#968: Live Q&A - Autoimmune Thyroid, MTHFR & Toxic-Free Living

Hello, welcome to the health revival show in our new temporary digs This is temporary home. Yeah, we have definitely a makeshift a situation here, but it worked out Thanks to my husband who's a genius and I don't know I can't see myself. I don't know what's going on But we're here. We're doing it if you guys are live with us on YouTube say hello Pop a comment. Let us know how your day is going where you from Are you new to the health revival show? If you are welcome. We are podcasting every Tuesday almost every Tuesday Live at 12 central answering your questions. So if you don't follow us on You know Instagram that's mainly our most active platform I would say right now for now In terms of getting myself forgetting Becca and messages That's where you can go and submit your questions if you do have questions as we're live We're gonna save some time to answer them as well But that would be where you can go and submit and what we are gonna go through today Four or five different questions and we will give you a shout out so that you know that we're answering Your question in fact. Yes, I'm excited. We I love the Q&As because there a lot of times It's hard to explain a more complex topic on a story in like 60 seconds And so we try to pick Questions that we can dive a little bit deeper, but maybe don't need like a full podcast per say And then we can hammer them out. We're actually answering questions. We know the listener you want to hear And then we usually post our Q&As I will post usually my link to the Q&A session or episode on my social media saying I answered a number of questions from the question box here So yeah, we we like the Q&As. I think they're because sometimes it's hard to come up with ideas We have done so many podcasts at this point You start to feel like you do the same ones over and over again Yeah, I would say at least from the feedback we've gotten we do a good job of Bringing things back fresh, right? Like one of the things we'll talk about today is age priori And I was like I actually don't think that we do deep into the virulence factors, which we'll get to today So but yes three podcasts a week for the past six years. We're almost gonna be in a thousand episodes soon We probably covered every topic under the sun Twice and back around but you know then again things have changed right like as new research Comes to light as people are struggling in the past few years. We've even seen more Shifts in terms of environmental factors playing a role different viruses that have emerged that are playing a role And there's just so much to cover and it's all interconnected right because the body is very complex though Yes, so let's dive in question number one is from @missylobspix l-u-v Love I'm not sure what you mean by missy loves picks, but hopefully Hopefully you use a photography for it I was thinking photographer That would make the most sense right um So she's diagnosed with graves, which is essentially an autoimmune of the thyroid that Makes the thyroid overproduced thyroid hormone, whereas Hashimoto's is the opposite More people tend to have Hashimoto's graves is a little bit more rare It's very damaging to the thyroid it can also be very dangerous graves can be a lot more life-threatening if you do not get it under control Um, whereas Hashimoto's is one of the most common forms of hypothyroidism not saying it's not a problem, but Graves is a lot more uncommon and she took methamisol Methymazol I even looked out how to pronounce I know I would see methamisol all the time But sometimes I have no idea how to pronounce these and medications I just wonder who comes up with them like what are you doing in the lab? They're like this sounds like a good name methamisol um, and it's essentially so methamisol blocks the thyroid's ability to make hormones By inhibiting the enzyme thyroid peroxidase, which is needed to convert iodine into active thyroid T3 and T4 so in the case of grazed disease where antibodies are overstimulating the thyroid But thymazol doesn't stop the immune attack It doesn't stop the autoimmune aspect. It just slows down hormone production So a lot of people with graves tend to have rapid heart rate, anxiety, weight loss So it essentially suppresses those symptoms But what she's saying is that she took methamisol now she has Hashimoto's and Graves Why? Good question Very common progression almost always I will see Graves disease ultimately turn into hypothyroidism or Hashimoto's because they are actually the same autoimmune process So they are just being expressed slightly differently Both are autoimmune thyroid diseases The immune system is attacking the thyroid in both cases The difference is how the antibodies behave so in grazed disease you have TSI antibodies That pushes the thyroid into a hyperstate. It's more stimulating right? Whereas Hashimoto's You have more destructive antibodies the TPO and thyroid glabulin They break down the thyroid right so it's not two separate things necessarily It's just a change in how the immune system is attacking and expressing things So why does it happen right? Well Graves exhausts your thyroid Like it essentially is going to burn out the level of the thyroid production over time You can't just hyper you can't push your pedal on the gas or push your foot on the gas pedal 120 miles an hour for end on end on end So hypothyroidism will develop over time. I would almost liken this to adrenal health right? So in terms of cortisol we think of High cortisol because your body is responding to something the problem is In this state of the world that we live in today. It never Is a focus in terms of like how we regulate and so over time Whatever you want to call this adrenal insufficiency adrenal burnout adrenal exhaustion There's a lot of ways but we will see on lab testing especially for somebody who's been chronically stressed for years and years and years You eventually don't have Much metabolized cortisol right? And so that's the thing that we are I'm just thinking This is what's coming to my mind if you've not heard this analogy before from the gas pedal to like the brakes That's really kind of what's happening like you run out of fuel over time And so your immune system it's the same thing like we see for people with low white blood cell count This chronic immune activation that's exhausting you're now never getting sick or you're sick all the time Like you're not mounting a appropriate response and then coming back to homeostasis And so you kind of shift from this over exhaustion to the breakdown right? And so you're destroying tissues in the body and that ultimately will Destroy the thyroid tissue and that really is what autoimmune is it's the body mistakenly attacking its own self And so this is where I agree with Becca. I see it time and time again the graves turns into Hashimoto's and then I would be curious if you've seen this but for most of the cows that I've worked with their endocrinologists are like we don't really know Like how do we handle this from here because they've given the medication to try to slow things down We'll now you're too slow. So what I'm going to do and try to rev you up again Right and so some some people can go back and forth and this is really where when we address the underlying dysfunction And I would say as we were just talking offline root causes Like what is stimulating your immune system? What is driving this molecular mimicry it the body to make these mistakes That's what we have to figure out and it's multifaceted It's definitely and I will say this and stand firm Until my grave It's not a medication deficiency that did not design us with all of these medication deficiencies It's the world that we live in and the way that we're not compensating anymore. So the toxic burden has become too high The stress has become too high right your body is starting to mistake Things for self and that's really where autoimmunity comes and it can just be you know widespread So we see a lot of times two people who've had one autoimmune Typically get another autoimmune and a third autoimmune right the second and third and so really How do we go in and how do we address this one? We have got to calm things down or we've got a support themian system of our already exhausted The gut and you know all of the things within our microbiome the terrain not just H. Pylord CBO, Candida mold right fungal issues. We've got to figure out What's happening in the environment? What's allowing all of these microbes to be imbalanced? Because when they're imbalanced we're driving inflammation and when we drive inflammation we trigger the immune system So again, it all comes down to being immune system and it can be multi-layered and multifaceted So I do think that the you know answer here is really complex But I would guess I don't know right this person or anything else about this story That your inter-chronologists are quite stumped and that there's probably other things going on that you're also trying to figure out Because maybe things just like we've seen with many you know medications have gotten worse because of the side effects And then you know the person continues to struggle. Sorry. I just like took that over I was just thinking about the cortisol situation and I think that that is also how we get in these states Absolutely absolutely cortisol is going to dysregulate everything in the body when it comes to the endocrine system the hormonal system right and I'm not saying that if you have gravestisies you don't need to go on with thymazol and you don't need t3 Suppressing you do need that but you do it alongside Addressing why this happened right gravestisies. It's not a too much t3 problem alone It's an autoimmune condition right and so why is the immune system attacking the thyroid? Why is the immune system active when you go to the endocrinologist? They're just going to give you the medication. They're not going to address your gut They're not going to address your metabolic function your inflammation levels right and gravestisies a lot of people don't They're like oh, I'm losing weight, but like and I'm kind of anxious But once you get on the medication things stabilize so you think that things are managed They're not You still have the immune issue underlying and so you have to address those aspects because Eventually yes your thyroid probably will burn out from the graves at some point But if you can get under control the autoimmune aspect of things you can at least manage it a lot better when it does flip. It's almost inevitable. I've seen a number of graves cases at this point, almost every single one of them. At some point flipped and now we're trying to manage the other side of things, right? Because we didn't do the deeper work of the gut health, the inflammation, the metabolic health, all the things that affect autoimmune. So some people are predisposed to this. Graves is genetic, thyroid issues can be genetic. That's not the only thing, right? There's so many other pieces. Like in a healthy system, the thyroid shouldn't necessarily be a problem, regardless of genetics. So yeah, it's, you got to look deeper, right? And unfortunately, an endocrinologist isn't probably not the person that's going to be doing that. They can manage the medication side of things and they can test the hormones for you and test the thyroid, but don't just test TSH, don't just test T3, test reverse T3, test your antibodies, test all of those things consistently. And the last thing I'll say here is, although I think antibodies can be helpful, I also don't chase antibodies all the time. Like you, antibodies are going to go up and go down depending on like viral load, depending on if you're working the immune system. And so I really try not to just put a ton of weight on that. I put a weight on how is this person feeling, how are symptoms being managed? What phase of this work are we in? Because from stimulating the immune system purposefully, your antibodies are going to go up. If you're sick, your antibodies are going to go up. Like you can't just, oh, but these are my antibodies right now. Okay. What are we doing? What are you doing to improve these things? I do like to see them go down over time. Yeah. But it's not something that I'm like, oh, shoot, this is a problem. What can we do to fix it? It's like, no, keep the bigger picture in mind and address the bigger picture. Yeah. And this podcast that we did with ION is not going to be out yet. But one of the things that we talked about with him too is addressing, you know, the thymus and really supporting that. And a lot of times in autoimmune cases, especially with, you know, thyroid, I'll be putting in like a thymogen alpha one right along with maybe some other thyroid bio regulators. And obviously the thyroid supports a big thing that often gets overlooked too is selenium and iodine, right? We know that zinc and all of these other cofactors are really important for the thyroid hormones. But if we're actually looking at a conversion, we have to look at the gut and the liver because that's where the largest conversions happen to outside of just the tissue. So there's a lot more to look at. And I would agree with Becca, I wouldn't chase your antibodies, but over time, right? If you're working with somebody for a year, two years, we would want to see that we're trending downward, right? And we're moving in the right direction. As also we're trying to correct other things because a lot of these cases that we work are coming in with chronically low white blood cell counts to I just had a story that I shared on my Instagram. It's probably even a week or two ago now before we traveled. But I was so excited because this woman has been a chronic low white blood cell for a long time. And we've gotten those up. We've rebounded a lot of the different types of white blood cells to and regulated those and gotten her out of a state of ironemia. So there's a lot that we have to manage. And just again, when you're going through the process, it is so complex. It's so multifaceted that we can't just react right to one lab marker because maybe you're, you know, due for an annual appointment and it came back. Well, like we see this all the time. My liver enzymes are elevated. Yes, we're in a deep detox phase right now, right? We're in deep fasting. We're getting into cellular, you know, autophagy. We're going to probably see, you know, the liver is processing things more. So let's get into a couple of the other questions and I was bad. You didn't put the name. I didn't put the name, but I got to girl. It's right here. So this first one is the Jenna. The Jen Atkins 11. I actually already spoke with her this morning, but in testell, met a place on my daughter's pathology. Young and healthy is this fixable. So first, what is this? This is a precancerous condition where the stomach or esophageal lining changes, replacing normal cells with intestinal type cells due to chronic irritation. How do we address this? What are things that can really drive this and, you know, be irritating to the esophagus and the lining of the intestines? Well, number one, in the research, this is linked to H. Pylory. And this is where I want to go a step further and say, number one, there are a lot of false positives. There are a lot of false negatives with H. Pylory breath testing. Okay. So you have to, in my opinion, do both if you want the breath test, cool, but stool test and GI map is very sensitive. One of the things that I appreciate about the GI map is that it gives us multiple virulence factors and it tells us that they're positive or they're negative. And I think in this case, this is, if this was my daughter, I would be doing a GI map and I would be doing an MRT test, a mediator release test. So we'll talk about that in a moment, but let's go into why the stool test would be so helpful for the virulence factors. Virulence factors give us a little bit more about the pathology and the morphology of this bacteria. So it's not just is the bacteria present. It's asking the question of how prevalent is it? So what level the GI map is quantitative? It's a DNA analysis. And so it's also going to show you how this is going to behave. So if we have positive virulence factors, this is going to be a greater risk for gastritis, cancer, ulcers, all these types of things, how it's going to damage cells, how it's going to invade our tissues and trigger the immune system. So again, it's not just the pathogen there, it's how is it acting? There's two that I want to call out because these are the most well researched and hopefully your GI doctor that you're working with understands these. If not, links in the show now let's book a call. Let's do these two tests for your daughter because I fear if this is already showing up on pathology that it's only going to get worse unless it's properly addressed, right? That's typically help things, you know, go. So CAG A cytotoxin associated gene A, this is a heavy hitter, this is a lot more inflammatory. So what this can do is inject toxins into the stomach cells. Here's where we're going to be thinking about our parietal cells. Okay, parietal cells are also very important for producing stomach acid, right? And when they're damaged, stomach acid will down regularly and that's going to leave an open door for more infections, but also maybe lead to things like poor protein absorption, right? Break down deficiencies of food because stomach acid helps us protect us from invaders, neutralize any pathogens like parasites, viruses, bacteria, things that are coming in through our water, our air, our food. But we also want to think about how does this help us break down our protein so that we can get those amino acids and build our body up. It's going to disrupt normal cell signaling. And again, like I said, it leaves us at a higher risk of this gastric cancer, ulcers, gastritis, as well as a higher risk of the intestinal metapalasia. So that's one thing that you've got to rely on. The second one is vac A. So this is evacuating cytotoxin A and this is cell damage and tissue breakdown. So this creates holes in the stomach cells. Wekins are stomach lining and promotes immune dysfunction. What does all of this mean? This basically tells us as practitioners that we need to go in harder. We need to address this, we need to maybe put more soothing supports in, we need to do more immune calming supports. This is where that mediator release test could be very valuable. On the mediator release test, this is the gold standard of any type of food sensitivity testing. It's not really sensitivity testing. This is actually looking at how your immune system is being triggered by 176 different foods and chemicals. And those chemicals get even more into the weeds. But that's a different story for different day. This is going to help us look at a scinaffil activation, right? So our her scina fills above a three on her blood work. I would guess that they are a scinaffilictic esophageitis, EOE. We would always want to run an MRT with this as well because that's inflicting an immune response, right? So a scinaffil activation, mast cell activation cytokines. Like we want to remove all of those that are triggering the immune system so we can calm down the storm, eradicate any pathogens that may be driving this inflammation, soothe the inflammation, right? And then work on healing and sealing the lining of the gut so that we can hopefully prevent this turning into something very serious, very damaging. So I say all this with so much love and compassion for what you're going through. I don't know how old your child is, but absolutely as a mother, these are the first two things that I am running and I'm going full force in with a practitioner who is very experienced and knowledge in this field. We actually just spoke at the hybrid health summit and someone asked us about H. Prylory and this reoccurrence and all these things. And I think that the stool testing is invaluable because it tells us what do I need to be doing is my treatment working right upon a retest at the right time when it's appropriate, but then also looking at other factors like environmental factors, the house. So I was even sharing, I know Becca was talking about this too, but like your oral microbiome, right? We have a lot of microbes in the oral cavity, but we also share things with our saliva. And so am I sharing knives, food, sports, you know, kissing, those types of things in a home. The story that I just shared of my client on my Instagram last week, Melissa, we've now addressed her children's help, all of them, all four of them in the home had high levels of H. Prylory. The husband didn't have high, but the children did and so did she. She was on a proton pump inhibitor. So this spreads very easily. It can be with crowded conditions like water supply. There's a lot of ways they can get H. Prylory. So it's pretty common can be passed down from mother intro, utero as well. So when you're addressing H. Prylory, it's got to be a full comprehensive approach sometimes depending upon the pathology, we need to put in a proton pump inhibitor or acid reducer temporarily for six, eight weeks, maybe. And then on the other side of that once it's gone, rebuild the stomach, asset levels, but those are other things to kind of be thinking about as well. If this person, you know, is living in environment, what's going on with mom and dad, what's going on with other children? in the home, what are they experiencing symptomatically? I could go on about this for hours, so I'll digress here, but just please, whatever you are going to do, get with somebody who's experienced links are in the show notes with our team. You could even run these two as a test, you know, one off in our practice if you wanted to, but we typically don't run stool tests as one off because we want to see this through. We want to know that that person addressed things comprehensively because I don't want to be that practitioner like many of the clients we get, who left a lot of things undone and then things are coming back or they're not fully resolving. Yeah, I just think it's so interesting with the body does. Like it literally changes how the cells in the stomach function to protect itself. Like the Liz was talking about the metaplasia and it's an early sign of cancer development in the GI lining, but essentially your stomach cells that should be able to produce acid and absorb nutrients and I'm sorry, not absorb nutrients, break down food, start looking more like intestinal cells where they shouldn't and they does it to protect itself because of the chronic inflammation going on. But then typically those people start having issues with not being a little break down protein and not being infealing a lot of like bloating and the reflux and all these things because ultimately your body is not doing what it's supposed to do to protect itself. It's crazy. It's crazy what the body does. I'm just like constantly fascinated by it. So next question, little switch of gears. This comes from @lifewiththeleons. I like that. That's cute. Rute cause of heat intolerance. Heat intolerance. So first question I would ask is like, when did it start? If it was more of a sudden onset, I would think probably some type of immune trigger. So you know, viral was it COVID? After COVID, it happened. Was it after a vaccine? Was it after a medication change? Right? If it was more gradual, I'm thinking probably like gut detox capacity, chronic inflammation, hormonal shifts like paramedic paws. But in almost every case of heat intolerance, we are looking at some type of a histamine issue. So histamine is a vasodilator, meaning it opens blood vessels. And when histamine is high, you typically get extreme vasodilation. Right? So this means people get flushed. This is why hives happen. Right? Overheating, dizzy lightheaded, heart racing, heart palpitations, right? All of those things are histamine responses because that's what histamine causes. So you're basically over responding to heat when you shouldn't. And on top of that heat itself, can trigger mass cell activation, which triggers more histamine. So it creates this like awful feedback loop that happens of heat getting out in the sun for too long. And sometimes we even see it when they got they're in the sun, it's not a problem. But when they go back into cool, it's a problem. So like the body's inability to cool and regulate itself, it can happen both times exercise is another big one that a lot of people experience. But usually histamine becomes a problem because there are underlying gut issues. This biosys or infections can ultimately increase histamine producing bacteria. And you can see this on a GI map. Specific strains of bacteria are overproducers of histamine, low DAO activity. So we'll see this sometimes with genetic testing that people are impaired in their ability to break down histamine and histamine aces and neurotransmitter ultimately. And so it has to be degraded and detoxified like your serotonin and dopamine and all of these things. And so when that doesn't happen very well because you have methylation issues or you have you know, luteus ion transferase are all these different phase 2 detox issues. Then you don't break down your histamine and it just compiles and then it causes high levels of histamine and the body can't handle that. And so we get histamine symptoms. Viral issues. So chronic viruses, EBV, long COVID, all those things basically keep the immune system on and active. It's not that those things are necessarily the problem anymore. It's more so that the immune system can't calm down. And so viruses become more active and irritating to the system. And that keeps mass cells more reactive. Detox and clearance issues, neurotransmitter imbalances, hormones, so estrogen increases histamine release a lot of times, especially in people that already have underlying issues in that area. So maybe when you had healthy cycles that were normal and cadence alongside progesterone and it was nice and balanced, you didn't experience these issues. But then perimenopause hit your body struggle to handle the really extremes highs and lows of estrogen, which is more so the problem than low estrogen or high estrogen. It's the shift in estrogen that is the problem in perimenopause. And so it increases histamine release, histamine stimulates more estrogen. So basically what's happening in the body is histamine becomes high, blood vessels open too much. And then the nervous system becomes more reactive because when you have too high of a blood flow, it also stresses out your body. And so the nervous system gets like, whoa adrenaline starts pumping and then it becomes kind of this like massive negative feedback loop happening. So the body struggles to regulate temperatures that you should otherwise be able to regulate. It kind of shrinks the thermostat, right? If you used to be able to be fine in like up to 90 degree temperatures and down to 65 degree temperatures, now you're can only handle like 82 to 74, right? My husband thinks this is me. He's like one degree difference and you are a problem. I think it's all women. Like that's me honest. I am either sweating or freezing. There is no in between and there is. It is short lived. No, but if you are like breaking out in hives, you're flushing, you're having extreme headaches or anything like that, you most likely have some level of histamine issue going on. Yes. All right, so we got a couple more and we will keep these quicker because I know back and I have to rant on one of them. But Haley Kay Henderson, toxic free living where to start. So I love this question. The thing that I would say here is don't overwhelm yourself because I see so many people because of social media, of course, right? Getting overwhelmed, but then they just don't like do anything or they're like, well, it's all going to suck in terms of it's not going to clean very well. I would say start with number one, the things that you use every single day. What are you putting on your body? So like think of your personal products. So your hair care, your skin care, what are you using? It was like body wash and lotion like face all those things. Back in I both love all of beta. We use that for skin care. You know, in terms of hair hair, I think everyone is so different. What I would recommend is doing like the EWG like shampoo. There's like a clean list there or you can do the app. There's a few different apps that are free for non-tuxi-cliving and you can just go and scan them, linking on the name of one of them. But I'm starting with what I use every single day. I'm also thinking about in my home, right? So my dishes and my laundry because ultimately I'm doing dishes every day and I'm doing laundry and wearing the clothes. We also both love turnily free and they are affordable and they do a good job. I know for my husband and actually my service just here visiting and we were talking about like me, no, my brother-in-law and what does he think and she's like, he's the type of guy like what works just works. He doesn't necessarily want to change things. So she's had to over time right introduce these things and then he's even surprised. Oh, this actually does a really good job. Like I was trying on my stories yesterday. My husband very kindly tasked me with degreasing our grill in this grease tray and it, you guys, it was so bad, it was so foul. I was like dry heaving and disgusting. And he came back and he helped me with it. But being truly free, heavy duty degreaser, that stuff is amazing. And my sister has even said she's used it at school and works. So anyways, I'm saying all this that I would use the things that you're using every day and I would go with what's affordable. And then as other things, you know, you run out of those make swaps. So we can share but we have a truly free link and a coach should just be fit mom. They do a lot of different like sales and bundles like the whole home bundle is really great. The best seller bundle is right now like $39 and that gives you everything for your laundry. The stain system. So having two little kids and then white sheets and white towels, I think it works really well. So they've got enzymatic stain removers. The oxy boost, it keeps things white and bright. And I think that it does a good job. Now I'll take a step further here though because I'm a laundry snob and I need my stuff to smell good. So I cannot do just like the free and clear or any of those things. I need my stuff to smell good. So I pair my truly free laundry with to paying a sense. It's like two to four ounces and they got all different kinds like hotel scent. The grove is my favorite. Malibu appears another one and they've got like fabric spray and stuff. So you know, if finances aren't like a big issue, I would pair that together but I would definitely start with a truly free and everything else, you know, just kind of be thinking about what's your exposure to it? Perfume and whatnot. Like I'm not the type of person that wears perfume every single day, but I do love dime. It is a hormone friendly, no-intercundristerupting perfume, cologne. My son uses their cologne. My husband uses their cologne. A lot of people like that for men. It's the number one, it's the black bottle. And I don't know. I like all of their perfumes. I like seven summers. That's my favorite one. I wear that one. I typically wear perfume daily. But just like a little spray or two. I'm gousing myself. You're like a sprayer too in the morning. And because it's cleaner, I feel less bad. Yeah, I mean, I would say like before having that, I would use, you know, a couple of things that I like that aren't undercrumbed disrupting free. Like, I will say I still like on a date night or something fancy, you know, for going out to a nice dinner or we have an event. I'm probably gonna wear that just because I like that. I'm thinking of like Chloe. It's one of my favorite perfumes. But in the day to day, just all of the things that I would put on. Then I'm keeping it to like the dime and like those clean products. So I know that got long-winded, but just do the things that you daily look up truly free home. There's a lot out there. I don't think you need to do spending massive amounts of money on all of this stuff. Yeah. Okay, we're gonna wrap up with this one. And then This is from TROX, Strux, SHROKS. Diagnose with mold of SIBO, H-Pylaury, MTHF-R gene, and Paryment of Oz, where to start. First of all, these are all interconnected. So if we go back, and I always like to say, take a 10,000 foot view, and we're looking at the environment that is allowing fungal, mold, microtoxins, right? Small intestinal bacteria overgrowth, H-Pylaury to thrive, I'm gonna go and say chronic stress, low stomach acid, because chronic stress leads to low stomach acid, combined with MTHF-R. Here's the reality. MTHF-R is one of many genes in the methylation pathway. Is it big? Yes, is it buzzing? Yes. Does it impair our ability to methylate? Yes. But is that a root cause? I don't see MTHF-R as a root cause. I think that when we look at your genes and your genetic predisposition, we have to understand what influences them. So when we have chronically elevated stress in our life, and we down-regulate our stomach acid production, that impacts our B vitamins, and for methylation, B vitamins is very important. So B12, B9, fully, right? We think about these as the big cajunas, but there's a lot of other things in terms of colon, trimethoglyceum, with thionine, all of these that can influence your body's ability to methylate, right? Or to add a methyl group to something and be able to remove it from the body through your feces, your sweat, your urine. On lab work, we can look at serum markers for homocysteine. We can look at B12, we can look at fully, but most importantly, we're looking at homocysteine because that's telling us how is your methylation process actually working in the body. But again, you're saying diagnosed. This is all about the terrain. This is all the environment that is allowing the bacteria to grow. So if I'm saying how I'm going to address this as a practitioner, number one, I'm going to support the system first. I'm going to come in and think, top down from a digested perspective, you have to address things north to south. H. Prylorium resides in the stomach region. If we have H. Prylorium in the stomach region, we for sure have downstream issues, especially if we're not going to the bathroom regularly, because all of that is going to just sit and kind of feed and ferment proliferate in the body. So from a small intestinal bacterial overgrowth and the mold aspect, along with MTHFR, I'm thinking liver gallbladder. Lack of bioflow filtering through the small intestine, immune gets stimulated. We have upregulation of the immune response. We have downregulation of anti-inflammatory activity. We were probably seeing some metabolic issues here and dysfunction, especially because we're in paramedic haus and estrogen needs to be properly processed and removed from the body. Part of that has to do with methylation. So it's very complex, but I'm going to come in and I'm going to support the system first. I'm going to give stomach acid, as long as the person is not having acid reflux, heartburn actively, if they are, then I'm going to support soothing. Then after that, coming in with stomach acid support, I'm also going to support my methylation pathways. And again, I'm going to use labs and symptoms to help me identify what is the most important. In general, I don't recommend methylated B vitamins, because for some people, against stimulate them, they become very anxious and moody and much more dysregulated. So I would go in with maybe just something like, or excuse me, full-in-elite acid or full-ate, or you could use like, Colleen or tri-methaglycine or a dental cell cobalm. There is a pure genomics B complex that we like that's a non-methylated complex for MTHFR and the whole methylation pathway. That's great. If you aren't stimulated by methylated B vitamins, then I'm probably going to say maybe a homocysteine supreme, because that's got NAC. It's got some other methylation factors in there. I'm going to support liver, gallbladder and bile flow, absolutely, because you will never get rid of the SIBO. You will never get rid of the mold mycotoxins if you're not having bile flowing fluidly and making sure that you're pooping every day. You're adequately hydrated. You've got minerals. You've got all the things that you need to support the system and eliminating all of this before you go in, at least for me as a practitioner, with heavy eradication agents to get after these pathogens. But I'll let back I continue this, because I just really get frustrated when people are like diagnosed with this stuff. This is not, this is maybe a contributor. How did that diagnosis help you? Yeah. I mean, sure. Now we know the extremity of what we're dealing with. We know that bolts potentially a problem. Are we still living in it? Like Liz was saying. So the thing that I think about too is I have a feeling unless you moved into an extremely moldy house and it started as soon as you moved in. I have a feeling this didn't all just pop on one day. I have a feeling there were probably symptoms lingering for a while until there was maybe a catalyst, whether it was paramedicot shift, whether it was, you know, moving into a home, whether it was a viral activity, but like something was going on that was probably ignored or not properly addressed. And then it just worsened and worsened until I have to get all this testing and figure out what's going on. Oh my gosh, I have SIBO. I have mold toxicity. I have all these things happening. And so I struggle with the lack of addressing and acknowledging what was probably happening for a while. Most of these things, SIBO doesn't just happen. It doesn't. It's a process and it accumulates over time and it typically happens because the immune systems really dysregulated. It's not just a gut problem. So yeah, I would agree that it's much bigger than, you know, I have these diagnoses now. Okay, so what? So what? What did they advise when they diagnosed these things? What type of SIBO is it? You know, what are we doing to maybe adjust our diet and bring things into support, right? But like Liz was saying, you have to start top down with stuff like this. You have to make sure I would say top down and bottom up, right? We got to make sure we're having good bowel movements. We have to make sure that we're eliminating properly. And then we have to address from the top down to make sure that we are getting all of the things that affect what is going on in the intestines because the intestines are not the first in this little path. Yeah, and the last thing I'll say here is that diet really matters. It does not resolve things entirely in terms of, I know a lot of people will go low-fod map because it's SIBO or they'll go on a Candida diet, right, or an anti-mold diet. And I think that can be helpful. But diet diversity and incorporating different strategies that help you specifically with your symptoms and metabolically, being metabolically flexible, getting into cellular autophagy. If we are getting into autophagy, regularly, these things don't proliferate long-term to the point that we see them proliferate. The problem is that so many people eat and they snack and they graze way too much. Or on the opposite end of the spectrum, they do so much fasting that now they've broken down their mucosal barrier and they got lining and their body. I mean, you're going to down-regulate stomach acid production just because of the stress of fasting as well, right, because you're not bringing in things that your body needs to build things up. So again, it's multifaceted. We in our practice believe that it should be a holistic approach. So by that, it's, yeah, the testing is great. Now we've identified what's here and what we want to get in an address and the strategy and the path forward to help you understand why I have all these symptoms. But that needs to be married with your lifestyle, right? Again, going back to what I mentioned before, chronic stress that's probably, you know, chronic stress on the body and toxic overload and burden all of these things that have led to this spill over, right? To where the body is no longer handling things, immune system can't handle it. That matters a lot. Training, back in I, we're having a conversation earlier. I'm chronically bloated. Okay, well, you're training 90 minutes a day and listen, I don't want to throw shade on this because we both did 75 hard. I did it twice. I was puffy and inflamed. My body was not handling that. I don't know how I did or why I did that because even just this past weekend with moving in everything, I was like fully mully. I don't know how I did 75 days straight of 90 minutes a day. Granted, it was split up and granted it was more bodybuilding style combined with like outdoor walks and it wasn't always intense. But either way, that level of movement on top of just normal life moving around, that's a lot of stress. And so yeah, when your body's pulling away energy that it needs for digestion, you're gonna be left with some of these digestive symptoms. Those stress has to be addressed. Your training needs to be addressed. Your lifestyle in terms of, again, how you know, you were living, if you're traveling, all of that should be a consideration and the dietary strategies along with maybe the supplements or peptides or whatever is that you're gonna go in after with your practitioner. And I would just ask them to kind of explain the strategy to you and explain the phases to as well because this is definitely going to be a phased approach. I'm gonna tell you, I'm thinking nine to 12 months to address something like that where we see the whole terrain is being impacted by these pathogens. It's gonna take some time to peel back the layers of the onion, it's gonna take some time to undo the damage and rebalance the microbiome. So just sharing that, you know, again, as with all the love we like to be open with people and transparent that this stuff takes time because like, because that it doesn't just happen, you know, overnight. So if you guys like this episode, don't forget to rate, review, subscribe, share the show, tag us, share it on social media, at the Boop Queen, at the Hormone Queen, and FitMom Functional Health on Instagram too. So with all of that, we've got other podcasting to do this afternoon. We'll be back in another episode very soon. (upbeat music)