A Comprehensive Guide to Cerebrolysin: Uses, Benefits, and Dosages | Cognitive Enhancement
16m 11s
This video provides an educational overview of Cerebrolysin, a peptide derived from pig brain tissue, used for cognitive enhancement and neurodegenerative conditions like Alzheimer's and stroke recovery. It explains that Cerebrolysin mimics natural neurotrophic factors, promoting neuronal growth, synaptic plasticity, and reducing brain inflammation. The presenter notes its historical use in Eastern Europe and potential benefits for traumatic brain injury and cognitive optimization, while cautioning that it is experimental and subject to regulatory scrutiny. Side effects are generally mild, such as headaches or injection site reactions. Dosage recommendations vary by condition, typically involving subcutaneous injections in cycles, and stacking with other peptides like BPC-157 is suggested for synergistic effects. The video concludes by advising viewers to prioritize hormone optimization (e.g., testosterone levels) before using nootropics, as hormonal imbalances often underlie cognitive symptoms like brain fog.
(upbeat music) - Hey everybody, this is Hunter Williams. I hope you were doing amazing wherever you are at in the world. Today's video is going to be a comprehensive guide to research with Sirreber Lyason. So this is a peptide that is very cutting edge and I will have to tread lightly with this one because the BTB don't like this one per se, but it's a very, very powerful peptide. And what I'm going to do today is just walk you through the origins, the mechanisms of Sirreber Lyason when it works in the body, the central side effects that you may experience and then anecdotal dosage reports from people that I may have heard of or come across on the internet and then we're also just going to talk about different peptides that you can stack it with to improve cognitive function. So Sirreber Lyason is an amazing research peptide that helps with cognitive function and it has been known and demonstrated to help with a lot of the neuro-degenerative diseases that are out there. So as someone who personally in my life has witnessed first-hand the effects of neuro-degenerative disease including something like Alzheimer's, my grandmother recently passed away from that. So today I want to explain how you could potentially use Sirreber Lyason for those cases, but then also just for, in general, if you're looking to improve cognitive function, I think as we are all on this journey of biohacking and anti-aging and longevity and all that stuff, cognitive health is very important. And so today I want to talk about how we can use Sirreber Lyason to help improve that because me, myself, as you probably know, if you watch my videos, I played football for 16 or 17 years, I can't remember because I hadn't hit in head too much, but all jokes aside, that's something that I'm very concerned about too and was one of the impotences for me to start this journey on the health optimization bandwagon and trained. So before I jump into that, as always, remember sign up for the peptide cheat sheet and that'll sign you up for my email list, just to make sure you stay in touch with me because when I talk about subjects like Sirreber Lyason, again, I have to tread very lightly on what I say. So everything I say in this is strictly anecdotal and hypothetical. I am not telling you to go use Sirreber Lyason. I'm not telling you where to buy Sirreber Lyason or anything like that. This is just for your education and entertainment purposes only in strictly for those. So without further ado, what I'm going to do is share my screen and today we're going to talk about Sirreber Lyason. All right, so this is going to be a comprehensive research guide to Sirreber Lyason. So my intent with this video is to enlighten you and educate you on Sirreber Lyason. So by the end of this video, you can go teach someone else and have everything you need to know to get started with your own research. So where did it come from? It was originally developed in Austria in 1949. It was derived from porcine brain tissue. So as with desiccated thyroid that I talk about comes from pigs or porcine glands, very similar to Sirreber Lyason. The reason is I don't know the exact details behind that but basically their structure, a lot of different organs within the body is very similar to human structure. So that's where it's come from. As with some people freak out about that when they hear that but I mean we eat pigs, we eat cows. We use their glands for certain things. We use like bovine different supplements to get health benefits. So it makes sense especially when you look at the, you know, how close we are to them in terms of like some of the organs and how those, you know, similar organs work in our body. So it contains lower molecular weight peptides and free amino acids. It was classified as a vital and essential medicine in Russia in 1992. As you can see, there's a lot of similar themes here with peptides in Russia. It's been used widely in Eastern Europe and Asia and it's been approved for rare conditions under orphaned drugs, status in some regions. Historically it was researched for its effect on neurodegeneration and brain injuries like incussions, TBI, that type of stuff. And it was originally studied for the neuroprotective properties to the brain. Then it was commercialized for its therapeutic potentials in neurology and it is also known by FPS 1070 and Renaissance but probably you will hear it prefer to as to re-realize it. So how does it work in the body? So basically it mimics endogenous neurotrophic factors like NGF and BDNF. Now as I say a lot in my videos when I talk about cognitive enhancing things, BDNF is brain derived neurotrophic factor which is like miracle growth of the brain. So it basically promotes neuronal growth survival in differentiation. It enhances synaptic connectivity and plasticity which just basically means that the synapses that fire and wire in the brain are going to be better connected and be more plastic meaning they're able to grow and learn new things and be able to memorize stuff at a better level. So as we age obviously that's one of the functions that declines so it's something we want to work on. It also reduces neuronal apoptosis and supports neuronal integrity. When we talk about neuronal apoptosis that just means the killing off of cells that are no longer useful, the senescent cells and supports the integrity of the neurons which basically like the cell membrane wall. So it facilitates neuroprotective effects by strengthening neural pathways, again which helps us with all those cognitive functions. It increases level of brain derived in a terrific factor in other growth factors like I said. It affects glutamate or glutamaturgic and signaling and in MDMA receptor activity. It also regulates neurotransmission and supports neurogenic repair. And it also crosses the blood brain barrier to act directly with the central nervous system and research has shown modulation of amyloid beta production relevant in Alzheimer's disease. So for what we know about Alzheimer's or dementia or whatever is basically like type three diabetes of brain, but there are these things called amyloid beta plaques that build up in the brain that we think cause inflammation. That's my understanding. Don't quote me on that. But it's going to help modulate that and reduce the inflammation that is coming from the build up of those. So what are some of the benefits? So it enhances cognitive function and dimension in Alzheimer's patients and it's been shown to do so. And also supports recovery from acute neurological events like stroke and traumatic brain injury. So now it's helpful for people that have neurodegenerative disease. But if you have some sort of traumatic event that happens to the brain like in cushion, you play sports or you're in a car accident or something like that, it's been shown to help with those as well. It also demonstrates improvement in neuropsychiatric symptoms associated with dementia. It's been shown to improve motor and cognitive recovery post stroke. So a lot of people that have strokes because blood supply is cut off from the brain. It's been shown to help regrow areas in the brain that suffer from stroke. It offers potential protective effects and Parkinson's disease, which again is kind of overlooked. But it does also in neurodegenerative disease. I think it's just a different look because of the prevalence of Alzheimer's and dementia now. It also improves outcoming conditions like cerebral palsy and traumatic brain injury. May reduce symptoms and delay progression in these neurodegenerative diseases. So a lot of people now are worried about because there's always DNA and genetic testing and people will get these done. And it says like, oh, you want to make sure that you are doing everything you can because you're predisposed to have Alzheimer's, predisposed to have dementia. So this could be something I'm not going to get into whether you should focus on that and worry about that. But if that's something that you feel like is on the cusp or feel like maybe down the future for you, you could definitely use this to potentially stymatide against that. It's also used experimentally for cognitive enhancement and learning improvement. So if you are a biohacker like myself and you just want to do everything you can to optimize the brain function and increase your intelligence and ability to think and read and process and memorize and do things can be useful in that sense. So it's also been found to be beneficial in reducing pain and chronic migraine through animal studies. So a lot of times we have inflammation in the brain that could be a cause of migraine. Migraines are a very complex subject, but that's something that it definitely could be beneficial. And research indicates it may delay the onset of Alzheimer's disease reducing overall disease burden. So you look at Alzheimer's disease, everything it does to tax the body with the inflammation that's going on and can help with that. So when you think of cerebral lice and think of all this stuff, basically just like miracle growth for your brain. Now let's look at potentially some side effects. So generally speaking is my own research and everything you can find on the internet is pretty well tolerated. And some people can cause headaches, disease, and nausea, which is kind of just like standard run of the mill side effects for most peptides. There is the potential for hyperactivity and increased body temperature. And obviously there's a risk of allergic reactions to all peptides and you can get the typical itching redness or a little bit of swelling of the injection site, which is very common. You should not worry about that. Obviously monitor it and make sure it didn't turn into infection or big bruises or anything like that. But again, this is one of those things. It came from Russia. There's not a lot of documented research on it. Nor is there a lot of vested interest I'll say in pursuing that because it is a peptide. And again, not really able to be patented as far as I understand. So obviously you're going to have regulatory advisories, causing it against the use outside of controlled research settings. So as with all peptides, it's experimental in nature. So just be careful with it. So what is the dosage? So I have this on here because I get asked this all the time about people that are using this. So dosage is obviously very widely. It's commonly administered intravenously subcure intra musculine. Now obviously if you're researching this yourself, do not do IV intravenous injections, that's going to be a clinical setting. But luckily for us, it's very common to administer subcure intravenous injections. So dosage regimens typically range from 5 ml to 10 ml. Now you notice I said ml and not mg. Typically when you purchase a re-police and if you're purchasing it research, it does not come in a milligram vial that you would mix up. It comes in an ml vial. And when you do that, it's typically a 5 ml vial. Some are 10 ml vials. So that's usually going to be one dosage. And those typically you're going to come in ampels that you pop the top off of. So what you want to do is you pop the top of that and then load that in syringe. You do have to be careful about doing that. You just want to make sure you don't break glass. So just be careful and make sure. But if you're using it, that's typically the method that you would use it. So what I did is actually if you go on the main website of cerebralisone, I actually just took this. So credit goes to there's that source right there at thecerebralisone.com. This is their dosage recommendation. So for stroke, we're looking at a daily dosage of 20 to 50 ml as soon as possible. And the duration of treatment is 10 to 21 days. The next is traumatic brain injury or concussions. We're also looking at 20 to 50 ml per day. And that's going to be as soon as possible within the injury. Typically, you're looking at 7 to 30 days before you're going to see symptom resolution if it's working. Then cognition problems. There's a little bit lower on the dosage. Honestly, I would recommend starting with 5 ml. But you'd go 10 to 30 ml as soon as possible. And the cycle for that is one cycle. And you do that five days weekly. And then do that for four weeks. So again, one cycle if you're just looking for cognitive enhancement, you're going to do five days a week for four weeks. And then you're going to do that two to four times per year. So what I would do is choose two months out of the year. To start with, you can go out, you can afford it. If it's not cost-per-havit, you can go up to four cycles per year, so just do it quarterly. And so again, that's just 5 to 10 ml. You can go up to 30 ml. But I think you're really going to see a benefit in my experience around 5 to 10 ml. 5 days a week for four weeks and do that two to four times per year. And then it's actually similar for Alzheimer's disease. Kind of depends on where you're at in the state of disease. As I mentioned, that was something my grandmother experienced. And towards the end, I don't think this would have been anything that was going to help because it was so sure, so far gone. But again, 10 to 30 ml, one cycle five days a week for weeks, two to four cycles per year. So this is the exact same thing as cognition. Again, you can check out that link. It's surrealising.com. And they have dosing information on there. So now, what are these stacks? Everyone's favorite thing is about the stacks of what to use with cerebralisone. So this is what I personally would do. Obviously, there's lots of different things out there that you can use. But basically, I would definitely pair it with BPC 157. One thing I've talked about that I don't know anyone else has really brought up is how neuroprotective BPC 157 is. My experience is someone that has experienced a lot of incustions in my life. It's been a huge, that's been a huge windfall of using BPC 157 that I wasn't expecting for years. But it hits its healing and neuronal work. Covering potentially synergising with cerebralis. Seribularlyocens neuroprotective effects. Also, TV 500, usually over the looked when it comes to brain health, but it promotes tissue repair and reduces inflammation, which is also going to help work synergistically with cerebralisone. And then we just have CMACs and salinescts. So those are the two biggest, you know, and neutrophic peptides. So CMACs are going to boost cognitive function and BDNF ovals, which is going to complement cerebralisone and work synergistically. And then salinect is going to offer angiallytic properties that can optimize the neurological environment for cerebralisone's actions. So those two should work well with cerebralisone, especially for-- you're not using necessarily for disease intervention, but just something that you're looking to improve in an optimized brain function. So that is it for the slides. And that's going to be everything you should know if you are looking to research for cerebralisone. So hopefully that was helpful to you guys. At the end of the day, cerebralisone's very powerful. I always caveat the neutrophic peptides with the following. If you are looking to improve brain function and you are not doing hormone optimization, at least getting your hormones checked and looking at your blood work, looking at all those things, I would highly recommend doing so. In my experience, you know, depression, anxiety, brain fog, all those things. I would say like 95% to 100% of those in my life resolved when I optimized my hormones because of what testosterone and a bunch of other hormones that you could look into do for the body. So primarily for men, testosterone, but for women, testosterone, estrogen, progesterone. So before we're reaching for this cerebralisone, I always say, look at your hormones first. Because if you have a total testosterone as a man of 95, that's your total testosterone, I don't know that cerebralisone's going to help you feel better. And I think a lot of times when it comes to the Neutropic peptides, things like one thing I see time and time again, is people grabbing these neutropics when it is a hormone deficiency that they're dealing with. And then once they fix the hormone deficiency, a lot of the brain fog subsides, and then you can bring in the Neutropic and just really optimize function to where you're maximizing your intelligence and energy and mental, you know, overall wellbeing. So I will say that now that doesn't mean you can't use cerebralisone if you're not using hormones, but I would just say always check that first 'cause it's usually the first line defense against a lot of the things that people typically reach for the Neutropic for. So that's all I have for today guys. If I missed anything or if you have questions, comments, I apologize because I have not been able to really get to the comments in the last couple weeks 'cause there's been so many, which is amazing, but at the same time, I just want you to know, I still see the comments. And my goal is to take all the comments if you have questions or something that I missed in the video, and then I will just film to an A video. So I'm in the process of working on that right now. So definitely, you know, just because I don't respond to the comment, know that I probably saw it. And I'm working to address that and include it in the Q&A videos for you guys to be helpful, but right now the volume is just too much and I can't respond to each one like I used to. Which is a good thing, but just know that it is helpful when you leave comments, especially the stuff like this is very complex and you have a lot of questions around it. The more I see, you know, like in the comments and questions and stuff, the more it helps make me better because I can kind of educate and teach in a way that helps speak to you guys more because we're all at different stages of the journey. And what I always try to do is put myself in your shoes to be able to teach better. So again, thank you guys so much if you stayed for all the way to the end. I appreciate you guys. Thank you so much for the support. And as always, you know, all the links are down in the description. And I will talk to you guys next time. Peace. (dramatic music)
Podcast Summary
Key Points:
Cerebrolysin is a peptide derived from porcine brain tissue, historically used in Eastern Europe and Asia for neurodegenerative conditions.
It works by mimicking neurotrophic factors like BDNF, promoting neuronal growth, synaptic plasticity, and reducing inflammation, with potential benefits for Alzheimer's, stroke, TBI, and cognitive enhancement.
Reported side effects are generally mild (e.g., headaches, nausea) but it remains an experimental substance with regulatory cautions.
Dosage varies by purpose (e.g., 5-50 ml daily), typically administered subcutaneously in cycles, and it can be stacked with peptides like BPC-157 or Semax for synergistic effects.
The presenter emphasizes checking hormone levels (e.g., testosterone) as a foundational step before considering nootropic peptides for cognitive issues.
Summary:
This video provides an educational overview of Cerebrolysin, a peptide derived from pig brain tissue, used for cognitive enhancement and neurodegenerative conditions like Alzheimer's and stroke recovery. It explains that Cerebrolysin mimics natural neurotrophic factors, promoting neuronal growth, synaptic plasticity, and reducing brain inflammation. The presenter notes its historical use in Eastern Europe and potential benefits for traumatic brain injury and cognitive optimization, while cautioning that it is experimental and subject to regulatory scrutiny.
Side effects are generally mild, such as headaches or injection site reactions. Dosage recommendations vary by condition, typically involving subcutaneous injections in cycles, and stacking with other peptides like BPC-157 is suggested for synergistic effects. , testosterone levels) before using nootropics, as hormonal imbalances often underlie cognitive symptoms like brain fog.
FAQs
Cerebrolysin is a peptide that enhances cognitive function and has neuroprotective properties. It is known to help with neurodegenerative diseases like Alzheimer's, support recovery from brain injuries, and improve cognitive enhancement in healthy individuals.
It mimics endogenous neurotrophic factors such as BDNF, promoting neuronal growth and survival. It enhances synaptic connectivity, reduces neuronal apoptosis, and crosses the blood-brain barrier to act directly on the central nervous system.
Common side effects may include headaches, dizziness, and nausea. There is also a risk of allergic reactions, with possible itching or swelling at the injection site, and potential for hyperactivity or increased body temperature.
For cognitive enhancement, a typical dosage is 5-10 ml administered subcutaneously, five days a week for four weeks. This cycle can be repeated 2-4 times per year, depending on individual needs and goals.
Yes, it can be stacked with peptides like BPC-157 for neuroprotection, TB-500 for tissue repair, and CJC-1295 with Ipamorelin or Selank for cognitive and anxiolytic benefits to synergistically enhance brain function.
Before using Cerebrolysin, it is recommended to check hormone levels (e.g., testosterone, estrogen) as deficiencies can cause brain fog. Optimizing hormones first may resolve cognitive issues, making peptides more effective for further enhancement.
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