which are on your dna so you all know now this is just follow so you all know now this is just follow so you all know now this is just follow me on this because this is really it's me on this because this is really it's me on this because this is really it's exciting because if you know the exciting because if you know the exciting because if you know the knowledge behind this you'll get excited knowledge behind this you'll get excited knowledge behind this you'll get excited about it about it about it and you'll want to do it so your your and you'll want to do it so your your and you'll want to do it so your your your dna your dna your dna you have your full set of dna of which you have your full set of dna of which you have your full set of dna of which you only express you only express you only express a fraction less than one percent all the a fraction less than one percent all the a fraction less than one percent all the rest of your dna is all covered up with rest of your dna is all covered up with rest of your dna is all covered up with the histones histones are like a spring the histones histones are like a spring the histones histones are like a spring that's over your dna and doesn't expose that's over your dna and doesn't expose that's over your dna and doesn't expose it it it so what the cert does it binds to the so what the cert does it binds to the so what the cert does it binds to the astral groups astral groups astral groups and it untwists histones in certain parts and it untwists histones in certain parts and it untwists histones in certain parts of your dna so that that part of the dna of your dna so that that part of the dna of your dna so that that part of the dna can start making can start making can start making proteins so it's called expression your proteins so it's called expression your proteins so it's called expression your genetic expression changes because now genetic expression changes because now genetic expression changes because now you're making new proteins so you see how you're making new proteins so you see how you're making new proteins so you see how your diet affects which your diet affects which your diet affects which genes are now going to be expressed genes are now going to be expressed genes are now going to be expressed and those genes make proteins and that's and those genes make proteins and that's and those genes make proteins and that's how they carry out the effect in your how they carry out the effect in your how they carry out the effect in your body body body so the third one actually activates a so the third one actually activates a so the third one actually activates a gene called the fox03 gene gene called the fox03 gene gene called the fox03 gene and this fox03 gene activates many and this fox03 gene activates many and this fox03 gene activates many other genes other genes other genes and this is what those genes do and it's and this is what those genes do and it's and this is what those genes do and it's very exciting very exciting very exciting it activates all the antioxidant genes it activates all the antioxidant genes it activates all the antioxidant genes in your body in your body in your body naturally naturally naturally naturally so you don't need to go and buy naturally so you don't need to go and buy naturally so you don't need to go and buy it activates fox03 also turmeric does it activates fox03 also turmeric does it activates fox03 also turmeric does that that that you think turmeric is a antioxidant you think turmeric is a antioxidant you think turmeric is a antioxidant it is but through the mechanism it is but through the mechanism it is but through the mechanism it turns on a certain gene in itself it it turns on a certain gene in itself it it turns on a certain gene in itself it has no antioxidant properties why why why am i doing vitamin three d3 why why why am i doing vitamin three d3 why why why am i doing vitamin three d3 levels on everybody in my office because levels on everybody in my office because levels on everybody in my office because one of this the most important vitamin one of this the most important vitamin one of this the most important vitamin involved with gene expression is involved with gene expression is involved with gene expression is vitamin d if you're vitamin d deficient vitamin d if you're vitamin d deficient vitamin d if you're vitamin d deficient your gene expression is handicapped your gene expression is handicapped your gene expression is handicapped so when things happen to you or when so when things happen to you or when so when things happen to you or when you're not eating or when you get sick you're not eating or when you get sick you're not eating or when you get sick your body is genetic your body is genetic your body is genetic material material material cannot reveal itself in a normal way cannot reveal itself in a normal way cannot reveal itself in a normal way that you're supposed to that you're supposed to that you're supposed to do you just want to say about vitamin d do you just want to say about vitamin d do you just want to say about vitamin d you're handicapping yourself in your own you're handicapping yourself in your own you're handicapping yourself in your own ability ability ability to repair your body because you're to repair your body because you're to repair your body because you're vitamin d deficient vitamin d deficient vitamin d deficient and i can tell you right now 90 of you and i can tell you right now 90 of you and i can tell you right now 90 of you are in this room are vitamin d deficient 90 of you are vitamin d i can i can tell 90 of you are vitamin d i can i can tell 90 of you are vitamin d i can i can tell you that for sure you that for sure you that for sure that's a all of you have to get your that's a all of you have to get your that's a all of you have to get your vitamin d levels done and you need to be vitamin d levels done and you need to be vitamin d levels done and you need to be taking vitamin d3 if you are low and taking vitamin d3 if you are low and taking vitamin d3 if you are low and you need to be sitting in the sun for 10 you need to be sitting in the sun for 10 you need to be sitting in the sun for 10 minutes every day minutes every day minutes every day you got to do this you cannot guess what you got to do this you cannot guess what you got to do this you cannot guess what your vitamin d level is you need to your vitamin d level is you need to your vitamin d level is you need to check it check it check it so vitamin d is involved in over 300 so vitamin d is involved in over 300 so vitamin d is involved in over 300 different reactions and most of them got different reactions and most of them got different reactions and most of them got to do a genetic expression heck i want to do a genetic expression heck i want to do a genetic expression heck i want to know that to know that to know that because i want to express my genes to because i want to express my genes to because i want to express my genes to the best of the ability and make them the best of the ability and make them the best of the ability and make them responsive to everything that's going on responsive to everything that's going on responsive to everything that's going on so the fox o3 gene is really important so the fox o3 gene is really important so the fox o3 gene is really important antioxidant gene antioxidant gene antioxidant gene then the next gene is dna repair then the next gene is dna repair then the next gene is dna repair so it activates my dna repair so it activates my dna repair so it activates my dna repair mechanisms because my dna is bombarded mechanisms because my dna is bombarded mechanisms because my dna is bombarded every day by radiation by toxins by every day by radiation by toxins by every day by radiation by toxins by by food also and my dna crumbles every by food also and my dna crumbles every by food also and my dna crumbles every day that's why i get old so that's no day that's why i get old so that's no day that's why i get old so that's no good so it makes you younger so fox o3 good so it makes you younger so fox o3 good so it makes you younger so fox o3 repairs your dna makes your telomeres repairs your dna makes your telomeres repairs your dna makes your telomeres less short so they stay nice and long less short so they stay nice and long less short so they stay nice and long and you know that telomeres are very and you know that telomeres are very and you know that telomeres are very important right important right important right because the longer they are the longer because the longer they are the longer because the longer they are the longer you're going to live you're going to live you're going to live apoptosis apoptosis is cell programmed apoptosis apoptosis is cell programmed apoptosis apoptosis is cell programmed death death death of the cells so it controls that of the cells so it controls that of the cells so it controls that clearance of senescent cells that's clearance of senescent cells that's clearance of senescent cells that's apop that's a apop that's a then protein structure and maintenance then protein structure and maintenance then protein structure and maintenance this is alzheimer's disease what is this is alzheimer's disease what is this is alzheimer's disease what is alzheimer's alzheimer's brain cells don't alzheimer's alzheimer's brain cells don't alzheimer's alzheimer's brain cells don't work very good why don't they work work very good why don't they work work very good why don't they work very good because there's a proteinaceous very good because there's a proteinaceous very good because there's a proteinaceous material that is built up inside it material that is built up inside it material that is built up inside it and that kind of hurts the mechanisms of and that kind of hurts the mechanisms of and that kind of hurts the mechanisms of your brain cells that's amyloid amyloid your brain cells that's amyloid amyloid your brain cells that's amyloid amyloid deposition deposition deposition this is involved with that too this is involved with that too this is involved with that too and then stem cell mobilization brain and then stem cell mobilization brain and then stem cell mobilization brain derived neurotropic factor all these derived neurotropic factor all these derived neurotropic factor all these things i already mentioned they're all things i already mentioned they're all things i already mentioned they're all through the fox o3 mechanism you want to through the fox o3 mechanism you want to through the fox o3 mechanism you want to get good fox o3 you need to have get good fox o3 you need to have get good fox o3 you need to have vitamin d in your system vitamin d in your system vitamin d in your system and you need to be eating the right food and you need to be eating the right food and you need to be eating the right food and the right food means and the right food means and the right food means no processed foods everything that was no processed foods everything that was no processed foods everything that was there two and a half million years ago there two and a half million years ago there two and a half million years ago vegetables vegetables vegetables some fruit oh by the way i want to talk some fruit oh by the way i want to talk some fruit oh by the way i want to talk about fruits overrated so what happens is that at the end of so what happens is that at the end of so what happens is that at the end of the summer the summer the summer and fall the fruit is bearing there and fall the fruit is bearing there and fall the fruit is bearing there and you're supposed to eat the fruit with and you're supposed to eat the fruit with and you're supposed to eat the fruit with all that fructose to get you through all that fructose to get you through all that fructose to get you through winter but winter never comes so you keep eating throughout the year so you keep eating throughout the year so you keep eating throughout the year so and you keep gaining the weight so so and you keep gaining the weight so so and you keep gaining the weight so fruits are good for you but you fruits are good for you but you fruits are good for you but you associate one fruit a day associate one fruit a day associate one fruit a day that's it and choose the most colorful that's it and choose the most colorful that's it and choose the most colorful fruit you can and mix it up a little bit fruit you can and mix it up a little bit fruit you can and mix it up a little bit but please don't don't eat five six but please don't don't eat five six but please don't don't eat five six fruits a day i mean that's just that's fruits a day i mean that's just that's fruits a day i mean that's just that's just crazy and eat just crazy and eat just crazy and eat fruit that have a low glycemic index fruit that have a low glycemic index fruit that have a low glycemic index high glycemic index fruits are high glycemic index fruits are high glycemic index fruits are watermelon all the melons that you have watermelon all the melons that you have watermelon all the melons that you have all the stuff that they give you when all the stuff that they give you when all the stuff that they give you when you order a fruit plate in the in the you order a fruit plate in the in the you order a fruit plate in the in the restaurant that's all that bad stuff all restaurant that's all that bad stuff all restaurant that's all that bad stuff all of it of it of it the kiwi fruit in it is bad the the the kiwi fruit in it is bad the the the kiwi fruit in it is bad the the grapes are bad grapes are bad grapes are bad uh bananas are 50 50 but the best things uh bananas are 50 50 but the best things uh bananas are 50 50 but the best things are apples peaches plums are apples peaches plums are apples peaches plums apricots those are very healthy for you apricots those are very healthy for you apricots those are very healthy for you right because a lot of fiber and also right because a lot of fiber and also right because a lot of fiber and also low glycemic index low glycemic index low glycemic index so there you go pears pears are very so there you go pears pears are very so there you go pears pears are very good good good so now what so now what so now what other agent helps you to express your other agent helps you to express your other agent helps you to express your cert one better cert one better cert one better it's omega-3 now you know why i'm so it's omega-3 now you know why i'm so it's omega-3 now you know why i'm so anal about omega-3 levels anal about omega-3 levels anal about omega-3 levels they need to be so again i can promise they need to be so again i can promise they need to be so again i can promise you not 95 90 i think 95 of you in this you not 95 90 i think 95 of you in this you not 95 90 i think 95 of you in this room are probably room are probably room are probably omega-3 deficient now it's not may omega-3 deficient now it's not may omega-3 deficient now it's not may not be an absolute deficiency but the not be an absolute deficiency but the not be an absolute deficiency but the ratio of your omega-3 to omega-6 is off ratio of your omega-3 to omega-6 is off ratio of your omega-3 to omega-6 is off it should be ideally one to one but i it should be ideally one to one but i it should be ideally one to one but i bet you most of you are about 20 to one bet you most of you are about 20 to one bet you most of you are about 20 to one because omega-6 is found in all the because omega-6 is found in all the because omega-6 is found in all the vegetable seed oils vegetable seed oils vegetable seed oils so what happens is that this ratio is so what happens is that this ratio is so what happens is that this ratio is because what happens is three and six because what happens is three and six because what happens is three and six compete for the same substrate compete for the same substrate compete for the same substrate so you can be taking fish oil fine but so you can be taking fish oil fine but so you can be taking fish oil fine but if you're also using vegetable oil if you're also using vegetable oil You've just defeated the purpose. Omega 3 also lengthens your telomeres as that's vitamin D. See simple measures, simple things. What else lengthens your telomeres and helps with your DNA is meditation. Meditation actually has been shown to increase your telomeres. And lack of sleep shortens them and melatonin. I want to say something about melatonin. Melatonin prevents cancer but it also turns on FOXO3. So if you're not getting melatonin, you're not getting sleep at night, you're not getting rejuvenation. Now you know the mechanism of why you get so old because you're only sleeping 3 hours a night or 4 hours a night. Or worse still, you're doing night shift and all those things and therefore your sleep is totally dysfunctional. But very, very important. So now you know that the body actually is very intelligent. What you eat immediately starts changing your genetic expression. Did you ever think about that? I never thought about that until I did all this research and started researching all this about 5, 6 years ago about diet. I always thought that it'll just change my hormones, my cholecystokinin, my insulin. My genetic expression changes with every meal that I eat? Yes it does. It's very empowering to know that. Don't forget it. Pass it on. So when you eat proteins, you produce a stuff called insulin-like growth factor 1. Now this is a warning to all of you. Too much protein will produce too much IGF-1, insulin-like growth factor 1. That turns on mTOR. I mentioned mTOR earlier on. And these are protein kinases. And what this does, it regulates your ribosomal production to make more protein, which is good. So when you eat protein, you make more muscles. That's fine. But you also have cell proliferation. And what that does, it increases your risk of cancer. Now there's absolutely no doubt that a high protein diet increases the risk of cancer. I think that data is unequivocal. It's been shown in animals and also in some human studies now. Does it depend on the type of source? The mTOR also decreases autophagy. So if you are on a high protein diet and you think that you're getting autophagy, you've just turned it off because of mTOR. Because I mentioned that earlier on in my talk. It turns off mTOR. So how much protein should you have? Well, not a lot. How much is not a lot? Well, you're not growing. You're not lactating. You've all passed puberty. You're not bodybuilders. 0.35 per pound. That's it. Grams per pound. So I weigh 150. So 50 grams of protein. That's all I need. And I'm going to get enough of that in my regular diet. Taking protein powder, not a good idea. Not a good idea. Cut it out. We did it. We all did it. I did it for a while. You will notice your sugar levels go up. It stimulates your insulin production as well. And it's got a lot of glucose in it. And it will cause IGF-1 levels to go up. And it increases protein synthesis, risk of cancer, and decreases autophagy. Now I'm just telling you that autophagy is so important. And here this thing turns it off. Don't do protein bars, for goodness sake. You don't need it. And nature doesn't give you protein on its own. It gives it to you in the form of meat. You want some protein? Go and eat the meat. You want some protein? Go eat the chicken or the fish. And make sure it's nice and lean and not fed on corn. Because then you'll get too much omega-6 as well. So, there you go. Now, there's a... So insulin like growth factor is just like growth hormone. So there's a group of people out there in Ecuador. And they have Laurent syndrome, which is a gene mutation. I've got to tell you about this. What that means is that they... The growth hormone receptor has a mutation. So it doesn't work very well. So these people are very short. They're real short. They're real stubby as well. But they live to be 100, 110. And they have no cancer. And no high blood pressure. And it's all to do with that growth hormone receptor mutation. That is why we're saying that, listen, if you want that type of physiology, you need to cut down on the amount of protein you need. It's overrated. Because you go to a restaurant and you order your salad. And what's the first question? Protein? No, I don't need any protein in my salad. Thank you. But they'll always ask you for that. It's overrated. I'm not saying that you shouldn't add some grilled chicken to your salad or something. You can do that. But take it in the context of how much protein you're eating during the day. And please don't supplement even more. Unless you have illness. Unless you have GI problems. And you can't otherwise eat. And you're wasting away. And your teeth are really bad. And you're sick. You might need some protein. Most of us don't need it. 99% of us don't need it. So in those patients, they have very low insulin levels. Very low insulin growth factor levels. And there you go. So you'll have less diabetes, less cancer in those patients. So different diets turn these genes on and off. When you eat sugar, you turn on a gene called RAS-PKA. It's crazy. So this is a protein kinase as well. And what does that do? Again, it turns off autophagy. It reduces the production of your insulin. And basically makes you more inflammatory. Because it turns off all those things. So you become inflammatory. Sugar causes inflammation in the body. Fructose causes insulin resistance in the liver. I went over that with you all before. So sugar is very, very bad for you. Sugar is a poison. Sugar is not natural. Sugar was never found in nature. It's a totally processed food. It's processed. It's as processed food as all the other processed foods that you eat. It's just as processed. But people think sugar is just... It's natural sugar, you know. It's sugar. No, it's not sugar. It's processed. It's totally processed. There's no such thing as sugar. It's totally processed. So if you don't want cancer, heart disease, diabetes, degenerative joint disease, inflammatory conditions of the bowels,
Speaker 6then don't get old.
Speaker 3Don't get old. Now, why did I say that? Because there's a lot of truth to what I'm going to say here, okay? So all these conditions are conditions that occur in aging. If you can slow down aging, you won't get those conditions. So what is the best way to stay young? Your genetic material, and for you to constantly stay young. But I told you already how to do that. Fasting. Keep your weight down. Eat the right foods. Your genetic material will stay young. You stay younger, you're not going to get those five conditions. If you get prematurely old, and by the way, we're getting old fast. It's 30-year-olds, and now even 20-year-olds coming into my office, and they're already 50 years old. Because of the lifestyle. What they're eating, their lifestyle, their sleep patterns, their stress patterns. So don't get old. So everything that I'm saying is also anti-aging. So now, does that mean I'm an anti-aging doctor?
Speaker 6I am.
Speaker 3But there's a lot of other people out there also doing anti-aging. But I'm a different anti-aging kind of doctor. I do it more naturally, and I know the science behind it. So I'm not going to tell you to go and, you know, take the special cream, and put it on you, and eat the special concoction, because how natural is all that? Just how natural is that? I mean, if you want to be natural, then you don't walk away from one of those providers with a bag load of drugs, and creams, and other things. I mean, how natural is that? I have nothing to sell you. I got nothing. I got vitamin D in my office. I got vitamin K2. By the way, you all should be on vitamin K2 as well. What is vitamin K2? Vitamin K2 takes the calcium, takes it out of your tissues, and puts it back into the bone where it belongs. So how come you got vitamin K2 deficiency? Because you're on that low-fat diet, right? So it's absorbed through fat. You don't have fat, you're not going to absorb vitamin K. You don't have fat, you're not going to absorb vitamin D. How do you think you all became vitamin D deficient? Because we went on this low-fat craze. Low-fat this, low-fat that. So it compounded your nutritional deficiency. When you went on a high-carb diet, which is high-carb, what the government told us to do because what we did we went on a low fat diet and substituted all with carbs you also became nutritionally a desert because you didn't get all the good things look when you eat natural fats in natural ways let's say you eat a piece of a fish or you eat meat or eating vegetables it comes with everything in it so your ADEK will get absorbed with the natural fat you need it you need it and that's how it's going to get absorbed because that's how it was two and a half million years ago who are you to try to change this in the last millisecond of your life in your evolution okay so let's talk about that how many generations were before you because that will be an eye-opener for you I have a different down here somewhere in my notes how many generations have gone by and it's a real eye-opener oh man where do I write it oh yes oh yeah here it goes so in the two and a half million years there were a hundred thousand generations and each generation improves on these genetic materials that are good a hundred thousand generations and then they produced the homeo sapien how many generations were in the agricultural time since the agricultural thing happened only 600 generations so 600 generations have been eating the the benefits of the agricultural revolution and what about the Industrial Revolution which changed it even more because remember much of the agricultural was okay actually because the grains were kind of whole but in the Industrial Revolution how many generations have gone by only 10 only 10 you have no chance of survival because your genetic material hasn't had a chance to even just only been ten generations so you drastically change the way you live you drastically change your diet and you expect ten generations to drastically change your genetic material now if you're lucky and you procreate wisely you're going to change your genetic material now if you're lucky and you procreate wisely you're going to change your genetic material now if you're lucky and you procreate wisely Then maybe another thousand generations from now your kids will adapt to this new diet. But right now you stand no chance. You see what I'm saying? Keep, stay on this diet, stay on this lifestyle, and after another thousand, maybe two thousand, three thousand generations, the new human being will have adapted to today's food. You won't stand a chance. So there you go. Alright, so how much more time do I have? I have a little bit more time, so I want to give you a few more hints over here on fasting and things to say about fasting. So, I already talked about the biochemical changes and I told you how. So the first thing you need to do, if anyone wants to start a fasting program, is to cut your diet. You need to cut down on your carbohydrates. You cannot jump into a fasting program with a regular diet. You have to first be carb-conditioned. You need to cut down on no processed foods. No processed foods. Nothing unnatural, anything that's refined, no sugar, no drinks except for water and tea and coffee. And by the way, when you're fasting you can have tea and coffee and all that, but without the milk or cream. You can add a little bit of coconut if you want, coconut oil that is. Um. Or MCT oil because that will give you some satisfaction and take away your hunger for a while. So that's very important. Um. I want to say, oh yes, I want to say this, refeeding syndrome. So let's say one of you did decide to do a three day or four day fast. I warn you that when you start eating again, you may have a problem because what will happen is that if you are phosphate deficient, because you're nutritionally already eating the standard American diet, the SAD diet, then you don't have enough phosphate in your body. And your bones are the biggest storage of phosphate and most of us have osteopenia. How come we have so much osteopenia? These 30 year old women that come to my office and say, "I have osteopenia." How come? It's terrible. Living in Florida, we all have osteopenia. It's terrible. So obviously when she does her refeeding, she's going to get phosphate deficiency because what happens all of a sudden, stem cells go in, they need building blocks. And one of the building blocks is phosphate to replace the cells that have died. So you get phosphate, so you get tremendous muscle weakness and muscle aching. And that's from phosphate deficiency and that can happen. So when that happens, you need to go and get some bone broth. So all of you should know how to make some bone broth if you've made it. I've been doing it for years. But you know, just put some bones in there and how to cook the bone broth. You should know how to make one. Now if you're a vegetarian, you can make it out of vegetables too. But it's very, very helpful. And even during a fast, if you absolutely have to do anything, you can have some bone broth. During a fast. Okay? Bone broth. Because it's got a lot of glycine in it and it's got phosphate and it's got a lot of minerals in it. And that will really help you. Even the magnesium. So it will help you overcome some of your problems. So learn about bone broth. And don't buy ready-made bone broth. Make it yourself. By the way, there's lots of recipes now on the low-carb diet, what kind of breakfast, lunch or dinner, whatever you want to cook is available. Bone broth, how to make it. My favorite book that I use is Jason Fung's book, right? Jason Fung, F-U-N-G. He's a nephrologist up in Canada. And he sees all these really heavy-duty diabetics. And he does amazing work. But you see, he's learned all these tricks to make success. So the potassium can fall. Magnesium can fall. And phosphate. So refeeding, just be careful. Use bone broth during that time. I already mentioned all the side effects, which are okay. Coffee, tea. I mentioned the tea. And black tea. Medicines. Medicines, yes. When you're doing fasting, it depends which medicine. Now, if you're taking diabetes medications, and I'm telling you all, if you're taking diabetes medications, they will cause a drop in your sugar level. And it could be a dangerous drop in your sugar level. Especially insulin should not be taken. And glyburide, glipizide, those agents should not be taken. But don't do that without your physician knowing. You've got to involve your physician. If you're a diabetic patient, your physician needs to know about it. If your physician doesn't want to know about it and doesn't approve of you doing fasting, maybe you need to find another one. You see, because, and look, it's not bad. Look, physicians are great. But we're taught to treat illness. Get sick, and I'll know what to do with you. But you want to stay healthy? Heck, I don't know. That's the problem we have. So it's not that they don't want to help you. It's just that they don't know. They've never been there to handle that kind of situation. I'll tell you what I do with my patients, okay? I stop the insulin right there. No more insulin. And I stop glyburide or any other agent that drops blood sugar except for metformin. I keep them on metformin. And then I tell them to measure their blood sugars. And for three days or two days, they may have high blood sugar. But that's not going to hurt them. That's not going to hurt them. So if you look at what hurts you the most, it's the high insulin. That's what hurts you the most. It's the high insulin level that hurts you more. If your glucose level is a little bit high, okay, that may glycate some of your proteins. But it's temporary. It's not going to hurt you in the long term. But insulin will hurt you. So that's what I've done. And for most of them, after the fast, they feel a lot better. And they can come off insulin. They should be able to come off insulin. But you've got to -- you know, the trouble with physicians is -- and myself included -- we're so busy. We're so busy. We're so busy. We're so busy. We're so busy. We're so busy. We're so busy. We're so busy. We're so busy. We're so busy. We're so busy. We're so busy. We're so busy. We're so busy. We're so busy. We're so busy. We're so busy. We're so busy. We're so busy. We're so busy. We're so busy. We're so busy. We're so busy. We're so busy. We're so busy. We're so busy. We're so busy. We're so busy. We're so busy. We've got so much to do. We've got so much to do. We've got so much to do. We've got so much to do. We've got so much to do. We've got so much to do. We've got so much to do. We've got so much to do. We've got so much to do. We've got so much to do. We've got so much to do. We've got so much to do. We've got so much to do. We've got so much to do. We've got so much to do. We've got so much to do. We've got so much to do. We've got so much to do. We've got so much to do. We've got so much to do. We've got so much to do. We've got so much to do. We've got so much to do. We've got so much to do. We've got so much to do. We've got so much to do. We've got so much to do. We've got so much to do. We've got so much to do. We've got so much to do. We've got so much to do. We've got so much to do. We've got so much to do. We've got so much to do. We've got so much to do. We've got so much to do. We've got so much to do. We've got so much to do. We've got so much to do. We've got so much to do. We've got so much to do. We've got so much to do. We've got so much to do. We've got so much to do. We've got so much to do. with the doctor that you can approach or a walk-in clinic that you can walk into that's why I have a my walk-in clinic right people can walk in and yeah the matter that might have to wait back please they're gonna be seen and if I'm tied up at least my my practitioners will take care of the patient so your blood pressure will drop because you become volume depleted or because of your physiology changing the physiology is changing that's your blood pressure is dropping so yeah it can come off look high blood pressure sugar high triglycerides and low HDL are all part of metabolic syndrome this makes metabolic syndrome better therefore your blood pressure will come down your sugar will come down your triglycerides will come down and your HDL will go up I told you all before that the lipid abnormalities that you see very few of them are primary lipid abnormalities the rest are all reflections of your glucose metabolism that has gone haywire so the most important things to look for on your lipid panel is not your LDL it's your triglycerides and HDL and the ratio of HDL to triglycerides if it's off you have a sugar problem even though your sugar is good or your hemoglobin a1c is good if your triglycerides are high and your HDL are low and the ratio is greater than two you probably have high insulin levels and that needs to be determined and the treatment of high insulin levels today is faster changing your diet and doing intermittent now what do I do six months down the patient comes to me says oh I've lost all this weight look I feel great now I'm down on my medications I'm hardly taking anything now I will repeat his insulin levels if they are good I'll say you know what things are much better now you don't have to be so crazy about your diet anymore but automatically most of them still do time-restricted feeding because they love it they feel so good doing it so there if you go back to eating five days or five times a day you know so there you go so very important that we do this I wanted to mention something else too yes so the you know studies are very hard in humans but I wanted to show you one study that was done in monkeys about fasting so they took the monkeys the rhesus monkeys which we very closely related to them they deserve more respect I think rhesus monkeys so they took the experimental group gave them 30% less calories the standard teaching for for weight loss 30% less calories right so 30% less calories and the control group they gave them milk protein corn oil sugar and unlimited feeding times pretty much like an American diet that was the control group and then what they did is they looked at the outcome at five years in these rhesus monkeys there was 20% those who had restricted calories the 30% restricted calories they lived 26% more than the control group 50% less cardiovascular disease and greater than 90% no diabetes just by cutting calories down our food is so full of calories the more calories you eat the more disease you're gonna get there's absolutely no doubt so now the NIH they don't want to be outdone so they did a study they also did 30% caloric restriction but in the control group now watch what they did in the control group they gave them plant proteins no animal protein except for a little bit of fish five percent fat only so they gave him some fat four percent sugar in the diet and they were only fed twice a day and what did they find what do you think did they did that did those monkeys do better than the 30% caloric restriction or what do you think it was as good as the caloric restriction they didn't better yeah so so again it's your diet so just simply cutting down on 30% calories is not the way to go it's no longer calories in calories out it's how your body reacts to the calories and what calories go in it's your hormonal response how you respond hormonally and how you respond through your genetic expression so be careful what goes past the tongue because that's going to determine your future and you know I always like questions and answers so I'm going to stop right there but today's main message is if you want to do a serious fast talk to somebody who knows a lot about fasting do it with somebody talk to your doctor if you're on diabetes medications or blood pressure medications if you want to simply replicate the paleolithic way eat once a day or twice a day only do it in a time-restricted fashion all of you can do it all of you you don't need medical permission to do that the only time I'm telling you to seek more help is if you want to do a three-day five-day or seven-day water fast or even more water fast all right and there's a lot of books that you all can read especially Jason fung's book and and if there any other questions by the way as I said before this talk I'll put my slides in there and then post it onto YouTube Galen foundation wants to continue doing stuff like this so my next one I'm going to talk about all sorts of things including sleep I'm going to a whole topic on sleep and how to improve your sleep that's so important so I want to do that but you know Galen needs help as usual so any help you all can give Galen foundation as well it's a 501 3c and if you know people who would like to help this type of organization ask them to help us out as well and of course they can come to our talks and our websites as well
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