#889: Q&A with Tim — How to Get Unstuck, Resilience in Hard Times, Tools for Brain Health, Finding Inner Peace, Optimism as a Learnable Skill, and More
from The Tim Ferriss Show ·
1h 14m 29s
Tim Ferriss outlines a comprehensive, science-informed strategy for managing his genetic risk of Alzheimer’s, emphasizing early prevention and lifestyle interventions such as regular saunas, interval training, and targeted supplements. He critiques current medical approaches as outdated and notes that neurodegenerative processes begin decades before diagnosis. Behavioral change remains central, with tools like fear setting, cognitive behavioral therapy, and habit stacking to help break entrenched patterns. To maintain mental resilience amid a culture of pessimism, Ferriss advocates for structured "upside time" and "downside time" routines—deliberately seeking hope and risk—to counteract negativity. He cautiously supports psychedelics as powerful diagnostic and therapeutic tools, especially for uncovering hidden emotional patterns, while warning of their risks and variability. He strongly cautions against unregulated supplements, stressing the need for standardized testing and proven efficacy, especially in areas like cholesterol management. Ferriss promotes hands-on learning with AI and self-building projects as effective ways to stay current. He also reflects on the limitations of self-tracking, arguing that data volume overwhelms insight—true value lies in actionable interpretation. Ultimately, he champions a holistic, proactive lifestyle where mental resilience, behavioral change, and evidence-based decision-making converge to build long-term health and adaptability.
Hello, boys and girls, ladies and germs. Welcome to another episode of The Tim Ferriss Show.
This is the second half of a Q&A recorded during a recent live stream, but this second part is
totally self-sufficient. You don't need the first half, so don't worry about that.
If you want to listen to the first half, you can find it at tim.blogs.podcast very easily.
We had so many questions that we had to split it up. And we pick up here with how I'm approaching
my own Alzheimer's risk, genetically speaking, how I'm thinking about that.
And then we get into breaking stubborn patterns, how I think about behavioral change,
habit formation, et cetera. Staying optimistic. I think this is the mother skill. Certainly,
I'm not the first person to say that. But in a world of creeping nihilism and darkness,
how do you stay optimistic? What is the value of staying optimistic?
How do you distinguish that from being a Pollyanna, in a sense, right?
Next, let's talk about how you can stay optimistic.
Learning AI by building things and the limits of self-tracking. How would I think about the
quantified self now versus the very first meetup I went to ages and ages and ages ago?
I also get into, and somewhat hesitantly, but I wanted to answer the question,
how psychedelics have changed my life or affected me with lots of caveats and warnings.
Supplements versus prescription drugs. How do you think about that? Drugs in quotation marks
versus all natural in quotation marks. How do you answer, how do I answer the question,
are you at?
Peace. Tough one, but we'll get into it. And much more. Thank you again for the
incredibly thoughtful questions. And with that said, please enjoy part two.
Next one is from Mary. I know Alzheimer's prevention is a big focus for you. Can you
give a concise listing of the preventative measures you are taking, including drugs,
all therapies, i.e. TMS, hot, cold, et cetera, food, and movement. Mary, you're in good luck.
In fact, I already have a draft of a blog post that is also going to be turned into a podcast
where I'm going to go through all of this in excruciating Tim Ferriss detail. But I'm going to
give you a few things that come to mind, and there will be much more in terms of detail
and non-obvious choices. But I'm going to preface it by saying that we are in the dark ages still
with Alzheimer's and many neurodegenerative diseases. Having shepherded a few relatives
through treatments for Alzheimer's, I will say that it is primitive AF. And many of these drugs
are a Faustian bargain. In my opinion, I have access to a lot of great researchers,
and there's very little consensus on the best way to try to address these things.
I would say the only consensus I can point to is that prevention is the name of the game.
And these processes, at least as we currently understand them,
that culminate in what we would diagnose as, say, Alzheimer's, start pretty early, 30s,
40s, right? So I won't get into all the mechanisms of action that I think most interesting because
that's beside the point you asked what I'm doing. Some of what I'm doing, sauna a few times a week,
20 minutes, somewhere between 170 and 180 degrees. Hotter is not better. You can look at some of
Dr. Rhonda Patrick's coverage of the research. You don't want to overcook your head. That is
going to push you in the wrong direction, not the right direction. Interval training, Dr.
Tommy Wood and I talked about this at length. It remains, I think, one of the most interesting
interventions that I've come across, certainly, at least as supported for maintaining hippocampal
volume in the brain. And we can talk about the importance of the hippocampus another time.
But doing this Norwegian 4x4 training, which is hard, I'm going to warn you, it's also helpful
for VO2 max, and we can talk about how that's correlated to all sorts of good things. But
you're basically doing four minutes.
Of all out intense exercise, like by the last minute, you feel like you're going to die and
you're being chased by wolves, getting to a very high heart rate. I use a heart rate monitor,
Morpheus, for tracking all of this. And then you take three minutes off, and then you do four
again, and you do four rounds of that. Okay. Doing this, I think it was three times a week
for six months, produced durable changes out five years, if I'm remembering correctly.
That is nuts. That is pretty wild.
Is that the perfect protocol? Is that what you need? We don't know, but the evidence so far,
at least it's been documented, supports that. There are other things you can do. Zone 2 training,
certainly for mitochondrial health. Urolithin A is a supplement I've decided to take also for
predominantly mitochondrial health. We don't have time to dig into that, but I do find the research
there pretty compelling. You can buy that on Amazon or online. It's produced by a company called
is their patented Urolithin A. And there are other things that are light lifts. And again,
I'm not saying any of these things cure Alzheimer's. I think by the time someone's far gone,
it's pretty much far gone. However, five milligrams of lithium orotate, do take five
milligrams of lithium orotate. That is also OTC. You can get it easily. And listen to my podcast
with Tommy Wood, tripling down on dental health.
Air purifiers, water, creating systems such that your environment and your routines are as
supportive as possible. I have become a huge fan of, so in the case of dental health, for instance,
using gum or mouthwash that includes xylitol. And don't have time to get into it right now
in great depth, but a blog post and podcast is coming. That's going to be dedicated to this
with the enormous grain of salt that I am not in the middle of.
of treating disease. However, I am genetically predisposed to Alzheimer's with ApoE3,4 and other
risk factors. So I am throwing the kitchen sink at it or everything in the kitchen sink, I suppose
the expression goes. So thanks for the question, Mary. Hopefully that is somewhat helpful, but my
blog post and podcast will have a lot more. This is from, I think a different Susan. I've spent
nearly 30 years practicing acupuncture and previously worked as a psychotherapist. I
want to heal while unconsciously holding under the very patterns that keep them suffering.
Have you ever recognized exactly what was keeping you stuck? You have found yourself
unable to let it go and will finally allowed you to. Oh yeah. All the time.
I mean, just look at anyone's new year's resolutions, mine included. And look,
I do the past year review and I've got my behavioral engineering and so on, but there's
still things that I can see. And I remember hearing Sam Harris talk about sorting other
people's problems out. It's like, you can sort out other people's problems in two seconds.
Yeah. Giving advice is easy, but actually moving into the catalyzing stage where you translate
good intention to behavior is something else. So psychedelics, I'm not going to spend a lot
of time on. They do allow you oftentimes to step outside of yourself as the protagonist in your own
movie and watch that movie on a screen as someone in the audience. So it can be very helpful for
developing an awareness and opening a window of opportunity for rewriting some of the beliefs and
patterns that govern your life. But outside of that, IFS, internal family systems created by
Dick Schwartz, I think is very useful. No drugs required. Although it is often implemented in some
form in the preparation and integration for say MDMA-assisted psychotherapy. CBT, very helpful,
might not be sexy, but in large part originating out of stoic philosophy. If you have not looked
into the Genesis story, it's actually a good read. But CBT, cognitive, cognitive, cognitive,
behavioral therapy, very interesting. DBT, also very interesting. People can look that up if
they'd like. And Atomic Habits, I mentioned it once before. There's a reason it sold 25 million,
30 million copies. Good God, non-recurring phenomenon. Good for you, James. And the last
two things I would say is that the pain has to be painful enough. Sometimes people just aren't in
enough pain to change. I mean, I've seen this with addicts over and over and over again. I've
sadly had family members who have died from addiction. I have best friends who have died
from addiction. I've had best friends who have died from addiction. I've had friends who are currently, have friends who are currently
addicted. Sometimes they have to really hit rock bottom. I hate to say it, but sometimes the pain
isn't painful enough. And then last but not least, I'll mention fear setting. People can find fear
setting, which I've talked about quite a bit before. A TED Talk, which has God knows how many
views now, I don't know, many millions, focuses on this exclusively. I think tim.blogs.ted will
take you to that. And you can find it online for free. You don't have to buy anything. There are
this fear setting, which is intended to methodically remove different emergency breaks in
your life, which are nebulous fears or inhibitions of one type or another. But there's one aspect of
fear setting. It's the piece that is most neglected and most applies to this question, which is
describing in writing the cost of inaction. And so what that looks like, you can take a piece of
grab a piece of paper, I like doing this analog,
create three columns,
you got one year three years ten years and then put at the top whatever it is that you would like
to change and then you have cost of inaction right so now you have three columns with three
timelines and in each of those columns you're just going to write down if nothing changes if you
continue doing what you're doing or not doing what you're not doing what are the costs physically
financially relationally whatever it might be one year from now three years from now could be five
years pick your poison ten years from now and chances are if you get to that stage with something
the picture that it paints that is let's just call it nearly inevitable is not going to be pretty
and that is how you take something that isn't currently painful enough and you magnify it
with a reality
accelerator to make it compelling enough so that you make a change recognizing that the change
involves less pain likely temporary less risk also probably reversible than the status quo
we think of risk or downside risks or problems as the byproduct of something we do that is new
but we don't often take the time to consider the atrocious cost of the status quo and inaction all
right
i'm going to come back to that seed that i planted earlier this is a question from jason remember the
format question i planted here's the question from jason a hey tim i've been a big fan since
four hour work week i have all the books it was in a test group for coyote thank you for that
appreciate it that was a fun little experiment with the card game really appreciate you and
everything you do question i really love the more relaxed and less polished format of the
random show in the q and a's wondering if those are less effort fuck yeah they're less effort
for me
okay wondering if those are less effort for you compared to the researched intentional guest
episodes yes i put a ton of time into those and it seems like there are just too many interview
format podcasts in the world at the moment okay i know i'm interjecting with my own director's
commentary here any chance you would pivot towards a more consistently extemporaneous format in the
future yes i've wanted to do this and i have had a number of different thoughts on how i might
experiment with it i've done a lot of research and i've done a lot of research and i've done a lot of
research and i've done some co-hosting experiments in the past you might have noticed where i've had
say kevin kelly on good friend of mine and they invite the guest and we both interview them did
this with danny hillis amazing amazing such a fun interview and for me those are extemporaneous
more extemporaneous i think that that may not be as obvious to the listener or to the viewer but
that is the case and i am eager to hear what you would like to say about the podcast i'm going to
see me do so please add in the comments what formats you would watch or listen to what you
think could be fun for me to experiment with i am very very interested in this so of course as i am
doing this in real time we have a feed of comments i'd love for you guys to drop in a bunch of
comments but if you want to gestate and come back with a suggestion
you can also shoot me an at reply just tag me on x at t ferris t f e r r i s s and use hashtag format
in that tweet somewhere so that's the ask i would love your input i would love your thoughts
recommendations for experimental formats this is something i really would like to do because
it's fun for me to do it's lightweight but i get to exercise my brain
more in some respects than fixed format interview i think interview formats are largely dead i think
almost every interview based format in the world of podcasting aka if we're looking at the latest
vintage television shows on youtube are basically islands in the middle of the ocean with a rising
water level and it's not a question of if they will be consumed
it is just a matter of when with respect to ai and other things i've talked about the canary in
the coal mine which is prescriptive non-fiction in the form of books i published my sales numbers
and so on looking at trend lines post introduction of chat tpt 3.5 in i believe it was november of
2023 and there are many reasons therefore that i would love to experiment with this and let me know
i would really love to take a stab at it so keep dragging them in i will have
access to this chat after we stop the live stream and certainly i will be watching the
specific tweets that go up with at t ferris and hashtag format so please do let me know
there are lots of questions on translating thought or introspection or brainstorming to action
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this is from
vedant how do you stop being an intellectual collector and start being a builder honestly i
would look at some of the older videos by casey neistat who was a very famous still is a very
famous creator who's had the longevity of decades at this point he is very good at verbalizing
and giving a rationale for consistently shipping something whether it's once a day once a week once
a month it can be anything which relates back to developing a bias towards action with the smallest
next possible action it doesn't need to be big but you're reconstructing an identity and then
the identity will lead you to habitual behaviors and that will lead to more output john t as it
pertains to ai 12 months from now what will we wish we were doing today that we aren't probably
more defining and elimination as described in the four-hour work week but you don't need to read the
four-hour work week you could buy books like the 80 20 principle by richard kosh there are many
different options i have already recommended the effective executive by peter drucker these are
evergreen topics that are going to increase in importance question from mitchell as the current
events seem to continue to turn darker and darker how are you staying positive and supporting your
own mental health at this time how are you remaining hopeful what strategies have you
implemented i have not had any social media apps
outside of youtube which i use daily for learning i've not had any social media apps on my phone for
probably five years now i think that is a very simple step that you can experiment with doing a
social media cleanse slash fast for one or two months trust me it's like doing 20 years of
therapy so you can swim upstream against this raging waterfall of bullshit and rage or you
can step out of that and just sit in an inner tube and float down the stream without social
media so in other words it removes the need to do a lot of things when you remove that input
I would say related to this, deciding on in your calendar where you're going to have upside time
and downside time. And what I mean by that is you spend an hour or two, it could be on ChatGPT,
it could be on YouTube, it could be elsewhere, looking for optimistic cases, asking questions
about possibility and opportunities in the age of AI, in fill in the blank, in sector X,
whatever it might be. This is upside time. So you are deliberately putting on your optimist hat,
somewhat echoes the thinking hats of Edward de Bono and lateral thinking, but you're putting
on your optimism hat for upside time. This is in your calendar. This is dedicated study hall.
And then downside time is similar. You are proactively setting aside time to look at risks,
kind of like strengths, weaknesses, opportunities, threats. You're going to be focusing
on weaknesses, threats, and opportunities. And then you're going to be focusing on
risks, threats, risks, et cetera, with the focus on finding descriptions of what can be done.
It's not just a description of the problem. So I would use, for instance,
an LLM as the front end to your YouTube search. And the reason for this is that to the extent
possible, you really want to avoid, in my opinion, a passive feed of rage, nihilism,
and pessimism. And that's what you get if you go to youtube.com and immediately get pulled into
your curated fear, uncertainty, and doubt clips and shorts collection. This is how the platforms
continue to make you the product. Their customers are advertisers. They're selling your attention.
That is the sole purpose of these platforms. From a business model perspective, do not be fooled.
The goal is not to entertain. The goal is not to help. The goal is to keep you on for,
as long as possible. And we have a heavy human proclivity to spend a lot more time
on the things that upset us than things that make us optimistic.
So the approach that counterbalances that inclination is having upside time and downside
time and calendaring it. I would say two other things for me personally. Look at your past.
You made it to where you are right now. There have been recessions. There have been
wars. There have been lots of problems and you somehow figured it out. Sure. You had stumbles
along the way. You probably had some disasters and you recovered from those things. So I am
reading for instance, and this might seem like it's in my downside time, but I would actually
put it in my upside time. I'm reading a book right now called hard times by studs. Turkle.
So studs. Turkle is amazing. One that peels your prize. This is an old book, hard times and oral
history of the great.
And it is dozens and dozens and dozens of vignettes that have been organized thematically
with people who went through the depression explaining in their own words what happened to
them. And you have destitution, but joy. You have people who did better than ever during the worst
of times and they weren't necessarily bankers. A lot of those went the other way. Jingle writers,
for instance.
There's a very, very concrete example of someone who wrote jingles and just had this
outpouring of creative productivity during the depression. And there are dozens and dozens and
dozens of examples, people of every gender, every race imaginable. And it's deeply humanizing
of something that most of us are really only familiar with in a very passing way.
It was a hard period in US history and we've seen black and white photos of women sitting on
doorsteps with underfed children. And we know a thing or two about it. All right. Maybe we know
about the stock crash and brokers jumping out of windows, et cetera. Okay, fine. But that's a very
cursory glance at what was a incredibly important historic event. And this book just personalizes
the whole thing. That's upside time for me because it highlights again and again and again and again
human resilience and how good people are at surviving, recovering, and then thriving after
the fact. So those are a few. And look, not to sound like a shill from my own books, trust me,
I make next to nothing from my books. Then you don't have to buy it. I'm sure you can find it
on Pirate Bay or something. But the meta section of The 4-Hour Chef, which focuses on accelerated
learning, is the most important section in that book. And it's about 80 pages. The name of the
game on some level is. Having confidence that you can adapt in the future. And it's a chicken and the egg situation
because as Mike Maples Jr., a very accomplished entrepreneur and investor, told me at one point,
one of the few things that you're responsible for with your kids is teaching them to be optimistic.
Because if you teach them to be optimistic, they see options. They feel like they have agency.
All right. So does the optimism come first and then the action? Or is it action and
then the optimism? I think it actually points both ways. The arrow is bi-directional.
So reading a book like this, hard times, makes me more optimistic that I can figure things out.
Spending time on meta learning makes me more confident that I can figure things out.
Even if I'm test driving the toolkit on something that seems as trivial
and unnecessary as rock climbing, as is the case currently. Or it could be,
working on portrait drawing, using Procreate, and following along with YouTube videos.
Applying the toolkit. Doesn't matter where you apply it. It's the same toolkit. So if you're
refining your use of that toolkit on anything, you are getting better at cultivating the
metacognition and ability to learn that will give you adaptability in a rapidly changing world,
et cetera, et cetera. And then the social media cleanse,
is in the elimination bucket. It is turning off the torrent of inputs of the trivial many.
And look, I have no social media on my phone. Do my friends still send me the dumbest and most
entertaining memes on Instagram? Do I get sucked into it? Yes, but I can only go so far because I
don't have the app on my phone. So I can waste a few minutes on some dumb, so many dumb things that
I receive every day from my ridiculous friends. I can't waste a few minutes on some dumb, so many
dumb things that I receive every day from my ridiculous friends. And I enjoy it. I'm not
going to lie. Look, the internet is built for entertainment, among other things, sure. But I
limit the damage to the downside risk of my own human inclinations by taking those apps off my
phone. So I'll stop there for now. But those are a few of the things that come to mind. Questions
on Wabi Sabi from Eamon. I'm probably mispronouncing that. Will handmade work and human connection
become more valuable?
In other words, human imperfection? Yes, I do think it will. Not sure quite how to capitalize on that
or what to do with that assumption. But I do think that's definitely going to be the case. I'm going
to go for a bit more. And then I'm headed to the gym. Oh, that's another thing. Yeah, state. Remember
that? Go to the gym or just work out at home. Exercise, folks. Like mind-body separation, that
whole Cartesian duality, a bunch of nonsense. If you want to feed your brain, you want to feed your
mood, you want to be optimistic, fix your state. Exercise. So I'm headed straight to the
gym after this. All right. Ox the moron. That's a good one. Best way to spend $5,000 to $10,000 today
to get current on AI. I don't think you need to spend $5,000 to $10,000. I would use the tools,
create projects, use the tools to help you use the tools. So I would, I guess there are two
thoughts on this. So there is a company called Oboe that I am involved with, but it is custom
designed for learning. Certainly the frontier models are going to be going after this. But AI
for learning. I want to learn. Dot, dot, dot. You just fill it in. Oboe.com. Oboe.com.
O-B-O-E.com. And I would type in, effectively, give me 10 different projects. I am new to AI
tools and LLMs. I want to get more familiar with these tools. Give me 10 project-based
learning opportunities. In other words, 10 projects where I'm creating something
that I could consider for learning how to better use these tools and their various capacities.
Each one, I should be able to finish in one hour, three hours or less, whatever your number happens
to be. And I would also drop that into Claw, drop it into ChatTBT, let them all compete for best
answers. And then you can go from there. I would build things. I would make things. I would try to
automate some workflow. Generally, that doesn't give me a hard-on because I think the definition
and elimination are more important. But making things, maybe there's something beautiful you
want to make. I mean, give it the spin. It's actually going to energize you.
That is how I would get current on AI, is by doing stuff. I don't think you need to spend 5 to 10K.
But whatever the upgraded models are, frankly, even the slower models from six months ago
are plenty. Yeah. Actually, I can't speak out of school, but I've seen some amazing hackers just
to prove a point, use older models to do staggeringly powerful things to say,
hey, we don't need the latest and greatest to actually move the needle.
They're already here, they have been for a while.
on psychedelic experiences. If I'm still interested, if I'm still present, I do still
find them useful. I have decreased my frequency dramatically as I've had other tools to bring to
bear on state and mental health and so on, like neuromodulation. In other words, the accelerated
TMS and the 1D, O-N-E hyphen D protocol that I described earlier, but they still have incredible
applications. I mean, I do believe that these compounds are still one of the most straightforward,
not risk-free, but straightforward ways to elicit some of the greatest adventures that humans can
have on this planet. I still believe that. And insights and touching the timeless in ways that
perhaps the mystics referred to and experienced via other means. I do find them deeply fascinating.
What's new on that front, which is the second part of that question, I would say shorter duration,
there are shorter duration compounds that may have equal efficacy to say MDMA in treating
conditions like PTSD without the typically combined dyad psychotherapy. In other words,
separating the drug effect from the therapeutic wrapper in some respects. Methylone is one at the
forefront right now. I've had experience with this. I mean, I've known methylene for at least 10,
15 years. I've known it for a long time. But it is effectively the shorter acting, gentler cousin of MDMA. And Transcend Therapeutics,
which was co-founded by Kevin Ryan, who I interviewed on the podcast not too long ago,
he also co-founded Business Insider, MongoDB, and Guilt Group, and many, many companies.
But I think that stands a chance of reaching millions of people because it is easier to slot
into the pre-existing healthcare system on many levels. There are many,
many developments in this field. I'll just give you one more that I think is arguably most
interesting to me. And I'm funding research that Chuck Nichols is doing on this. But looking at the
potent anti-inflammatory effects of various psychedelics at doses that are unbelievably
small. So let's just say, I'll give you an example. So in the case of mushrooms, let's talk about dried
psilocybe mushrooms. I mean, we could get strain specific, but I'll keep it simple. If we're
Terrence McKenna's day, a heroic dose would be five grams. All right. If you're taking a microdose
of these same mushrooms, it might be 50 to 100 milligrams. What would happen if you took
one one-thousandth of that? Well, psilocybin is actually not the best candidate, but some of
these other psychedelics, many of which you would not recognize, or most people wouldn't,
at sub-perceptual, but sub-sub-sub-perceptual doses. I mean, almost,
seemingly homeopathic doses have incredibly potent multi-mechanism anti-inflammatory effects.
And I think, pet hypothesis, that many of the benefits we see from psychedelics,
antidepressant effects, and so on, in many, many people, many subjects, even in some of
these clinical trials, are derived from anti-inflammatory effects on chronic neuroinflammation.
And double-clicking on that, that chronic neuroinflammation is often downstream of an
acute infection that you had at one point. It can be caused by many other things. So it's not to use
that as the sole lens through which you explain these things. But those are a few areas that I
find currently very interesting. Matthew, I tried Hugh Jackman's trip for Becoming Extraordinarily
Jacked, which was to row 2,000 meters in seven minutes. I want to hear how that went. Matthew J.,
please let me know if you have any questions. I'd love to hear from you. Thank you.
No, that's quite a tease. Matthew J., that is impossible. Yeah, the 2,000 meters in seven
minutes. Hugh Jackman is an elite-level athlete. Yeah, you might kill yourself trying to replicate
some of what he does. I've easily worked with 100-plus founders and entrepreneurs over the
last 20 years, and I've seen some massive wins, some huge companies built, and some
failures and zombies. Among other things, repeatedly, I've seen how customer service can make or
break a company. This is where FINN comes in. F-I-N. FINN is an AI agent, and people throw that
around a lot. In this context, think of it as a digital employee. And FINN, your digital employee,
delivers high-quality answers and helps resolve complex questions that your customers may have.
And a lot of name-brand companies use FINN. Rapidly growing companies like Asana and Anthropic,
the company behind Claude, and past podcast sponsors like Gamma and Vanta rely on FINN to
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So I'm going to tie two things together. There's a question here from Daniel. Your question here
is, okay, Doc here, building quantified self 2.0 with metabolomics. I do think metabolomics
are incredibly interesting, starting from a real definition of health. Tim, what would
QS 2.0, that's quantified self, I assume, 2.0 have to show you to be worth it? All right.
Bookmark, because that's going to tie in here. Question from John C., that's J-O-N.
Tim, your name came up when Gary Wolf and Kevin Kelly spoke in the Ferry Building last week,
that's in San Francisco, to launch Gary's new book, The Quantified Self. I know you were at the
very first Quantified Self meetup 18 years ago at Kevin's house. It's true. I have a blog post with
from that. I was still white knuckling a little bit of a faux hawk with my remanding hair at the
time. What role has self-quantifying played in your life since then, please? So these tie together
and I will answer Daniel's question and this question. So what would quantified self 2.0 need
to show me? It would need to show me, I would say, a filtered high signal,
version of the lens that I've used for myself with quantified self. And that is a distilling
from data to interpretation to action and last mile being behavioral change. So where I think
we are drowning at the moment is the volume of information, right? It is very, very easy to
gather an overwhelming amount of data with wearables. Back in the day, it was pretty painful
to painstakingly gather this stuff with your own spreadsheets and so on. Now it's trivial. It is
easy to amass an ocean of ones and zeros related to yourself with your aura ring, which I use,
or your whoop band or whatever it might be, plus add any number of other inputs. So much like a lot
of other things, it's easy to amass an ocean of ones and zeros related to yourself with your aura
ring, plus add any number of other inputs. So much like a lot of other inputs. So much like
books and presentations, we're not failing from too little information. We're failing from too
much information, I think. So there's the interpretation layer. And I do think your
inputs matter. So the metabolomics, proteomics, I think all of that, I think is incredibly
interesting. But ultimately what it comes down to, for instance, in the realm of Alzheimer's
disease, there are people who have these very fancy collections of very esoteric biomarkers.
And that's great. And you can watch how they trend. But how does it change the clinical
intervention? And the answer is
as it stands right now it doesn't okay fine maybe this is a case of harvest now decrypt later okay
so maybe we gather all this stuff on my relatives and it's too late for them but five years in the
future we have this data so we can do a retroactive analysis with fancy tools ai quantum computing
whatever i don't think we need quantum computing for that but to derive some type of directional
signal for people now who have better interventions okay fine but i think that's kind of a leap as it
stands right now so i'm looking for how something informs action and that's not always terribly
clear then how do you facilitate action this is the big one because for healthy normals who are
wearing any number of different tools or having various tests done they get back all this stuff
maybe
they're given an interpretation maybe it has to get pushed to their primary care physician
and in some cases it's going to spot something that is really nefarious or a trend line that
deserves intervention i'll give a simple example not to say that hemoglobin a1c is the end-all be
all i recognize this but it's a simple marker well in some ways not so simple but it's an easy
one that a lot of at least americans will recognize so hemoglobin a1c is described
by many doctors as your three month or so running average of glucose and it's used to
infer your insulin sensitivity and so on because your fasting insulin can swing all over the place
certainly your insulin can swing all over the place ultimately i do think an ogtt like most
people if they can afford it which they can should get an oral glucose tolerance test where you're
kind of taking blood and measuring things every 30 minutes for two hours talk to your doctor but
if you have hemoglobin a1c and you're looking at your trend line all right it's creeping up
hemoglobin a1c appears to be going up over three quarters and if you telescope that out uh-oh i'm
going to end up being a type 2 diabetic we should do something sooner rather than later what's the
advice now you could have a pharmacological intervention who knows what that is right
put someone on low-dose triseptide maybe somebody thinks that metformin is a good idea frequently it
isn't
whatever that might be but for a lot of folks the answer is going to be clean up your diet
and do more exercise of some type how do you get those fucking people to do that
especially when the pain isn't painful enough they're like i got plenty of time it's not that
bad i'm still in range even though trend line would say sooner or later you're going to be
out of range and if you wait and wait and wait you're going to have a much larger problem that
is lodged deeply into your physiology
that's going to be problematic the behavioral change piece i think is huge and that is currently
what's missing i am hoping to do a bunch with that with a company that i probably shouldn't name so i
won't get into it but i am hoping to do a lot on that side since that's effectively what i do
professionally is focus on behavioral change that's a very very long answer but hopefully
that's somewhat helpful sorry for uh again the accidental ted talk beware those ketones gets
y'all fired up all right you're going to be okay i'm going to be okay i'm going to be okay i'm going to
just question what was tim like before you took psychedelics what was the biggest shift
i'm sighing not because it's a bad question i'm sighing because i have to keep saying it's
important i talk more people out of psychedelics than i talk into psychedelics if your buddy
invites you to your first psychedelic experience which is some rent a shaman giving ayahuasca and
topanga canyon i would run the other direction i mean these are as my old friend who sadly passed
away iconic psychedelics i would run the other direction i mean these are as my old friend who
researcher in the field roland griffiths would say you're using nuclear power it is very very
powerful you have to be very careful and i would treat these compounds as if you're considering
having spinal surgery or neurosurgery you do a lot of homework and you'd measure twice and cut once
with that disclaimer said i mean before psychedelics i there were gigantic psychological
and emotional icebergs causing incredible problems
in my life that i was wholly unaware of i was also completely unaware of how 17 different
problems all related to one or two core problems so there's a value in diagnosing or seeing the
unseen and i'm not talking about mechanical elves in this case that's a separate q a i'm talking
about simply seeing your life and behavior as an objective third party would see it
as if they had 2020 vision right that's incredibly difficult to do in sort of ordinary consensus
reality it's very very hard to do and in that experience it is very common that you're able
to take off the glasses you didn't realize you were wearing and inspect the lens see how it's
affecting everything else so that's part one part two aside from the diagnostic capability
is the i don't want to say curative but the therapeutic potential of contending with issues
like ptsd contending with issues like depression it is not a panacea on any level it's contraindicated
for lots of people who might have a family history of schizophrenia or borderline personality
disorder the most interesting tool for those types of conditions
that i've found is metabolic psychiatry the ketogenic diet effectively but it doesn't
really need to be 100 ketogenic but look at what sami incanin is doing look at what chris palmer is
doing dom dagostino has also commented on this at great length but i know this is a real pregnant
pause i was able to put down a lot of very very heavy exhausting boulders that i didn't even
realize i was carrying that's the way i would put it life is lighter also you know let's say you're
a lot of people are i didn't even learn to swim until i was in my 30s really i was definitely
afraid of drowning couldn't swim even two laps in a limbic size swimming pool not even one lap
half a lap i guess we're considering back and forth a lap and if you look at how that's best
overcome that fear this is going somewhere i promise you might find a great method like
total immersion swimming created by a guy named terry lachlan who became a friend i did his last
interview before he passed away
and where they start is not trying to do laps it's not swimming in deep water it's simply
submerging your head as if you were trying to teach an infant how to do survival swimming
also something very interesting that i'm not going to get into so simply dunking your head
dunking your head dunking your head and then you might start with studying gliding positions
how do you use the least energy to go the furthest distance go to the shallow end
and you would practice getting into say fuselage right fuselage left position no attention to
breathing okay you're kicking off the wall going as far as you can and then you're standing up
and then you're rinsing and repeating and before long literally within a handful of months i swam
more than a mile open water in the ocean i don't think that's actually an outlier if you practice
this technique and this type of repeated exposure psychedelics are a very very unusual form of
repeated exposure and i think it's a very very unusual form of repeated exposure and i think it's
a very very unusual form of repeated exposure and there is such a thing as doing too much
psychedelics i know people who have lost the plot you can really slip and get lost you should take
that seriously spend more time in consensus reality than you do in psychedelic land
or you can end up in a semi-permanent state of alice in wonderland it's not a good idea but
what i mean is if over time and that could only be once or twice maybe three times but what you
see for instance in some terminal cancer patients
is fear extinction of death that is pretty interesting they lose their fear of death why
because they already experienced what they subjectively felt to be ego death that's a scary
way to put it that's how it's phrased often eco dissolution what does it mean to experience
consciousness without any sense of self without any name without any perception of time it's
pretty strange is what it is but it also ends up being
for a lot of people very peaceful even if it's type two piece like type two fun hard in the
moment then afterwards you're like wow i feel really at peace i have fear of deterioration
and things like alzheimer's disease but like death not really so afraid of it and that's been
true for a long time now i credit that almost exclusively to psychedelics and it's hard to
put a value on that it's such a bizarre thing to even posit but writ large it does seem to
remove a base layer of anxiety that comes with the awareness that you are going to die right that's
a big one so i didn't expect to give such a fucking long answer but i guess that's the theme
of the evening all right just to reiterate what i said about building this is daniel h number three
commenter meaning like number three ranked with the crown claude code is mind-bendingly good it
can take you from zero to hero and it can take you from zero to hero and it can take you from zero to
hero or at least reasonably competent yeah it is really remarkable what you can build with these
things all right
Here's a question, once again, with the caveat that I'm not a medical professional to talk to
your doctor. This is actually a question, a variance of this question I get a lot. Val had
a question on natural statins for those healthy young fellows with genetically high cholesterol
slash heart disease. What do you think? This returns to a very old topic, which I unpacked
at length in the 4-Hour Body. So there is that, but I'll give you the TLDR. And that is all natural
versus synthetic. All natural does not automatically mean safe. And I do take certain
supplements. I do take certain herbs. The challenge with that is there's very little regulation
and very little standardizing. So for instance, if you look at examine.com or other places that
have taken 10 off-the-shelf melatonin supplements and had them analyzed,
just say they're all supposed to be three milligrams. By the way, you can't even buy
melatonin in some countries for pretty good reasons. But forget that part. You have 10 of
them analyzed. They all say three milligrams of melatonin. Some have precisely fuck all of
zero. They contain no melatonin. And some contain up to 20 milligrams of melatonin. That is a problem.
If you are making the assumption for the moment that a supplement does something, having that
ability on dosing is a bad thing. It is a bad thing. Also, there are many things that are all
natural, hemlock, arsenic, that are incredibly dangerous. So if you take ephedrine hydrochloride
and then you're like, well, I'm going to use Mahuang instead, this Chinese, you can still
get yourself into a lot of trouble. There are cases where it's interesting to consider what
the mix of various alkaloids and so on,
does versus an isolation. So you might look at, in the case of psychedelics,
iboga versus ibogaine hydrochloride. It's a worthwhile question. I would just say it needs
to be studied with rigorous scientific controls for us to feel confident that we are not fooling
ourselves. And you can do that. So in the case of, say, ayahuasca, how does ayahuasca differ
or how might it differ in its effects versus vaporized NNDMT?
Since ayahuasca contains NNDMT, and the way it is commonly explained is ayahuasca contains
this NNDMT that's found in the leaf of this plant called the chacruna, and it is not bioavailable
when you take it orally, therefore you consume. And the ancients figured out, as they did,
you macerate, smash, and combine it with this vine, which contains monoamine oxidase
inhibitors, and voila, suddenly you absorb it.
And at the end of the show, the molecule that did the most action is NNDMT.
Well, in a case like that, it turns out that the beta-carbolines in the vine itself,
in a harmine and harmaline and so on, have some really interesting effects of their own.
But to come to your specific question on cholesterol, I don't know if you're talking about
red rice extract or other things, but when it comes to mortality,
in my family, for instance, which of the four horsemen of death is going to get you?
Is it neurodegenerative? Is it cardiovascular? Is it something else? And I think Peter Tia does a
good job of describing these in his book, Outlive. But in my family, all the males die of heart
attacks. That's basically it. Everyone dies of heart problems. So if I were to use something
that were an herbal supplement, number one, I would need to have it tested, and I would need
multiple batches over a period of several months. So I'd buy one, I'd have it tested. Maybe I wait,
maybe I take it, maybe I wait. Another month later, I buy a bottle. Hopefully it's a different
lot number. I have that tested. Do the results come back the same? This is an important question.
Now, I also said, though, these organic broad-spectrum products, if they haven't been
sufficiently studied, some of them have been, can have unintended off-target effects. So
if I'm trying to avoid death,
and I'm no spring chicken, I'm 49, I would prefer to take what has the longest history of supportive
data with the lowest downside risk. And if you do more sophisticated lipid analysis and so on,
look at your genetics. In my case, you can figure out I'm a cholesterol hyperabsorber. That's not
true for everyone. But if a doctor of mine says, we want to put you on these four medications,
I could look at those medications. You really have to be your own advocate in medicine. And I could
say, well, which of these medications have been on the market the longest and been studied most
rigorously? Which is the most innocuous of the whole lot? And in this particular case, it ended
up being something called ezetimibe, which has been extensively studied. Brand name, Zetia.
And the question I posed was, well, okay, if the goal moving forward is to be under the curve,
it's sort of like total surface area under the curve of having these values.
At certain target levels or below certain levels, there's no immediate rush. I'm not getting
triple bypass, quadruple bypass surgery. Could I, is it okay with you if I start with this most
innocuous, best studied drug to see if I am a hyper responder? Answer yes. Try to guess what,
I'm hyper responder. I don't need to take the other three. So this is how I approach it.
But I do like the specificity, repeatability, consistency,
of certain drugs over their all natural alternatives, just because there are so many
unknowns in the supplement world or all natural world. By the way, that's also why I think broadly
speaking, since a lot of people are interested in psychedelics, that something like LSD or a
or an MDMA is more interesting from a mainstream healthcare perspective. If we're talking about
mental health, because 50 micrograms is 50 micrograms is 50 micrograms. If you have your
synthesis dialed, whereas with ayahuasca, if it's sort of the shamanic eyeball dose,
there are too many variables. There's cook time, there's concentration, there's leaves,
there's add mixtures. It's like a cup of ayahuasca is not a cup of ayahuasca is not a cup of ayahuasca,
even if you're doing your best. Now, there are some interesting approaches. Hamilton Morris and I
farm ayahuasca and basically trying to replicate the combination using drugs. I've never messed
around with that personally, but I have seen more people get very destabilized from ayahuasca
and underestimating LSD, but that's a separate problem because it's not the cool
kid on the block right now. It's old. So people underestimate just how potent it is.
But in the case of ayahuasca is because people have one or two cups that are really light in
consistency. And then they're like, I'm an ayahuasca pro and they go to South America and
they have something that has consistency of honey and they get destroyed. It's that inconsistency
that I don't like. So long answer to a short question as per usual this evening,
Tim's the supplements company, worst nightmare. Yeah. Most of the time.
It's also a reason why it was so expensive to build my first company because I actually did
all the due diligence and standardizing. It's very, it's much more expensive to try to put in
operating procedures than to not. So most people choose the not. How are my teeth so white? That's
a good one, Jennifer. Okay. I have an interesting question since you spoke of dental health. How
are your teeth so white? They're not veneers. I can think of something about Mary or some of
these actors you see in Hollywood and you're like, God, that looks unnatural. Plus they look a little
too big. It's just, it's a spooky look. Never say never. Who knows? Maybe they'll get yellow
enough at some point that I'll, I'll choose to bite the bullet. But I attribute
this to the xylitol gum and xylitol mouthwashes. I don't really have any other explanation
because I always brush my teeth. Great. Okay. Upgraded to a Sonicare a few years ago,
just because I've had receding gums since I was a little kid. I had surgery when I was a kid,
actually, where they cut out a piece of your palate and grafted onto your gums. Very painful.
Don't want to have that again. And I tend to be a vigorous, vigorous, I got through a little Sean
toothbrusher. So the Sonicare just does more delicate job, but that's been true for years.
And sure. I added in a water pick of sorts, although I use a different brand.
The only explanation that I have, I don't use the whitening strips or anything like that.
The only variable that is new is the xylitol gum and mouthwash containing xylitol, which I use
probably twice a day. And actually I have one I can show you. This was recommended by Tommy Wood.
It's called Bite, B-I-T-E, mouthwash bits, 124 bits. This will last you forever.
And you can hear they are these tiny little, they're not tablets. They look like tiny
candies. And these are great for travel, but I use them at home as well.
You basically crunch it up, chew it, break it up into powder in your mouth.
And then you take a tiny swig of water and voila, you have mouthwash that includes xylitol.
swish it around for a minute, spit it out. That's it.
I have it here. So after a meal, I'll rinse my mouth, throw one of these in and then spit it
out. It doesn't take any time at all. That's habit stacking also. Hat tip to all the oldies who
set the path. But that's the only thing I can think of. So thanks for the question. And that
makes me really happy. I haven't had anyone say that to me. So I'm thrilled. No white teeth
filters on this video. I'll hit a couple of fast ones. Stephanie. Hi, Tim. You're the master of
efficiency and maximizing impact. Thanks for all I've learned over the years. My question is,
what is one of your favorite things to keep doing inefficiently? Long meals, long coffees. I had a
two-hour coffee chat today with someone I can't mention, but nothing for the podcast. Just
bullshitting, exploring the world via conversation with somebody and reading fiction. Certainly.
I'm also watching Mobland and stuff. I mean, let's not kid ourselves. I do like the visual
storytelling. I think a new episode is coming out today. So I am excited. And then next question,
from Mike, any thoughts on tech neck, tech neck, pointing at my neck, prevention, better posture
tricks, and slowing the inevitable for people who sit at computers a lot. Yes. I actually have some
very simple recommendations for this. One is meditate twice a day. I, after meditating,
doing TM in this case, 20 minutes, twice a day, sitting in a straight stacked position,
not hyperextended, not slouching. After about four weeks of doing that, especially after a few months
of doing that, started getting compliments on my posture out of nowhere. People would say,
you have the best posture. You walk like a dancer. And I'd say, what? And it took me a while to figure
out that the meditation was the cause. I was strengthening or conditioning two things,
motor patterning for holding myself in this balanced stacked position. I was also
training slow twitch muscle fibers, these postural muscles,
that fall apart if you're just collapsing. They don't fall apart, but they certainly don't do
their job if they're chronically tight. Also getting massage once a week. I've done that
ever since I was poor. AF. Look, you can find a Chinese massage place and get a massage for 10,
20 bucks. I don't want to hear the excuses. You can also use self-massage tools. I've got
Theracanes and so on all over the house. Theragun, you name it, all the Theras.
Work on your pectoralis minor and make sure your chest is not overly tight. That will also help.
And don't mess around with the chairs. Get a good chair and then do more work on laptop than your
phone. And this laptop right now is elevated. Why is it elevated? Because I want to be looking
straight. I don't want to be craning my neck. This is what I was going to use, but it was going
to be too high. This is a laptop stand. I'm not sure if you can see it. It says Roost.
This is my favorite laptop stand. It's very easy to throw in a backpack or a tote bag or
whatever. It's incredibly easy to travel with. So those are a few tips, but honestly, meditate twice
a day for 20 minutes and you will build the posture. It is a habit and it's also muscular.
Okay, Andres, minimum effective dose for becoming more flexible. Look at the gymnastic strength
training I mentioned, GSD with Coach Chris Sommer. Long story short, it is developing
strength in your end ranges, not a lot of passive stretching. So working active flexibility. So I'll
give you an example of what that means. If you were to sit on the floor with your legs extended out
in front of you together, toes pointed, all right, so that's a pike position. And then keeping your
back entirely flat, put your fingers on the floor. You can be on your fingertips, walk them forward,
and then try to pulse your legs up, keeping them completely straight, quads contracted. They're
pike pulses. Try to do 20 of those. They are very hard. If you do that, plus some of the ab exercises
from the happy body, for instance, laying on your back with your legs straight up in the air,
and then reaching up again with your legs locked. In this case, toes pulled back. You're strengthening
in the end range and do all sorts of things like the Golgi tendon reflex and all sorts of different
types of inhibition. Your body then learns, I am strong enough to not get injured in a slightly
broader range of motion, and you will get more flexible. So developing strength in the end
ranges. Be very careful with your shoulders. Don't push it on the shoulders. For me, that is what has
given me the best ROI on flexibility and mobility and active flexibility in the least time. This is
from Handy, Hyundai. When you were a kid, what was the one mundane thing you couldn't wait to
grow up and do? Not buying a car or something like that, but something small like going out
alone in the evening that felt like the ultimate adult privilege. All right. When I was a busboy
working for table scraps, I worked at a lot of restaurants, started when I was 14,
cleaning an ice cream shop. I got fired from that one. Different story. But I remember being a busboy
at this one restaurant. This is out on Long Island. And all these fancy people from Manhattan would
come out on the weekends and visit their fifth homes or whatever. And I had the shitty shift.
It was like the late afternoon shift because the best shifts went to the people who'd been there
longer, obviously. But there was one experience that salvaged it for me. One in particular. There
the iconic musician would come in a few times a week, sit down. He would have a cup of coffee,
read the newspaper, and he tipped $20. And to me, that blew my fucking mind that Billy Joel
was rich enough to have a coffee and then tip me $20. It just blew my mind. I mean,
I was like, one day, oh my God, imagine if one day I could walk,
and have a coffee, and tip some kid $20. That was just the ultimate. What a fantasy.
So that's what comes to mind. That was the ultimate for me. It's fun to do when you have
the chance. From Tonya in Maine or Tanya, what are your favorite one, two, or three birds and why?
Look, I don't have a lot of time to get into it because I want to run. Red-tailed hawk,
for a lot of reasons, you can look it up. But also I had my first
training in falconry with a red-tailed hawk. Very common in North America. Very good beginner
bird for falconry. It will be very forgivable of certain types of mistakes, but it's not so good.
There are certain birds that will cover your inadequacies so effectively that you don't
improve as a falconer. So red-tailed hawk, hummingbird, many types of hummingbirds.
And then you guys can look it up. The superb bird of paradise. What a name. Man,
wouldn't you like that on your LinkedIn? Some of you will recognize,
this bird visually, but not by name. If you've seen planet earth and it has this spectacular
electric blue hood, basically that it can create the male for this fancy dance that it does after
creating small clearing. So that's the superb bird of paradise. This is from Andy. How do you decide
when to keep investing in a friendship versus accepting that it's become one-sided on some
level? This is not true all the time, but if you're asking that question, maybe you have your answer,
but I would not come to that conclusion until you have improved.
Your ability to communicate as much as possible. Crucial conversations. I mentioned it
twice already. The 15 commitments of conscious leadership also very much related to this topic.
And even though it has been used within the world of fast-growing tech, for instance, Asana,
it was Asana. Many tech startups have all of their managers, employees read these books.
I'm pretty sure it's Asana and Dustin Moskowitz. It applies to relationships and any relationships.
And a lot of it's based on the work of Gay and Katie Hendricks. If you want to look up,
for instance, Conscious Loving and other books that they have penned. But the 15 commitments
of conscious leadership kind of gets to the point quickly and offers you tools that you can use.
And then the last question from Matt E. Are you at peace? I would say more than ever. More than
ever before, I'm feeling pretty good. And that's not a function of finances. I can say that
definitively because I've been okay with it. I've been okay with it. I've been
okay. Unworried financially for a very long time. Thankfully, I'm very, I've had a lot of good luck
born in the right place, you know, in the U S land of opportunity, et cetera, et cetera, et cetera.
But that's not enough. A lot of the tools we've already talked about does take, in my case,
took some heavy lifting, but I would say that I have never been more at peace. I feel great.
Very, very excited about the future. And I know that there are going to be some big,
big challenges individually and societally. I mean, I have,
very close relatives who are in terrible shape. I just supported an uncle through hospice. He's
no longer with us. That's very recent. Shit happens, but I have never been more at peace
and things can change, but it's been pretty stable for a number of years now. So I'm very
grateful for that. I don't take it for granted. And I wish the same and more for all of you.
Thank you for tuning in guys. I'm going to get to the gym at long last. And it's always fun to do
these. If you haven't chimed in on format ideas, let me know on Twitter. I will call it Twitter,
but on X at T Ferris hashtag format. And I'm sure we'll have lots of show notes for this episode.
So for people who are listening and watching this by the time you hear or watch this,
you can go to Tim dot blog slash podcast, a guest search for Q and a and find the latest one.
And I will stop there for now. Thank you guys so much for tuning
in, whether you did it live or you're doing it asynchronously.
all the cool kids are doing and until next time two things one if you're suffering you're not
alone there are tools that work so check out the show notes and look at some of the things
that we covered there are things that actually work pretty consistently and second be just a
bit kinder than is necessary to others sure of course but also to yourself learn to work on that
inner monologue and to do that you have to develop awareness i had very little of it for a long time
speaking of awareness check it out awareness by anthony de mello the book i've gifted more than
100 times probably at this point and that i have read probably 15 to 20 times myself and with that
goodbye and good night hey guys this is tim again just one more thing before you take off and that
is five bullet friday would you enjoy getting a short email from me every friday that provides a
little fun before the weekend between one and a half and two million people subscribe to my free
newsletter
my super short newsletter called five bullet friday easy to sign up easy to cancel it is
basically a half page that i send out every friday to share the coolest things i've found
or discovered or have started exploring over that week it's kind of like my diary of cool things it
often includes articles i'm reading books i'm reading albums perhaps gadgets gizmos all sorts
of tech tricks and so on that get sent to me by my friends including a lot of podcast guests and
these strange
esoteric things end up in my field and then i test them and then i share them with you so if that
sounds fun again it's very short a little tiny bite of goodness before you head off for the
weekend something to think about if you'd like to try it out just go to tim.blog slash friday type
that into your browser tim.blog slash friday drop in your email and you'll get the very next one
thanks for listening as some of you might recall i launched my own limited edition coffee a few years
back it was delicious it was a blast but that's a story for another time here's why i'm bringing it
up i needed and wanted an online store that would be beautiful fast and reliable plus a checkout
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i've known the team since 2009 when they had something like 10 employees and i was using it
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Thank you.
Podcast Summary
Key Points:
Tim Ferriss takes a proactive, multi-pronged approach to Alzheimer’s risk, combining lifestyle interventions like sauna, interval training, and supplements such as Urolithin A and lithium orotate.
He emphasizes that early prevention is critical, as neurodegenerative processes begin in the 30s–40s, and current medical treatments remain primitive and inconsistent.
Behavioral change is central to long-term health, and he highlights tools like fear setting and cognitive behavioral therapy (CBT) to break stubborn patterns and build resilience.
He advocates for "upside time" and "downside time" in daily routines—deliberately seeking hope and risks—to counteract societal negativity and foster mental clarity.
Psychedelics are viewed as powerful for self-diagnosis and emotional insight, though used cautiously due to risks and lack of standardization; he emphasizes their anti-inflammatory effects at microdoses.
He cautions against unregulated supplements, stressing the need for testing, consistency, and clinical evidence, especially in high-risk health areas like cholesterol.
He promotes practical, evidence-based self-experimentation—like building AI projects or practicing skills—to stay current and engaged with emerging technologies.
Quantified self 2.0 must move beyond data collection to meaningful interpretation and action, with behavioral change being the most critical missing piece in current self-tracking.
Summary:
Tim Ferriss outlines a comprehensive, science-informed strategy for managing his genetic risk of Alzheimer’s, emphasizing early prevention and lifestyle interventions such as regular saunas, interval training, and targeted supplements. He critiques current medical approaches as outdated and notes that neurodegenerative processes begin decades before diagnosis. Behavioral change remains central, with tools like fear setting, cognitive behavioral therapy, and habit stacking to help break entrenched patterns.
To maintain mental resilience amid a culture of pessimism, Ferriss advocates for structured "upside time" and "downside time" routines—deliberately seeking hope and risk—to counteract negativity. He cautiously supports psychedelics as powerful diagnostic and therapeutic tools, especially for uncovering hidden emotional patterns, while warning of their risks and variability. He strongly cautions against unregulated supplements, stressing the need for standardized testing and proven efficacy, especially in areas like cholesterol management.
Ferriss promotes hands-on learning with AI and self-building projects as effective ways to stay current. He also reflects on the limitations of self-tracking, arguing that data volume overwhelms insight—true value lies in actionable interpretation. Ultimately, he champions a holistic, proactive lifestyle where mental resilience, behavioral change, and evidence-based decision-making converge to build long-term health and adaptability.
FAQs
Tim practices regular sauna use (20 minutes, 170–180°F), does interval training like Norwegian 4x4, takes supplements like Urolithin A for mitochondrial health, uses five milligrams of lithium orotate, maintains good dental health with xylitol-based products, and engages in consistent physical activity. He emphasizes that prevention is key, noting that Alzheimer’s risk starts as early as the 30s or 40s.
Tim finds psychedelics helpful for gaining objective insight into his life patterns and identifying hidden emotional issues. He views them as powerful tools for self-diagnosis and therapeutic exploration, but warns against overuse and emphasizes caution, especially for those with a history of mental health conditions. He also notes that their effects are often linked to reducing chronic neuroinflammation.
He sets aside 'upside time' in his calendar to actively seek positive, hopeful stories and opportunities, and 'downside time' to assess risks. He avoids social media to reduce exposure to negativity and reads books like 'Hard Times' to witness human resilience. He believes optimism is both a mindset and a skill built through action and learning.
He prefers prescription drugs with long-standing, rigorous study and low risk, like ezetimibe (Zetia), over unregulated supplements. He warns that natural doesn’t always mean safe, citing inconsistent dosing and lack of standardization in supplements. He stresses the importance of testing products and choosing the most studied, reliable options.
Behavioral change is central to his approach. He emphasizes tools like fear setting, which involves writing about the cost of inaction over time, to make change more compelling. He also promotes habit stacking, such as using xylitol gum after meals, to build sustainable routines that support long-term health.
He believes self-tracking is valuable but warns against information overload. The key is interpreting data to guide action, not just collecting data. He notes that metabolomics is promising but currently lacks clear clinical interventions, and true value comes when data leads to measurable behavioral or health changes.
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