3. Benzodiazepine

[Music] Psychoactive, your drug and alcohol podcast with Steffi, pull yourself together. [Music] Guys, welcome to the second Substance Sunday. Today it's really about a substance. It's really great that you're back with us. And today we'll start with the topic of benzodiazepine. It's a bit strange that I'm starting with benzos. But that's because I've just read a lot about benzos for the work I've done. That was a request from one of my clients. And then I thought it would be a bit of an efficient thing to bring in the whole thing, because I already have a lot to do with work and study. I'll also make the first Substance Sunday episode about benzos when I just got in there. And that's how you come to the Benzo episode. Before we start with the topic, it's really important to me to say that the Substance Sunday episodes are there to make informed decisions for yourself. And after the credo, I research with the best knowledge and knowledge about different substances. The Substance Sunday episodes are to introduce an instruction for consumption or motivate people for consumption. If you notice that your consumption is somewhere in the skirmish, seek help, seek support, talk to others about it. Either in the sexual counseling or in the social environment, whom you can trust best. But please don't stay alone with your concerns. That's important to me to say. Alright, let's start with the topic. Benzodiazepines or short benzos. And I'll stay with the word benzos, otherwise I'll be proud of the word benzodiazepines all the time. So benzos are used in the medical field for acute treatment for anxiety, panic disorder and epilepsy and have both physical and psychological symptoms. What does that mean? On the psychical level, Benzos seem to be afraid of sleep disorders or aggression, so calm and in the physical effect it seems to be caused by a muscle tension. So it can also be used in epilepsy. How does the effect of benzos look like in our body now? I'll explain it again in detail on behalf of the metaphor I explained two weeks ago on the Substance Sunday. If you haven't seen this episode yet, you might want to follow it, because I don't think the metaphor is very comprehensive, if you haven't given yourself to it. So just one episode back, even two next. And that's how the episodes look like in our brain. In principle, benzos have two effects. On the one hand, they ensure that our neurotransmitter GABA has been excreted more, GABA, if you still remember, is, so to speak, our scapula for the brain, so it has a calming and relaxed effect on us. In addition, benzos bind to the GABA receptors and ensure that when the neurotransmitter GABA is applied, the action that is continued is strengthened. GABA receptors are found everywhere in our body and in the brain, in the peripheral organs and in the back. Let's get to the metaphor. We have learned in the last Substance Sunday episode that drugs can work on our brain in seven different ways. With benzos, it is so that they both belong to the excretion dictators as well as to the undercover agents. What this means? The benzoan follower sets himself at the starting point, so the presynopsis, and ensures that one fat fleet is sent to GABA. This then breaks into the brain. The brain was the synapsic split to then set itself at the starting point, to the receptors at their target of the post-synapse. Meanwhile, however, all the small undercover boats are on their way to the starting point and have brought the language experts, in principle, the Prölen, with them. That means that when the GABA fleet arrives, the language expert at the starting point simply continues the command. And so, the GABA fleet can bring their boats much more efficiently and effectively. Once again in terms of language, GABA is taken out, and at the same time increases the effect of GABA receptors when GABA binds to the receptors. Then the potential for action is increased. We have a greater relaxation. Let's get to the big ones from Benzodiazepines. At the beginning, in the medical field, Benzots are actually very well distributed and do not have so many side effects. But that changes over the duration of the entry, and we are talking about two phases of the side effects. The first phase of the side effects is the effect conversion. So to speak, the effect is converted, which it is actually supposed to produce. And there are the typical side effects. An restless feeling, sleep disorders, mood swings, body mismatches and an over-expansion. The second phase of the side effects is called the apathy phase. This occurs when you take Benzodiazepines over a slightly longer period of time. And the thing with Benzots is that the body builds up a mirror. That means you always need more Benzots to create the same effect. So it comes to a very fast physical tolerance development. And this ensures that you get into this apathy phase. And the symptoms for this are quite severe. This can lead to disorders in the memory and concentration. It can lead to a decrease in body energy. So you feel weak and weak. And also to an emotional, low participation. So you can no longer connect emotionally with your surroundings as you could before. And above all, in the physical field, Benzodiazepines are a kind of challenge for animals and animals and can also lead to remaining disorders. What is super important is that under the influence of Benzodiazepines you should not drive a car. Because it also comes to a very low reaction ability. I just said that it also comes to a second sleep and that's why under the influence of Benzodiazepines you should not drive a car at all. So as you already know, there are a lot of side effects. Benzodiazepines are really not without, especially with longer consumption. And that's why in the medical field the 4K rule is also recommended for writing. For what is the 4K rule? Once for a specific diagnosis. So Benzots should not be suspected, it should be a specific diagnosis. It should be the smallest dose as much as possible. It should be used for a short period of time, between 2-4 weeks. And it should not be approved. So do not postpone it. So that we have the 4K rule. I would like to go a little bit more into this not approved postponing. It is super important that Benzodiazepines, especially after a longer consumption, do not get cold. Because there can be really severe withdrawal symptoms that can sometimes even be fatal. That's why the withdrawal of Benzodiazepines should either be done by the stationary or ambulance with medical accompaniment and to dilute the medication. So the dose is always to be minimized until you are at zero. And in the stationary area, the dose is between 3-5 weeks. And in the ambulance area, even 2-4 months. So here is the proof again if you want to consume Benzodiazepines for a longer period of time and want to get out of it, contact your doctor to dilute the medication and prevent it from getting cold. After the withdrawal of Benzots, there can be a rebound symptom. What is a rebound symptom? It means that after the withdrawal of Benzots, you feel worse than the initial situation at all. That means that when I felt sick, when I got Benzots prescribed, I feel even worse than when I put it off. That sounds a bit paradoxical because you then ask yourself why should you prescribe someone a Benzots at all? What brings a short-term solution for the feelings, for the emotions? If you are actually only worse after that, the reason is that as soon as the rebound symptom is overcome, you get up again and then you feel from your anxiety that it is better than in the initial situation and in the best case, if the medication has worked really well, you are even in the normal area of anxiety. So, in principle, if you do it first, you feel much better, and after the recovery of the rebound symptom, you should be at a higher level, a more pleasant level of the feelings. Let's continue with the topic of mixed consumption. Many drugs that apply to the GABA receptors have increased risk for overdosing. This is because the hemorrhage can also cause vital functions, such as breathing, and you can fall into a coma and, in the worst case, also die. With benzos, however, it is a bit different because the reality of benzos is not that the normal level of GABA can simply exceed GABA in the body. That means that the brain still maintains its function to further regulate the GABA excretion, even though they are under the influence of benzos. But, despite all, with a very high dose, you can reduce the intake of benzodiazepine. The mixed consumption of benzodiazepine with other sedatives that also apply to GABA receptors is particularly dangerous. For example, they cause barbiturates. Unfortunately, I can't tell you much about that yet. It will probably also happen in a substance sequence, but also very important, alcohol. This mixed consumption is very difficult because it can lead to vital functions and also in opiates, a substance that bears the risk of a type depression, can present a deadly combination in this combination. Because, when it comes to a type inflammation, it comes naturally to a oxygen failure which can cause permanent damage or lead to coma or, in the worst case, death. In addition, it is important that even if benzos is a medical product and is used in medicine, it does not mean that it is not purified in the black market. If you look at the drug-checking sites in Switzerland there are often fake or purified pills in the environment and they have fallen off. So, because it is not in safety only because it is used in medicine, it can be that it is purified in the black market. Advertisement Good news, where we are at the risks, I would like to address the topic of dependency. Benzodiazepines are very well known that they are both physically and mentally dependent. Physically, as I said before, benzodiazepines have a very fast tolerance formation because the body builds itself in a mirror and in order to maintain the effect especially in a longer consumption the dose must be stalled. Therefore, the very, very fast physical dependency comes. But also mentally, benzodiazepines are very dependent. And I can also imagine that very well. I wanted to tell my little swing from my life and in the beginning of this year I was lasered. So my eyes were lasered. And I also got benzos before the operation. And I was nervous before the operation. I also find general operations very scary as fuck. So, then I got these benzos in my excitement. I beat them and I was so chilled out. I didn't want to do that at all. And when I imagine someone discovering benzos to regulate his feelings in everyday life it's very effective and also unaccountable. I wasn't as wide as before the operation but I was really relaxed a little bit at the same time and I didn't have to worry at all. You can't really deal with your emotions and your feelings and you just had this experience "Oh, if I take benzos then nobody will notice that and I don't have to deal with my emotions and feelings at the same time." And accordingly, when you look at how the dependencies are distributed in Germany I've also described what happens most often and it's called a low dose dependency. This means that the dose of the benzos is in a therapeutic area so a dose that could be prescribed by a doctor but much, much longer than normally benzo-diazipine is consumed. And this is also when there is dependency on benzo which is widely spread in Germany. Another possibility is the high dose dependency and these are people who are extremely physical and mentally dependent on benzos and the identification is exactly this that they always increase the dose because they want to have the feeling from the beginning again and that's where it comes to a similar personality change. With both dependencies what I've said before it can still be difficult to come into symptoms when you are treated medically. Last but not least I'd like to point out that benzo-diazipines are not exactly benzo-diazipines. There are various ingredients within the benzo-diazipine group that all work a bit differently. Which in Germany is most commonly used in benzos, for example albrazolam also known under the name Xennex or lorazepan also known under the name Tavor bromazepan and lexotanil and oxazepan also known under the name Andumpran. These are all medium-long, effective benzo-diazipines that means they work from 6 to 15-20 hours each a bit different and also the oral dose the daily dose is different for example in the medical area Xennex is an oral daily dose and oxazepan in the medical area is an oral daily dose of 10 to 60 mg. Let's take a look at the two benzos Flunitratzepan also known under the name Rohypnole or diazepan better known under the name Valium. This one is interesting Rohypnole is medium-long, effective between 18 and 36 hours and diazepan is effective between 20 and 100 hours and a long effective benzo but what is very important is that they work up to 200 hours in the body and how it works and that is with Flunitratzepan and diazepan when they are stopped in the body an active abutment product comes out that means this abutment product is still active in the body and that can work up to 200 hours that is totally important because of the side effects of the bad reaction in the body and that is why you can't drive a car that can work up to 200 hours with this active abutment product That was it from me and my opinion on benzo diazepan I hope you liked it if you have questions or ideas for the format please find me on instagram under psychoaktiv.podcast or you can write me an e-mail under psychoaktiv.podcast at gmail.com We will be back in two weeks until the next substance Sunday Until then I wish you a wonderful time Until then I look forward to it Bye [Music] That was psychoaktiv Your drug and alcohol podcast with steffi [Music]